Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain
Background Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of...
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| Veröffentlicht in: | Psychopharmacology 2021-03, Vol.238 (3), p.877-886 |
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| creator | Saffarpour, Sepideh Janzadeh, Atousa Rahimi, Behnaz Ramezani, Fatemeh Nasirinezhad, Farinaz |
| description | Background
Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of neuropathic pain and its comorbidity.
Methods
Adult male albino Wistar rats (
n
= 32) were randomly divided into four experimental groups: CCI+ nanocurcumin, CCI + vehicle, sham + nanocurcumin, and sham + vehicle. Neuropathic pain induced by a chronic constriction injury of the sciatic nerve. Nanocurcumin or vehicle was injected intraperitoneally for 10 days. Behavioral assessment achieved to evaluate pain threshold in the von Frey test and radiant heat test, also spatial learning and memory examined by the Morris water maze (MWM) test. To explore the possible relation, IL-1β, and TNF-α levels of the hippocampus measured by enzyme-linked immunosorbent assay (ELISA).
Results
Our data showed that CCI caused neuropathic pain-related behaviors and spatial learning and memory disorders in rats. Chronic treatment with nanocurcumin significantly increased pain threshold (
P
|
| doi_str_mv | 10.1007/s00213-020-05739-x |
| format | Article |
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Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of neuropathic pain and its comorbidity.
Methods
Adult male albino Wistar rats (
n
= 32) were randomly divided into four experimental groups: CCI+ nanocurcumin, CCI + vehicle, sham + nanocurcumin, and sham + vehicle. Neuropathic pain induced by a chronic constriction injury of the sciatic nerve. Nanocurcumin or vehicle was injected intraperitoneally for 10 days. Behavioral assessment achieved to evaluate pain threshold in the von Frey test and radiant heat test, also spatial learning and memory examined by the Morris water maze (MWM) test. To explore the possible relation, IL-1β, and TNF-α levels of the hippocampus measured by enzyme-linked immunosorbent assay (ELISA).
Results
Our data showed that CCI caused neuropathic pain-related behaviors and spatial learning and memory disorders in rats. Chronic treatment with nanocurcumin significantly increased pain threshold (
P
< 0.001;
F
= 27.63,
F
= 20.58), improved spatial memory (
P
< 0.01;
F
= 47.37), and decreased the hippocampal levels of IL-1β (
P
< 0.001;
F
= 33.57) and TNF-α (
P
< 0.01;
F
= 7.25) in CCI rats.
Conclusion
Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1β and TNF-α levels in the hippocampus in CCI rats. Nanocurcumin may be potentially providing a therapeutic alternative for the treatment of neuropathic pain and its memory impairment comorbidity.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-020-05739-x</identifier><identifier>PMID: 33404738</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analgesics - administration & dosage ; Analgesics - chemistry ; Analgesics - therapeutic use ; Animal memory ; Animal models ; Animals ; Behavior, Animal - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Cognitive ability ; Comorbidity ; Constriction ; Curcumin - administration & dosage ; Curcumin - chemistry ; Curcumin - therapeutic use ; Disease Models, Animal ; Enzyme-linked immunosorbent assay ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; IL-1β ; Interleukin-1beta - metabolism ; Male ; Memory ; Memory Disorders - complications ; Memory Disorders - drug therapy ; Memory Disorders - metabolism ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Neuralgia ; Neuralgia - complications ; Neuralgia - drug therapy ; Neuralgia - metabolism ; Neurosciences ; Original Investigation ; Pain ; Pain perception ; Pain Threshold - drug effects ; Pharmacology/Toxicology ; Psychiatry ; Rats ; Rats, Wistar ; Sciatic nerve ; Sciatic Nerve - drug effects ; Sciatic Nerve - injuries ; Spatial discrimination learning ; Spatial memory ; Spatial Memory - drug effects ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-α</subject><ispartof>Psychopharmacology, 2021-03, Vol.238 (3), p.877-886</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-46cd2b612b4a6e1980a8631d4723cf566874bac7ca1d354af8dd2692c3efa9473</citedby><cites>FETCH-LOGICAL-c375t-46cd2b612b4a6e1980a8631d4723cf566874bac7ca1d354af8dd2692c3efa9473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-020-05739-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-020-05739-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33404738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saffarpour, Sepideh</creatorcontrib><creatorcontrib>Janzadeh, Atousa</creatorcontrib><creatorcontrib>Rahimi, Behnaz</creatorcontrib><creatorcontrib>Ramezani, Fatemeh</creatorcontrib><creatorcontrib>Nasirinezhad, Farinaz</creatorcontrib><title>Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Background
Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of neuropathic pain and its comorbidity.
Methods
Adult male albino Wistar rats (
n
= 32) were randomly divided into four experimental groups: CCI+ nanocurcumin, CCI + vehicle, sham + nanocurcumin, and sham + vehicle. Neuropathic pain induced by a chronic constriction injury of the sciatic nerve. Nanocurcumin or vehicle was injected intraperitoneally for 10 days. Behavioral assessment achieved to evaluate pain threshold in the von Frey test and radiant heat test, also spatial learning and memory examined by the Morris water maze (MWM) test. To explore the possible relation, IL-1β, and TNF-α levels of the hippocampus measured by enzyme-linked immunosorbent assay (ELISA).
Results
Our data showed that CCI caused neuropathic pain-related behaviors and spatial learning and memory disorders in rats. Chronic treatment with nanocurcumin significantly increased pain threshold (
P
< 0.001;
F
= 27.63,
F
= 20.58), improved spatial memory (
P
< 0.01;
F
= 47.37), and decreased the hippocampal levels of IL-1β (
P
< 0.001;
F
= 33.57) and TNF-α (
P
< 0.01;
F
= 7.25) in CCI rats.
Conclusion
Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1β and TNF-α levels in the hippocampus in CCI rats. Nanocurcumin may be potentially providing a therapeutic alternative for the treatment of neuropathic pain and its memory impairment comorbidity.</description><subject>Analgesics - administration & dosage</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - therapeutic use</subject><subject>Animal memory</subject><subject>Animal models</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Constriction</subject><subject>Curcumin - administration & dosage</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>IL-1β</subject><subject>Interleukin-1beta - metabolism</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - complications</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - metabolism</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Neuralgia</subject><subject>Neuralgia - complications</subject><subject>Neuralgia - drug therapy</subject><subject>Neuralgia - metabolism</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Pain Threshold - drug effects</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sciatic nerve</subject><subject>Sciatic Nerve - drug effects</subject><subject>Sciatic Nerve - injuries</subject><subject>Spatial discrimination learning</subject><subject>Spatial memory</subject><subject>Spatial Memory - drug effects</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-α</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UctuEzEUtRAVDYUfYIEssa3Br3ktUdRCpahs2vXIY99hHI3twZ6Jms-Cz2DRb8JpAuzqjWWd170-CL1j9COjtPqUKOVMEMopoUUlGvLwAq2YFJxwWvGXaEWpEESwoj5Hr1Pa0nxkLV-hcyEklZWoV-j3eojBW4298kEvUS_OejxHULMDP2PlYLQhqhkSnpT1JMKYHwZ3MKhdRi6xdVMMu4ynSc1WjdiBC3F_iZU3OIJZdMYGO01BKzdlfIQdjAmHHt9sCHv89US8u71-_IkP2QNgfRpKB5_maPVsg8_Ydol77IKB8SD2sMSQI4dMPIz2Bp31akzw9nRfoPvrq7v1V7L59uVm_XlDtKiKmchSG96VjHdSlcCamqq6FMzIigvdF2VZV7JTutKKGVFI1dfG8LLhWkCvmvxrF-jD0Tev_WOBNLfbsESfI1suG1HXopQys_iRpWNIKULfTtE6Ffcto-2hvvZYX5vra5_qax-y6P3JeukcmH-Sv31lgjgSUob8d4j_s5-x_QN2xqxW</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Saffarpour, Sepideh</creator><creator>Janzadeh, Atousa</creator><creator>Rahimi, Behnaz</creator><creator>Ramezani, Fatemeh</creator><creator>Nasirinezhad, Farinaz</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20210301</creationdate><title>Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain</title><author>Saffarpour, Sepideh ; Janzadeh, Atousa ; Rahimi, Behnaz ; Ramezani, Fatemeh ; Nasirinezhad, Farinaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-46cd2b612b4a6e1980a8631d4723cf566874bac7ca1d354af8dd2692c3efa9473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analgesics - administration & dosage</topic><topic>Analgesics - chemistry</topic><topic>Analgesics - therapeutic use</topic><topic>Animal memory</topic><topic>Animal models</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Constriction</topic><topic>Curcumin - administration & dosage</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>IL-1β</topic><topic>Interleukin-1beta - metabolism</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - complications</topic><topic>Memory Disorders - drug therapy</topic><topic>Memory Disorders - metabolism</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Neuralgia</topic><topic>Neuralgia - complications</topic><topic>Neuralgia - drug therapy</topic><topic>Neuralgia - metabolism</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Pain Threshold - drug effects</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sciatic nerve</topic><topic>Sciatic Nerve - drug effects</topic><topic>Sciatic Nerve - injuries</topic><topic>Spatial discrimination learning</topic><topic>Spatial memory</topic><topic>Spatial Memory - drug effects</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saffarpour, Sepideh</creatorcontrib><creatorcontrib>Janzadeh, Atousa</creatorcontrib><creatorcontrib>Rahimi, Behnaz</creatorcontrib><creatorcontrib>Ramezani, Fatemeh</creatorcontrib><creatorcontrib>Nasirinezhad, Farinaz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saffarpour, Sepideh</au><au>Janzadeh, Atousa</au><au>Rahimi, Behnaz</au><au>Ramezani, Fatemeh</au><au>Nasirinezhad, Farinaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>238</volume><issue>3</issue><spage>877</spage><epage>886</epage><pages>877-886</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Background
Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of neuropathic pain and its comorbidity.
Methods
Adult male albino Wistar rats (
n
= 32) were randomly divided into four experimental groups: CCI+ nanocurcumin, CCI + vehicle, sham + nanocurcumin, and sham + vehicle. Neuropathic pain induced by a chronic constriction injury of the sciatic nerve. Nanocurcumin or vehicle was injected intraperitoneally for 10 days. Behavioral assessment achieved to evaluate pain threshold in the von Frey test and radiant heat test, also spatial learning and memory examined by the Morris water maze (MWM) test. To explore the possible relation, IL-1β, and TNF-α levels of the hippocampus measured by enzyme-linked immunosorbent assay (ELISA).
Results
Our data showed that CCI caused neuropathic pain-related behaviors and spatial learning and memory disorders in rats. Chronic treatment with nanocurcumin significantly increased pain threshold (
P
< 0.001;
F
= 27.63,
F
= 20.58), improved spatial memory (
P
< 0.01;
F
= 47.37), and decreased the hippocampal levels of IL-1β (
P
< 0.001;
F
= 33.57) and TNF-α (
P
< 0.01;
F
= 7.25) in CCI rats.
Conclusion
Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1β and TNF-α levels in the hippocampus in CCI rats. Nanocurcumin may be potentially providing a therapeutic alternative for the treatment of neuropathic pain and its memory impairment comorbidity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33404738</pmid><doi>10.1007/s00213-020-05739-x</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2021-03, Vol.238 (3), p.877-886 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analgesics - administration & dosage Analgesics - chemistry Analgesics - therapeutic use Animal memory Animal models Animals Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Cognitive ability Comorbidity Constriction Curcumin - administration & dosage Curcumin - chemistry Curcumin - therapeutic use Disease Models, Animal Enzyme-linked immunosorbent assay Hippocampus Hippocampus - drug effects Hippocampus - metabolism IL-1β Interleukin-1beta - metabolism Male Memory Memory Disorders - complications Memory Disorders - drug therapy Memory Disorders - metabolism Nanoparticles - administration & dosage Nanoparticles - chemistry Neuralgia Neuralgia - complications Neuralgia - drug therapy Neuralgia - metabolism Neurosciences Original Investigation Pain Pain perception Pain Threshold - drug effects Pharmacology/Toxicology Psychiatry Rats Rats, Wistar Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - injuries Spatial discrimination learning Spatial memory Spatial Memory - drug effects Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α |
| title | Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1β and TNFα in the chronic constriction injury model of neuropathic pain |
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