A DNA nanodevice-based vaccine for cancer immunotherapy
A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvant...
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| Veröffentlicht in: | Nature materials 2021-03, Vol.20 (3), p.421-430 |
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| creator | Liu, Shaoli Jiang, Qiao Zhao, Xiao Zhao, Ruifang Wang, Yuanning Wang, Yiming Liu, Jianbing Shang, Yingxu Zhao, Shuai Wu, Tiantian Zhang, Yinlong Nie, Guangjun Ding, Baoquan |
| description | A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvants and an antigen peptide within the inner cavity of a tubular DNA nanostructure that can be activated in the subcellular environment to trigger T-cell activation and cancer cytotoxicity. The integration of low pH-responsive DNA ‘locking strands’ outside the nanostructures enables the opening of the vaccine in lysosomes in antigen-presenting cells, exposing adjuvants and antigens to activate a strong immune response. The DNA nanodevice vaccine elicited a potent antigen-specific T-cell response, with subsequent tumour regression in mouse cancer models. Nanodevice vaccination generated long-term T-cell responses that potently protected the mice against tumour rechallenge.
A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis. |
| doi_str_mv | 10.1038/s41563-020-0793-6 |
| format | Article |
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A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis.</description><identifier>ISSN: 1476-1122</identifier><identifier>EISSN: 1476-4660</identifier><identifier>DOI: 10.1038/s41563-020-0793-6</identifier><identifier>PMID: 32895504</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1059/2325 ; 639/301/357/341 ; 639/925/926/1048 ; Adjuvants ; Adjuvants, Immunologic - administration & dosage ; Animals ; Antigen Presentation ; Antigens ; Bacteriophage M13 - genetics ; Biocompatibility ; Biomaterials ; Cancer ; Cancer Vaccines - administration & dosage ; Cancer Vaccines - genetics ; Cancer Vaccines - immunology ; Chemistry and Materials Science ; Condensed Matter Physics ; Cytotoxicity ; Cytotoxicity Tests, Immunologic ; Dendritic Cells - drug effects ; Dendritic Cells - immunology ; Deoxyribonucleic acid ; DNA ; Hydrogen-Ion Concentration ; Immune response ; Immune system ; Immunotherapy ; Immunotherapy - methods ; Locking ; Lymphatic Metastasis - prevention & control ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - drug effects ; Lymphocytes, Tumor-Infiltrating - immunology ; Lysosomes ; Materials Science ; Melanoma, Experimental - immunology ; Melanoma, Experimental - pathology ; Melanoma, Experimental - therapy ; Mice ; Mice, Inbred C57BL ; Nanostructure ; Nanotechnology ; Nanotechnology devices ; Optical and Electronic Materials ; Robust control ; Toxicity ; Tumors ; Vaccines ; Vaccines, DNA - administration & dosage ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology</subject><ispartof>Nature materials, 2021-03, Vol.20 (3), p.421-430</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-2ff80c29807349d758c610ccf38c1be4bb69042fc852c13c16881e6655c5f4033</citedby><cites>FETCH-LOGICAL-c372t-2ff80c29807349d758c610ccf38c1be4bb69042fc852c13c16881e6655c5f4033</cites><orcidid>0000-0001-5040-9793 ; 0000-0003-1095-8872</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32895504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Shaoli</creatorcontrib><creatorcontrib>Jiang, Qiao</creatorcontrib><creatorcontrib>Zhao, Xiao</creatorcontrib><creatorcontrib>Zhao, Ruifang</creatorcontrib><creatorcontrib>Wang, Yuanning</creatorcontrib><creatorcontrib>Wang, Yiming</creatorcontrib><creatorcontrib>Liu, Jianbing</creatorcontrib><creatorcontrib>Shang, Yingxu</creatorcontrib><creatorcontrib>Zhao, Shuai</creatorcontrib><creatorcontrib>Wu, Tiantian</creatorcontrib><creatorcontrib>Zhang, Yinlong</creatorcontrib><creatorcontrib>Nie, Guangjun</creatorcontrib><creatorcontrib>Ding, Baoquan</creatorcontrib><title>A DNA nanodevice-based vaccine for cancer immunotherapy</title><title>Nature materials</title><addtitle>Nat. Mater</addtitle><addtitle>Nat Mater</addtitle><description>A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvants and an antigen peptide within the inner cavity of a tubular DNA nanostructure that can be activated in the subcellular environment to trigger T-cell activation and cancer cytotoxicity. The integration of low pH-responsive DNA ‘locking strands’ outside the nanostructures enables the opening of the vaccine in lysosomes in antigen-presenting cells, exposing adjuvants and antigens to activate a strong immune response. The DNA nanodevice vaccine elicited a potent antigen-specific T-cell response, with subsequent tumour regression in mouse cancer models. Nanodevice vaccination generated long-term T-cell responses that potently protected the mice against tumour rechallenge.
A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis.</description><subject>631/67/1059/2325</subject><subject>639/301/357/341</subject><subject>639/925/926/1048</subject><subject>Adjuvants</subject><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Animals</subject><subject>Antigen Presentation</subject><subject>Antigens</subject><subject>Bacteriophage M13 - genetics</subject><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Cancer</subject><subject>Cancer Vaccines - administration & dosage</subject><subject>Cancer Vaccines - genetics</subject><subject>Cancer Vaccines - immunology</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter Physics</subject><subject>Cytotoxicity</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Dendritic Cells - drug effects</subject><subject>Dendritic Cells - immunology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Hydrogen-Ion Concentration</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Locking</subject><subject>Lymphatic Metastasis - prevention & control</subject><subject>Lymphocytes</subject><subject>Lymphocytes, Tumor-Infiltrating - drug effects</subject><subject>Lymphocytes, Tumor-Infiltrating - immunology</subject><subject>Lysosomes</subject><subject>Materials Science</subject><subject>Melanoma, Experimental - immunology</subject><subject>Melanoma, Experimental - pathology</subject><subject>Melanoma, Experimental - therapy</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Nanotechnology devices</subject><subject>Optical and Electronic Materials</subject><subject>Robust control</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Vaccines</subject><subject>Vaccines, DNA - 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Mater</stitle><addtitle>Nat Mater</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>20</volume><issue>3</issue><spage>421</spage><epage>430</epage><pages>421-430</pages><issn>1476-1122</issn><eissn>1476-4660</eissn><abstract>A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvants and an antigen peptide within the inner cavity of a tubular DNA nanostructure that can be activated in the subcellular environment to trigger T-cell activation and cancer cytotoxicity. The integration of low pH-responsive DNA ‘locking strands’ outside the nanostructures enables the opening of the vaccine in lysosomes in antigen-presenting cells, exposing adjuvants and antigens to activate a strong immune response. The DNA nanodevice vaccine elicited a potent antigen-specific T-cell response, with subsequent tumour regression in mouse cancer models. Nanodevice vaccination generated long-term T-cell responses that potently protected the mice against tumour rechallenge.
A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32895504</pmid><doi>10.1038/s41563-020-0793-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5040-9793</orcidid><orcidid>https://orcid.org/0000-0003-1095-8872</orcidid></addata></record> |
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| subjects | 631/67/1059/2325 639/301/357/341 639/925/926/1048 Adjuvants Adjuvants, Immunologic - administration & dosage Animals Antigen Presentation Antigens Bacteriophage M13 - genetics Biocompatibility Biomaterials Cancer Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Chemistry and Materials Science Condensed Matter Physics Cytotoxicity Cytotoxicity Tests, Immunologic Dendritic Cells - drug effects Dendritic Cells - immunology Deoxyribonucleic acid DNA Hydrogen-Ion Concentration Immune response Immune system Immunotherapy Immunotherapy - methods Locking Lymphatic Metastasis - prevention & control Lymphocytes Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Lysosomes Materials Science Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Nanostructure Nanotechnology Nanotechnology devices Optical and Electronic Materials Robust control Toxicity Tumors Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology |
| title | A DNA nanodevice-based vaccine for cancer immunotherapy |
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