Tracking break-induced replication shows that it stalls at roadblocks

Break-induced replication (BIR) repairs one-ended double-strand breaks in DNA similar to those formed by replication collapse or telomere erosion, and it has been implicated in the initiation of genome instability in cancer and other human diseases 1 , 2 . Previous studies have defined the enzymes t...

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Veröffentlicht in:	Nature (London) 2021-02, Vol.590 (7847), p.655-659
Hauptverfasser:	Liu, Liping, Yan, Zhenxin, Osia, Beth A., Twarowski, Jerzy, Sun, Luyang, Kramara, Juraj, Lee, Rosemary S., Kumar, Sandeep, Elango, Rajula, Li, Hanzeng, Dang, Weiwei, Ira, Grzegorz, Malkova, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/15 45/23 45/70 45/77 45/90 631/208/211 631/208/737 631/337/1427 631/337/151/1431 64 Chromosome rearrangements Chromosomes Chromosomes, Fungal - genetics Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks, Double-Stranded DNA damage DNA Helicases - deficiency DNA Primase - metabolism DNA Repair DNA Replication DNA, Fungal - biosynthesis DNA-Directed DNA Polymerase - deficiency Genetic research Genetic transcription Genomes Genomic Instability Humanities and Social Sciences Kinetics multidisciplinary Mutagenesis Mutation Primase Replication S Phase Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Science Science (multidisciplinary) Synthesis Telomere - genetics Telomeres Time Factors Transcription initiation Transcription, Genetic
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