Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report
Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge...
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| Veröffentlicht in: | Esophagus : official journal of the Japan Esophageal Society 2016-07, Vol.13 (3), p.301-305 |
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| creator | Korehisa, Shotaro Saeki, Hiroshi Nakashima, Yuichiro Nakaji, Yu Tsutsumi, Satoshi Yukaya, Takafumi Tajiri, Hirotada Kasagi, Yuta Sonoda, Hideto Sugiyama, Masahiko Ohgaki, Kippei Oki, Eiji Hirahashi, Minako Yamamoto, Hidetaka Maehara, Yoshihiko |
| description | Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST. |
| doi_str_mv | 10.1007/s10388-016-0525-9 |
| format | Article |
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This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. 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This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.</description><subject>Biopsy</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Endoscopy</subject><subject>Esophageal cancer</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Gastrointestinal cancer</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Surgical Oncology</subject><subject>Thoracic Surgery</subject><subject>Throat surgery</subject><subject>Tumors</subject><issn>1612-9059</issn><issn>1612-9067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtLxDAUhYMoOI7-AHcB19U8mrRxJ4MvGHGj65AmNzMZOk1NWtB_b4eKrlyde-Gcw-FD6JKSa0pIdZMp4XVdECoLIpgo1BFaUElZoYisjn9voU7RWc47Qjgra75A_iV8gsO5D51rAZvOYejDsIU2xOCwhbbFw1cPeGPykGLoBshD6EyLD-9-0mHcx4Sjx1MIQ4791mzGfIsNtiYDTtDHNJyjE2_aDBc_ukTvD_dvq6di_fr4vLpbF5aXZCi8kYJJY63yQllfMVpy0SjvwJnaA2PSO28q2jSNtxKEA6UM5bySAiynDV-iq7m3T_FjnKbqXRzTNDdrVqpSVFVVq8lFZ5dNMecEXvcp7E360pToA04949QTTn3AqQ8ZNmfy5O02kP6a_w99A3tXeqI</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Korehisa, Shotaro</creator><creator>Saeki, Hiroshi</creator><creator>Nakashima, Yuichiro</creator><creator>Nakaji, Yu</creator><creator>Tsutsumi, Satoshi</creator><creator>Yukaya, Takafumi</creator><creator>Tajiri, Hirotada</creator><creator>Kasagi, Yuta</creator><creator>Sonoda, Hideto</creator><creator>Sugiyama, Masahiko</creator><creator>Ohgaki, Kippei</creator><creator>Oki, Eiji</creator><creator>Hirahashi, Minako</creator><creator>Yamamoto, Hidetaka</creator><creator>Maehara, Yoshihiko</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160701</creationdate><title>Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report</title><author>Korehisa, Shotaro ; 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This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. 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| subjects | Biopsy Case Report Case reports Chemotherapy Endoscopy Esophageal cancer Esophagus Gastroenterology Gastrointestinal cancer Medical diagnosis Medicine Medicine & Public Health Surgical Oncology Thoracic Surgery Throat surgery Tumors |
| title | Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report |
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