Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3H)‐ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source a...

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Veröffentlicht in:Advanced synthesis & catalysis 2021-03, Vol.363 (5), p.1417-1426
Hauptverfasser: Wang, Le‐Cheng, Zhang, Yu, Chen, Zhengkai, Wu, Xiao‐Feng
Format: Artikel
Sprache:eng
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2-(trifluoromethyl)quinazolin-4(3H)-ones
Carbon monoxide
carbonylation
Carbonyls
Chemical reduction
Chemical synthesis
Chlorides
N-heterocyclic compounds
Nitro compounds
Palladium
Reagents
trifluoroacetimidoyl chlorides
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creator Wang, Le‐Cheng
Zhang, Yu
Chen, Zhengkai
Wu, Xiao‐Feng
description A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3H)‐ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale.
doi_str_mv 10.1002/adsc.202001502
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subjects 2-(trifluoromethyl)quinazolin-4(3H)-ones
Carbon monoxide
carbonylation
Carbonyls
Chemical reduction
Chemical synthesis
Chlorides
N-heterocyclic compounds
Nitro compounds
Palladium
Reagents
trifluoroacetimidoyl chlorides
title Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds
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