A one-pot synthesis of 2-aminothiazoles via the coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system

A series of 2-aminothiazoles is prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic α-haloketones and the use of an acid-binding agent, thus provid...

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Veröffentlicht in:	Journal of chemical research 2021-01, Vol.45 (1-2), p.89-94
Hauptverfasser:	Zhang, Qian, Wu, Jiefei, Pan, Zexi, Zhang, Wen, Zhou, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Coupling Dimethyl sulfoxide Ketones Sulfoxides Thioureas
Online-Zugang:	Volltext
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