Effect of the drug cyclophosphamide on the activity of porcine kidney betaine aldehyde dehydrogenase

The enzyme betaine aldehyde dehydrogenase (BADH EC 1.2.1.8) catalyzes the synthesis of glycine betaine (GB), an osmolyte and osmoprotectant. Also, it participates in several metabolic pathways in humans. All BADHs known have cysteine in the active site involved in the aldehyde binding, whereas the p...

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Veröffentlicht in:	Molecular and cellular biochemistry 2021-03, Vol.476 (3), p.1467-1475
Hauptverfasser:	Cruz-Valencia, Ramses, Arvizu-Flores, Aldo A., Rosas-Rodríguez, Jesús A., Valenzuela-Soto, Elisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase Aldehydes Amino acids Biochemistry Biomedical and Life Sciences Cardiology Chemical synthesis Chlorine Cyclophosphamide Cysteine Deactivation Dehydrogenase Dehydrogenases Disulfide bonds Dithiothreitol Enzymatic activity Enzyme activity Enzymes Ethylenediaminetetraacetic acid Glutathione Glycine Glycine betaine Inactivation Kidneys Life Sciences Medical Biochemistry Metabolic pathways Molecular docking NAD NADH Nicotinamide adenine dinucleotide Oncology Oxidation Reducing agents Substrates
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