Chitosan/nanocellulose‐based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery
Bionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under‐exploited. Therefore, t...
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| Veröffentlicht in: | Journal of applied polymer science 2021-06, Vol.138 (21), p.n/a |
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| creator | Riccio, Bruno Vincenzo Fiod Klosowski, Ana Beatriz Prestes, Eduardo Sousa, Taynara Barbosa Assunção Morais, Laís Caroline Lemes, Bruna Mikulis Beltrame, Flávio Luís Campos, Patrícia Mazureki Ferrari, Priscileila Colerato |
| description | Bionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under‐exploited. Therefore, this work aimed to design chitosan/nanocellulose‐based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi‐occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non‐infectious dry wounds, and infectious wounds. |
| doi_str_mv | 10.1002/app.50468 |
| format | Article |
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However, the development of these films as controlled drug release dressings is still under‐exploited. Therefore, this work aimed to design chitosan/nanocellulose‐based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi‐occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non‐infectious dry wounds, and infectious wounds.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.50468</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Active control ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biodegradability ; biodegradable ; Biodegradable materials ; biomedical applications ; Biomedical materials ; Chitosan ; drug delivery systems ; Materials science ; Nanocrystals ; Polymers</subject><ispartof>Journal of applied polymer science, 2021-06, Vol.138 (21), p.n/a</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3348-bffe3b8d7a25a08d65ef302f9370ff131fc081d2d395742ce59d3490f8798dde3</citedby><cites>FETCH-LOGICAL-c3348-bffe3b8d7a25a08d65ef302f9370ff131fc081d2d395742ce59d3490f8798dde3</cites><orcidid>0000-0002-2370-0662 ; 0000-0002-7104-2123 ; 0000-0001-7067-5802 ; 0000-0003-2659-8023 ; 0000-0002-4285-6646 ; 0000-0002-3189-2545</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.50468$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.50468$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Riccio, Bruno Vincenzo Fiod</creatorcontrib><creatorcontrib>Klosowski, Ana Beatriz</creatorcontrib><creatorcontrib>Prestes, Eduardo</creatorcontrib><creatorcontrib>Sousa, Taynara Barbosa</creatorcontrib><creatorcontrib>Assunção Morais, Laís Caroline</creatorcontrib><creatorcontrib>Lemes, Bruna Mikulis</creatorcontrib><creatorcontrib>Beltrame, Flávio Luís</creatorcontrib><creatorcontrib>Campos, Patrícia Mazureki</creatorcontrib><creatorcontrib>Ferrari, Priscileila Colerato</creatorcontrib><title>Chitosan/nanocellulose‐based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery</title><title>Journal of applied polymer science</title><description>Bionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. 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In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non‐infectious dry wounds, and infectious wounds.</description><subject>Active control</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biodegradability</subject><subject>biodegradable</subject><subject>Biodegradable materials</subject><subject>biomedical applications</subject><subject>Biomedical materials</subject><subject>Chitosan</subject><subject>drug delivery systems</subject><subject>Materials science</subject><subject>Nanocrystals</subject><subject>Polymers</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EEqWw4A8isWKR1o887GVV8ZIq0QWsLSceq66cONgpqKz4BL6RLyFt2LIa6d4zM9JB6JrgGcGYzlXXzXKcFfwETQgWZZoVlJ-iydCRlAuRn6OLGLcYE5LjYoLicmN7H1U7b1Xra3Bu53yEn6_vSkXQSWX9sfBN56PtITHWNTExPiS1b_vgnTtQ0KsG-o2KvoVEtTqJ1r1DSOLOGaWt-rRDrsHZIdxfojOjXISrvzlFr_d3L8vHdPX88LRcrNKasYynlTHAKq5LRXOFuS5yMAxTI1iJjSGMmBpzoqlmIi8zWkMuNMsENrwUXGtgU3Qz3u2Cf9tB7OXW70I7vJQ0E1RkvBBkoG5Hqg4-xgBGdsE2KuwlwfLgVA5O5dHpwM5H9sM62P8PysV6PW78ApB4fKw</recordid><startdate>20210605</startdate><enddate>20210605</enddate><creator>Riccio, Bruno Vincenzo Fiod</creator><creator>Klosowski, Ana Beatriz</creator><creator>Prestes, Eduardo</creator><creator>Sousa, Taynara Barbosa</creator><creator>Assunção Morais, Laís Caroline</creator><creator>Lemes, Bruna Mikulis</creator><creator>Beltrame, Flávio Luís</creator><creator>Campos, Patrícia Mazureki</creator><creator>Ferrari, Priscileila Colerato</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-2370-0662</orcidid><orcidid>https://orcid.org/0000-0002-7104-2123</orcidid><orcidid>https://orcid.org/0000-0001-7067-5802</orcidid><orcidid>https://orcid.org/0000-0003-2659-8023</orcidid><orcidid>https://orcid.org/0000-0002-4285-6646</orcidid><orcidid>https://orcid.org/0000-0002-3189-2545</orcidid></search><sort><creationdate>20210605</creationdate><title>Chitosan/nanocellulose‐based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery</title><author>Riccio, Bruno Vincenzo Fiod ; 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However, the development of these films as controlled drug release dressings is still under‐exploited. Therefore, this work aimed to design chitosan/nanocellulose‐based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi‐occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non‐infectious dry wounds, and infectious wounds.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.50468</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2370-0662</orcidid><orcidid>https://orcid.org/0000-0002-7104-2123</orcidid><orcidid>https://orcid.org/0000-0001-7067-5802</orcidid><orcidid>https://orcid.org/0000-0003-2659-8023</orcidid><orcidid>https://orcid.org/0000-0002-4285-6646</orcidid><orcidid>https://orcid.org/0000-0002-3189-2545</orcidid></addata></record> |
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| subjects | Active control Antiinfectives and antibacterials Antimicrobial agents Biodegradability biodegradable Biodegradable materials biomedical applications Biomedical materials Chitosan drug delivery systems Materials science Nanocrystals Polymers |
| title | Chitosan/nanocellulose‐based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
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