Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins

The methanolic extract of the leaves of artichoke ( Cynara scolymus L.) was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Among the constituents of the extract, six sesquiterpene lactones (cynaropicrin, grosheimin, 11β,13-dihydrocynaropicrin, 3β...

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Veröffentlicht in:	Journal of natural medicines 2021-03, Vol.75 (2), p.381-392
Hauptverfasser:	Matsumoto, Tomoko, Nakashima, Souichi, Nakamura, Seikou, Hattori, Yasunao, Ando, Tomoshige, Matsuda, Hisashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Biomedical and Life Sciences Biomedicine Butyrolactone Carbonyl compounds Complementary & Alternative Medicine Cynara scolymus Cynara scolymus - chemistry Cytotoxicity Flowers & plants Lactones Lactones - chemistry Lactones - pharmacology Lactones - therapeutic use Lipopolysaccharides Medicinal Chemistry Mice Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Original Paper Pharmacology/Toxicology Pharmacy Phytochemicals Plant Leaves - chemistry Plant Sciences RAW 264.7 Cells - metabolism Sesquiterpene lactones Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal transduction Translocase Tubulin
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