Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery
The aim of the present study was to prepare a resveratrol-loaded microsponge-based dry powder inhaler (RES-MS-DPI) using the quasi-emulsion solvent diffusion method and to explore its suitability for pulmonary delivery. The prepared microsponges were evaluated for physicochemical properties. Additio...
Gespeichert in:
| Veröffentlicht in: | BioNanoScience 2021-03, Vol.11 (1), p.32-43 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 43 |
|---|---|
| container_issue | 1 |
| container_start_page | 32 |
| container_title | BioNanoScience |
| container_volume | 11 |
| creator | Mali, Ashwin J. Rokade, Anamika Kamble, Ravindra Pawar, Atmaram Bothiraja, C. |
| description | The aim of the present study was to prepare a resveratrol-loaded microsponge-based dry powder inhaler (RES-MS-DPI) using the quasi-emulsion solvent diffusion method and to explore its suitability for pulmonary delivery. The prepared microsponges were evaluated for physicochemical properties. Additionally, an in vitro lung deposition study was performed using an Andersen cascade impactor (ACI), while in vivo performance was studied by intratracheal administration. The optimized porous and spherical RES-MS showed particle size, surface charge, entrapment efficiency, mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of 2.499 ± 0.56 μm, −25.34 mV, 89.45 ± 0.23%, 2.13 ± 0.21 μm and 48.54 ± 0.25%, respectively, with controlled release. Further, in vitro and in vivo studies of RES-MS showed a twofold improvement in the FPF, and 4.4-, 14.12- and 1.94-fold improvement in the area under the curve (AUC), mean residence time (MRT) and C
max
. The RES-MS exhibited higher aerosolization and lung deposition.
Graphical abstract |
| doi_str_mv | 10.1007/s12668-020-00800-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2495449199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2495449199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-a538a66d633a4ddcb70f3c9d94371c3cecd6288c8310d0af33e37572a4686e8c3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRSMEElXpD7CyxNpgx6ljsystj0rhIR5ry7UnIVWIi522yt_jUgQ7ZjMz0r13NCdJTik5p4TkF4GmnAtMUoIJEYTg_CAZpFRSTHkmD39nRo6TUQhLEisnnAk2SLbPEDbgdeddgwunLVh0Xxvvwsq1FSAdkEYPbgMNuqqdhcprqxcNoKn2vgaPSufRzPfoyW1tXOftu27AX6IJeoAteuliNFQ9qltUrNsKzaCp473-JDkqdRNg9NOHydvN9ev0DhePt_PppMCGUdlhPWZCc245Yzqz1ixyUjIjrcxYTg0zYCxPhTCCUWKJLhkDlo_zVGdccBCGDZOzfe7Ku881hE4t3dq38aRKMznOMkmljKp0r9o9HjyUauXrD-17RYnaMVZ7xioyVt-MVR5NbG8KURxZ-b_of1xfRSt-rQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2495449199</pqid></control><display><type>article</type><title>Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery</title><source>SpringerLink Journals - AutoHoldings</source><creator>Mali, Ashwin J. ; Rokade, Anamika ; Kamble, Ravindra ; Pawar, Atmaram ; Bothiraja, C.</creator><creatorcontrib>Mali, Ashwin J. ; Rokade, Anamika ; Kamble, Ravindra ; Pawar, Atmaram ; Bothiraja, C.</creatorcontrib><description>The aim of the present study was to prepare a resveratrol-loaded microsponge-based dry powder inhaler (RES-MS-DPI) using the quasi-emulsion solvent diffusion method and to explore its suitability for pulmonary delivery. The prepared microsponges were evaluated for physicochemical properties. Additionally, an in vitro lung deposition study was performed using an Andersen cascade impactor (ACI), while in vivo performance was studied by intratracheal administration. The optimized porous and spherical RES-MS showed particle size, surface charge, entrapment efficiency, mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of 2.499 ± 0.56 μm, −25.34 mV, 89.45 ± 0.23%, 2.13 ± 0.21 μm and 48.54 ± 0.25%, respectively, with controlled release. Further, in vitro and in vivo studies of RES-MS showed a twofold improvement in the FPF, and 4.4-, 14.12- and 1.94-fold improvement in the area under the curve (AUC), mean residence time (MRT) and C
max
. The RES-MS exhibited higher aerosolization and lung deposition.
Graphical abstract</description><identifier>ISSN: 2191-1630</identifier><identifier>EISSN: 2191-1649</identifier><identifier>DOI: 10.1007/s12668-020-00800-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biodegradability ; Biological and Medical Physics ; Biomaterials ; Biophysics ; Charge efficiency ; Circuits and Systems ; Controlled release ; Deposition ; Engineering ; Entrapment ; In vivo methods and tests ; Inhalers ; Lungs ; Nanotechnology ; Physicochemical properties ; Resveratrol ; Surface charge ; Trachea</subject><ispartof>BioNanoScience, 2021-03, Vol.11 (1), p.32-43</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-a538a66d633a4ddcb70f3c9d94371c3cecd6288c8310d0af33e37572a4686e8c3</citedby><cites>FETCH-LOGICAL-c319t-a538a66d633a4ddcb70f3c9d94371c3cecd6288c8310d0af33e37572a4686e8c3</cites><orcidid>0000-0002-0391-1606</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12668-020-00800-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12668-020-00800-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Mali, Ashwin J.</creatorcontrib><creatorcontrib>Rokade, Anamika</creatorcontrib><creatorcontrib>Kamble, Ravindra</creatorcontrib><creatorcontrib>Pawar, Atmaram</creatorcontrib><creatorcontrib>Bothiraja, C.</creatorcontrib><title>Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery</title><title>BioNanoScience</title><addtitle>BioNanoSci</addtitle><description>The aim of the present study was to prepare a resveratrol-loaded microsponge-based dry powder inhaler (RES-MS-DPI) using the quasi-emulsion solvent diffusion method and to explore its suitability for pulmonary delivery. The prepared microsponges were evaluated for physicochemical properties. Additionally, an in vitro lung deposition study was performed using an Andersen cascade impactor (ACI), while in vivo performance was studied by intratracheal administration. The optimized porous and spherical RES-MS showed particle size, surface charge, entrapment efficiency, mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of 2.499 ± 0.56 μm, −25.34 mV, 89.45 ± 0.23%, 2.13 ± 0.21 μm and 48.54 ± 0.25%, respectively, with controlled release. Further, in vitro and in vivo studies of RES-MS showed a twofold improvement in the FPF, and 4.4-, 14.12- and 1.94-fold improvement in the area under the curve (AUC), mean residence time (MRT) and C
max
. The RES-MS exhibited higher aerosolization and lung deposition.
Graphical abstract</description><subject>Biodegradability</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biophysics</subject><subject>Charge efficiency</subject><subject>Circuits and Systems</subject><subject>Controlled release</subject><subject>Deposition</subject><subject>Engineering</subject><subject>Entrapment</subject><subject>In vivo methods and tests</subject><subject>Inhalers</subject><subject>Lungs</subject><subject>Nanotechnology</subject><subject>Physicochemical properties</subject><subject>Resveratrol</subject><subject>Surface charge</subject><subject>Trachea</subject><issn>2191-1630</issn><issn>2191-1649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRSMEElXpD7CyxNpgx6ljsystj0rhIR5ry7UnIVWIi522yt_jUgQ7ZjMz0r13NCdJTik5p4TkF4GmnAtMUoIJEYTg_CAZpFRSTHkmD39nRo6TUQhLEisnnAk2SLbPEDbgdeddgwunLVh0Xxvvwsq1FSAdkEYPbgMNuqqdhcprqxcNoKn2vgaPSufRzPfoyW1tXOftu27AX6IJeoAteuliNFQ9qltUrNsKzaCp473-JDkqdRNg9NOHydvN9ev0DhePt_PppMCGUdlhPWZCc245Yzqz1ixyUjIjrcxYTg0zYCxPhTCCUWKJLhkDlo_zVGdccBCGDZOzfe7Ku881hE4t3dq38aRKMznOMkmljKp0r9o9HjyUauXrD-17RYnaMVZ7xioyVt-MVR5NbG8KURxZ-b_of1xfRSt-rQ</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Mali, Ashwin J.</creator><creator>Rokade, Anamika</creator><creator>Kamble, Ravindra</creator><creator>Pawar, Atmaram</creator><creator>Bothiraja, C.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0391-1606</orcidid></search><sort><creationdate>20210301</creationdate><title>Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery</title><author>Mali, Ashwin J. ; Rokade, Anamika ; Kamble, Ravindra ; Pawar, Atmaram ; Bothiraja, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-a538a66d633a4ddcb70f3c9d94371c3cecd6288c8310d0af33e37572a4686e8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biodegradability</topic><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biophysics</topic><topic>Charge efficiency</topic><topic>Circuits and Systems</topic><topic>Controlled release</topic><topic>Deposition</topic><topic>Engineering</topic><topic>Entrapment</topic><topic>In vivo methods and tests</topic><topic>Inhalers</topic><topic>Lungs</topic><topic>Nanotechnology</topic><topic>Physicochemical properties</topic><topic>Resveratrol</topic><topic>Surface charge</topic><topic>Trachea</topic><toplevel>online_resources</toplevel><creatorcontrib>Mali, Ashwin J.</creatorcontrib><creatorcontrib>Rokade, Anamika</creatorcontrib><creatorcontrib>Kamble, Ravindra</creatorcontrib><creatorcontrib>Pawar, Atmaram</creatorcontrib><creatorcontrib>Bothiraja, C.</creatorcontrib><collection>CrossRef</collection><jtitle>BioNanoScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mali, Ashwin J.</au><au>Rokade, Anamika</au><au>Kamble, Ravindra</au><au>Pawar, Atmaram</au><au>Bothiraja, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery</atitle><jtitle>BioNanoScience</jtitle><stitle>BioNanoSci</stitle><date>2021-03-01</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>32</spage><epage>43</epage><pages>32-43</pages><issn>2191-1630</issn><eissn>2191-1649</eissn><abstract>The aim of the present study was to prepare a resveratrol-loaded microsponge-based dry powder inhaler (RES-MS-DPI) using the quasi-emulsion solvent diffusion method and to explore its suitability for pulmonary delivery. The prepared microsponges were evaluated for physicochemical properties. Additionally, an in vitro lung deposition study was performed using an Andersen cascade impactor (ACI), while in vivo performance was studied by intratracheal administration. The optimized porous and spherical RES-MS showed particle size, surface charge, entrapment efficiency, mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) of 2.499 ± 0.56 μm, −25.34 mV, 89.45 ± 0.23%, 2.13 ± 0.21 μm and 48.54 ± 0.25%, respectively, with controlled release. Further, in vitro and in vivo studies of RES-MS showed a twofold improvement in the FPF, and 4.4-, 14.12- and 1.94-fold improvement in the area under the curve (AUC), mean residence time (MRT) and C
max
. The RES-MS exhibited higher aerosolization and lung deposition.
Graphical abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12668-020-00800-7</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0391-1606</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2191-1630 |
| ispartof | BioNanoScience, 2021-03, Vol.11 (1), p.32-43 |
| issn | 2191-1630 2191-1649 |
| language | eng |
| recordid | cdi_proquest_journals_2495449199 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biodegradability Biological and Medical Physics Biomaterials Biophysics Charge efficiency Circuits and Systems Controlled release Deposition Engineering Entrapment In vivo methods and tests Inhalers Lungs Nanotechnology Physicochemical properties Resveratrol Surface charge Trachea |
| title | Resveratrol-Loaded Microsponge as a Novel Biodegradable Carrier for Dry Powder Inhaler: A New Strategy in Lung Delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T18%3A01%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resveratrol-Loaded%20Microsponge%20as%20a%20Novel%20Biodegradable%20Carrier%20for%20Dry%20Powder%20Inhaler:%20A%20New%20Strategy%20in%20Lung%20Delivery&rft.jtitle=BioNanoScience&rft.au=Mali,%20Ashwin%20J.&rft.date=2021-03-01&rft.volume=11&rft.issue=1&rft.spage=32&rft.epage=43&rft.pages=32-43&rft.issn=2191-1630&rft.eissn=2191-1649&rft_id=info:doi/10.1007/s12668-020-00800-7&rft_dat=%3Cproquest_cross%3E2495449199%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2495449199&rft_id=info:pmid/&rfr_iscdi=true |