Lactate modulation of immune responses in inflammatory versus tumour microenvironments

The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironme...

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Veröffentlicht in:	Nature reviews. Immunology 2021-03, Vol.21 (3), p.151-161
Hauptverfasser:	Certo, Michelangelo, Tsai, Chin-Hsien, Pucino, Valentina, Ho, Ping-Chih, Mauro, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2161 631/250/256/2515 Bioavailability Biological Availability Biomedical and Life Sciences Biomedicine Carrier Proteins - metabolism Comparative analysis Cytotoxicity Development and progression Health aspects Humans Hypoxia Immune response Immunology Immunomodulation Inflammation Inflammation - immunology Inflammatory diseases L-Lactate Dehydrogenase - metabolism Lactates Lactic acid Lactic Acid - metabolism Membrane Proteins - metabolism Metabolism Metabolites Microenvironments Neoplasms - immunology Neoplasms - pathology Nutrients Physiological aspects Review Article Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism Tissues Tumor microenvironment Tumor Microenvironment - immunology Tumors
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