A DNA nanodevice-based vaccine for cancer immunotherapy

A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvant...

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Veröffentlicht in:	Nature materials 2021-03, Vol.20 (3), p.421-430
Hauptverfasser:	Liu, Shaoli, Jiang, Qiao, Zhao, Xiao, Zhao, Ruifang, Wang, Yuanning, Wang, Yiming, Liu, Jianbing, Shang, Yingxu, Zhao, Shuai, Wu, Tiantian, Zhang, Yinlong, Nie, Guangjun, Ding, Baoquan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 639/301/357/341 639/925/926/1048 Adjuvants Adjuvants, Immunologic - administration & dosage Animals Antigen Presentation Antigens Bacteriophage M13 - genetics Biocompatibility Biomaterials Cancer Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Chemistry and Materials Science Condensed Matter Physics Cytotoxicity Cytotoxicity Tests, Immunologic Dendritic Cells - drug effects Dendritic Cells - immunology Deoxyribonucleic acid DNA Hydrogen-Ion Concentration Immune response Immune system Immunotherapy Immunotherapy - methods Locking Lymphatic Metastasis - prevention & control Lymphocytes Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Lysosomes Materials Science Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Nanostructure Nanotechnology Nanotechnology devices Optical and Electronic Materials Robust control Toxicity Tumors Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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