Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses

A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrh...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Parasitology 2021-04, Vol.148 (4), p.408-419
Hauptverfasser: Brainard, Julii, Hammer, Charlotte C., Hunter, Paul R., Katzer, Frank, Hurle, Georgina, Tyler, Kevin
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 419
container_issue 4
container_start_page 408
container_title Parasitology
container_volume 148
creator Brainard, Julii
Hammer, Charlotte C.
Hunter, Paul R.
Katzer, Frank
Hurle, Georgina
Tyler, Kevin
description A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100–150 mcg kg−1 day−1. Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.
doi_str_mv 10.1017/S0031182020002267
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2495151587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0031182020002267</cupid><sourcerecordid>2495151587</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-c5430b90b770164566b0b7ca4d393bebec6f2c9d4742e8e4fe8e009fff9311673</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhYMotlZ_gBsJuB7Nq5kZd1J8QcGFuh4ymZua0pnUJFOZlX_dFKsuRALJhXvOd28OQqeUXFBC88snQjilBSOMEMKYzPfQmApZZgWVdB-Nt-1s2x-hoxCWSSS5ZIdoxDmTVMpijD5ujLFa6QE7g1_Vypl-YTvXAV571_Q6BhxdqmEDXcTO4-hBRaz9sI4urJ23jXXBBmw7XLuNTUatVhsIV1jhMIQIrYpW4wSw8I5V1-AWospUp1ZDgHCMDoxaBTjZvRP0cnvzPLvP5o93D7PreaYFlTHTU8FJXZI6zwmVYiplnWqtRMNLXkMNWhqmy0bkgkEBwqSLkNIYU6aEZM4n6PyLm7711kOI1dL1Pi0RKibKKU2n2Krol0p7F4IHU629bZUfKkqqbeTVn8iT52xH7usWmh_Hd8ZJwHdQ1dYprwX8zv4f-wkh-40N</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2495151587</pqid></control><display><type>article</type><title>Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses</title><source>Cambridge Journals Online</source><source>MEDLINE</source><source>PubMed Central(OpenAccess)</source><creator>Brainard, Julii ; Hammer, Charlotte C. ; Hunter, Paul R. ; Katzer, Frank ; Hurle, Georgina ; Tyler, Kevin</creator><creatorcontrib>Brainard, Julii ; Hammer, Charlotte C. ; Hunter, Paul R. ; Katzer, Frank ; Hurle, Georgina ; Tyler, Kevin</creatorcontrib><description>A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100–150 mcg kg−1 day−1. Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182020002267</identifier><identifier>PMID: 33261668</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Bias ; Calves ; Cattle ; Cattle Diseases - drug therapy ; Cattle Diseases - mortality ; Cattle Diseases - parasitology ; Cattle Diseases - prevention &amp; control ; Coccidiostats - standards ; Coccidiostats - therapeutic use ; Contamination ; Cryptosporidiosis ; Cryptosporidiosis - drug therapy ; Cryptosporidiosis - mortality ; Cryptosporidiosis - prevention &amp; control ; Cryptosporidium ; Cryptosporidium parvum - drug effects ; Cryptosporidium parvum - physiology ; Diarrhea ; Diarrhea - veterinary ; Experiments ; Feces - parasitology ; Grey literature ; Infections ; Intervention ; Kinases ; Mortality ; Oocysts ; Piperidines - standards ; Piperidines - therapeutic use ; Protozoa ; Quinazolinones - standards ; Quinazolinones - therapeutic use ; Shedding ; Systematic review ; Weight Gain</subject><ispartof>Parasitology, 2021-04, Vol.148 (4), p.408-419</ispartof><rights>Copyright © The Author(s) 2020. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-c5430b90b770164566b0b7ca4d393bebec6f2c9d4742e8e4fe8e009fff9311673</citedby><cites>FETCH-LOGICAL-c416t-c5430b90b770164566b0b7ca4d393bebec6f2c9d4742e8e4fe8e009fff9311673</cites><orcidid>0000-0001-5902-4136 ; 0000-0002-0647-8158 ; 0000-0002-5272-7995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182020002267/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33261668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brainard, Julii</creatorcontrib><creatorcontrib>Hammer, Charlotte C.</creatorcontrib><creatorcontrib>Hunter, Paul R.</creatorcontrib><creatorcontrib>Katzer, Frank</creatorcontrib><creatorcontrib>Hurle, Georgina</creatorcontrib><creatorcontrib>Tyler, Kevin</creatorcontrib><title>Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100–150 mcg kg−1 day−1. Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.</description><subject>Animals</subject><subject>Bias</subject><subject>Calves</subject><subject>Cattle</subject><subject>Cattle Diseases - drug therapy</subject><subject>Cattle Diseases - mortality</subject><subject>Cattle Diseases - parasitology</subject><subject>Cattle Diseases - prevention &amp; control</subject><subject>Coccidiostats - standards</subject><subject>Coccidiostats - therapeutic use</subject><subject>Contamination</subject><subject>Cryptosporidiosis</subject><subject>Cryptosporidiosis - drug therapy</subject><subject>Cryptosporidiosis - mortality</subject><subject>Cryptosporidiosis - prevention &amp; control</subject><subject>Cryptosporidium</subject><subject>Cryptosporidium parvum - drug effects</subject><subject>Cryptosporidium parvum - physiology</subject><subject>Diarrhea</subject><subject>Diarrhea - veterinary</subject><subject>Experiments</subject><subject>Feces - parasitology</subject><subject>Grey literature</subject><subject>Infections</subject><subject>Intervention</subject><subject>Kinases</subject><subject>Mortality</subject><subject>Oocysts</subject><subject>Piperidines - standards</subject><subject>Piperidines - therapeutic use</subject><subject>Protozoa</subject><subject>Quinazolinones - standards</subject><subject>Quinazolinones - therapeutic use</subject><subject>Shedding</subject><subject>Systematic review</subject><subject>Weight Gain</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kEtLAzEUhYMotlZ_gBsJuB7Nq5kZd1J8QcGFuh4ymZua0pnUJFOZlX_dFKsuRALJhXvOd28OQqeUXFBC88snQjilBSOMEMKYzPfQmApZZgWVdB-Nt-1s2x-hoxCWSSS5ZIdoxDmTVMpijD5ujLFa6QE7g1_Vypl-YTvXAV571_Q6BhxdqmEDXcTO4-hBRaz9sI4urJ23jXXBBmw7XLuNTUatVhsIV1jhMIQIrYpW4wSw8I5V1-AWospUp1ZDgHCMDoxaBTjZvRP0cnvzPLvP5o93D7PreaYFlTHTU8FJXZI6zwmVYiplnWqtRMNLXkMNWhqmy0bkgkEBwqSLkNIYU6aEZM4n6PyLm7711kOI1dL1Pi0RKibKKU2n2Krol0p7F4IHU629bZUfKkqqbeTVn8iT52xH7usWmh_Hd8ZJwHdQ1dYprwX8zv4f-wkh-40N</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Brainard, Julii</creator><creator>Hammer, Charlotte C.</creator><creator>Hunter, Paul R.</creator><creator>Katzer, Frank</creator><creator>Hurle, Georgina</creator><creator>Tyler, Kevin</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-5902-4136</orcidid><orcidid>https://orcid.org/0000-0002-0647-8158</orcidid><orcidid>https://orcid.org/0000-0002-5272-7995</orcidid></search><sort><creationdate>202104</creationdate><title>Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses</title><author>Brainard, Julii ; Hammer, Charlotte C. ; Hunter, Paul R. ; Katzer, Frank ; Hurle, Georgina ; Tyler, Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-c5430b90b770164566b0b7ca4d393bebec6f2c9d4742e8e4fe8e009fff9311673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Bias</topic><topic>Calves</topic><topic>Cattle</topic><topic>Cattle Diseases - drug therapy</topic><topic>Cattle Diseases - mortality</topic><topic>Cattle Diseases - parasitology</topic><topic>Cattle Diseases - prevention &amp; control</topic><topic>Coccidiostats - standards</topic><topic>Coccidiostats - therapeutic use</topic><topic>Contamination</topic><topic>Cryptosporidiosis</topic><topic>Cryptosporidiosis - drug therapy</topic><topic>Cryptosporidiosis - mortality</topic><topic>Cryptosporidiosis - prevention &amp; control</topic><topic>Cryptosporidium</topic><topic>Cryptosporidium parvum - drug effects</topic><topic>Cryptosporidium parvum - physiology</topic><topic>Diarrhea</topic><topic>Diarrhea - veterinary</topic><topic>Experiments</topic><topic>Feces - parasitology</topic><topic>Grey literature</topic><topic>Infections</topic><topic>Intervention</topic><topic>Kinases</topic><topic>Mortality</topic><topic>Oocysts</topic><topic>Piperidines - standards</topic><topic>Piperidines - therapeutic use</topic><topic>Protozoa</topic><topic>Quinazolinones - standards</topic><topic>Quinazolinones - therapeutic use</topic><topic>Shedding</topic><topic>Systematic review</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brainard, Julii</creatorcontrib><creatorcontrib>Hammer, Charlotte C.</creatorcontrib><creatorcontrib>Hunter, Paul R.</creatorcontrib><creatorcontrib>Katzer, Frank</creatorcontrib><creatorcontrib>Hurle, Georgina</creatorcontrib><creatorcontrib>Tyler, Kevin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brainard, Julii</au><au>Hammer, Charlotte C.</au><au>Hunter, Paul R.</au><au>Katzer, Frank</au><au>Hurle, Georgina</au><au>Tyler, Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2021-04</date><risdate>2021</risdate><volume>148</volume><issue>4</issue><spage>408</spage><epage>419</epage><pages>408-419</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><abstract>A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100–150 mcg kg−1 day−1. Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33261668</pmid><doi>10.1017/S0031182020002267</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5902-4136</orcidid><orcidid>https://orcid.org/0000-0002-0647-8158</orcidid><orcidid>https://orcid.org/0000-0002-5272-7995</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0031-1820
ispartof Parasitology, 2021-04, Vol.148 (4), p.408-419
issn 0031-1820
1469-8161
language eng
recordid cdi_proquest_journals_2495151587
source Cambridge Journals Online; MEDLINE; PubMed Central(OpenAccess)
subjects Animals
Bias
Calves
Cattle
Cattle Diseases - drug therapy
Cattle Diseases - mortality
Cattle Diseases - parasitology
Cattle Diseases - prevention & control
Coccidiostats - standards
Coccidiostats - therapeutic use
Contamination
Cryptosporidiosis
Cryptosporidiosis - drug therapy
Cryptosporidiosis - mortality
Cryptosporidiosis - prevention & control
Cryptosporidium
Cryptosporidium parvum - drug effects
Cryptosporidium parvum - physiology
Diarrhea
Diarrhea - veterinary
Experiments
Feces - parasitology
Grey literature
Infections
Intervention
Kinases
Mortality
Oocysts
Piperidines - standards
Piperidines - therapeutic use
Protozoa
Quinazolinones - standards
Quinazolinones - therapeutic use
Shedding
Systematic review
Weight Gain
title Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A11%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20halofuginone%20products%20to%20prevent%20or%20treat%20cryptosporidiosis%20in%20bovine%20calves:%20a%20systematic%20review%20and%20meta-analyses&rft.jtitle=Parasitology&rft.au=Brainard,%20Julii&rft.date=2021-04&rft.volume=148&rft.issue=4&rft.spage=408&rft.epage=419&rft.pages=408-419&rft.issn=0031-1820&rft.eissn=1469-8161&rft_id=info:doi/10.1017/S0031182020002267&rft_dat=%3Cproquest_cross%3E2495151587%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2495151587&rft_id=info:pmid/33261668&rft_cupid=10_1017_S0031182020002267&rfr_iscdi=true