Parallel genome-wide RNAi screens identify lymphocyte-specific protein tyrosine kinase (LCK) as a targetable vulnerability of cell proliferation and chemoresistance in nasopharyngeal carcinoma

Despite recent in advances in the management of nasopharyngeal carcinoma (NPC), development of targeted therapy remains challenging particularly in patients with recurrent or metastatic disease. To search for clinically relevant targets for the treatment of NPC, we carried out parallel genome-wide f...

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Veröffentlicht in:	Cancer letters 2021-04, Vol.504, p.81-90
Hauptverfasser:	Liew, Kitson, Yu, Gibson Qi Sheng, Wei Pua, Lesley Jia, Wong, Li Zhe, Tham, Shiau Ying, Hii, Ling-Wei, Lim, Wei-Meng, OuYong, Brian Ming, Looi, Chin King, Mai, Chun-Wai, Fei-Lei Chung, Felicia, Tan, Lu Ping, Ahmad, Munirah, Soo-Beng Khoo, Alan, Leong, Chee-Onn
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Cancer therapies Cell culture Cell death Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemoresistance Cisplatin Deoxyribonucleic acid DNA Drug combination Drug dosages Drug resistance Drug Resistance, Neoplasm - genetics Genes Genomes Humans Infections Kinases LCK Lck protein Lymphocytes Lymphocytes - enzymology Metastases Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - enzymology Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - enzymology Nasopharyngeal Neoplasms - pathology NPC Plasmids Protein-tyrosine kinase Protein-Tyrosine Kinases - genetics Proteins Radiation therapy RNA Interference RNA-mediated interference STAT5 Stat5 protein Throat cancer Transcription
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