Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies
Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective antiviral activities of natural products have been proved in different studies. In this review, regarding the effective...
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| Veröffentlicht in: | Phytotherapy research 2021-02, Vol.35 (2), p.864-876 |
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| description | Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective antiviral activities of natural products have been proved in different studies. In this review, regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID‐19 treatment are suggested. An extensive search in Google Scholar, Science Direct, PubMed, ISI, and Scopus was done with search words include coronavirus, COVID‐19, SARS, MERS, natural product, herb, plant, and extract. The consumption of herbal medicine such as Allium sativum, Camellia sinensis, Zingiber officinale, Nigella sativa, Echinacea spp. Hypericum perforatum, and Glycyrrhiza glabra, Scutellaria baicalensis can improve the immune response. It seems that different types of terpenoids have promising effects in viral replication inhibition and could be introduced for future studies. Additionally, some alkaloid structures such as homoharringtonine, lycorine, and emetine have strong anti‐coronavirus effects. Natural products can inhibit different coronavirus targets such as S protein (emodin, baicalin) and viral enzymes replication such as 3CLpro (Iguesterin), PLpro (Cryptotanshinone), helicase (Silvestrol), and RdRp (Sotetsuflavone). Based on previous studies, natural products can be introduced as preventive and therapeutic agents in the fight against coronavirus. |
| doi_str_mv | 10.1002/ptr.6873 |
| format | Article |
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The effective antiviral activities of natural products have been proved in different studies. In this review, regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID‐19 treatment are suggested. An extensive search in Google Scholar, Science Direct, PubMed, ISI, and Scopus was done with search words include coronavirus, COVID‐19, SARS, MERS, natural product, herb, plant, and extract. The consumption of herbal medicine such as Allium sativum, Camellia sinensis, Zingiber officinale, Nigella sativa, Echinacea spp. Hypericum perforatum, and Glycyrrhiza glabra, Scutellaria baicalensis can improve the immune response. It seems that different types of terpenoids have promising effects in viral replication inhibition and could be introduced for future studies. Additionally, some alkaloid structures such as homoharringtonine, lycorine, and emetine have strong anti‐coronavirus effects. Natural products can inhibit different coronavirus targets such as S protein (emodin, baicalin) and viral enzymes replication such as 3CLpro (Iguesterin), PLpro (Cryptotanshinone), helicase (Silvestrol), and RdRp (Sotetsuflavone). Based on previous studies, natural products can be introduced as preventive and therapeutic agents in the fight against coronavirus.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.6873</identifier><identifier>PMID: 32985017</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>3CLpro inhibitors ; ACE2 ; Amaryllidaceae Alkaloids - therapeutic use ; Antiviral Agents - classification ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Baicalin ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Chemical compounds ; Chemoprevention - methods ; Coronaviridae ; coronavirus ; Coronavirus - classification ; Coronavirus - drug effects ; Coronavirus Infections - drug therapy ; Coronavirus Infections - epidemiology ; Coronaviruses ; COVID-19 ; COVID-19 - drug therapy ; COVID-19 - epidemiology ; Cryptotanshinone ; DNA helicase ; Emetine ; Emodin ; Ginger ; Herbal medicine ; Humans ; Immune response ; Infections ; Medicinal plants ; Natural products ; Pharmacology ; Phenanthridines - therapeutic use ; Phytotherapy - methods ; Plant extracts ; Plant Extracts - therapeutic use ; PLpro inhibitors ; Replication ; SARS-CoV-2 - drug effects ; Search engines ; Terpenes ; Therapies, Investigational - methods ; Viral diseases ; Virus Replication - drug effects</subject><ispartof>Phytotherapy research, 2021-02, Vol.35 (2), p.864-876</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2983-74926359395a27e0402ffdf1f38644e63e73d2ebf2c50869b716089472eef9383</citedby><cites>FETCH-LOGICAL-c2983-74926359395a27e0402ffdf1f38644e63e73d2ebf2c50869b716089472eef9383</cites><orcidid>0000-0001-8172-2264 ; 0000-0002-3483-851X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.6873$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.6873$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32985017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boozari, Motahareh</creatorcontrib><creatorcontrib>Hosseinzadeh, Hossein</creatorcontrib><title>Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective antiviral activities of natural products have been proved in different studies. In this review, regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID‐19 treatment are suggested. An extensive search in Google Scholar, Science Direct, PubMed, ISI, and Scopus was done with search words include coronavirus, COVID‐19, SARS, MERS, natural product, herb, plant, and extract. The consumption of herbal medicine such as Allium sativum, Camellia sinensis, Zingiber officinale, Nigella sativa, Echinacea spp. Hypericum perforatum, and Glycyrrhiza glabra, Scutellaria baicalensis can improve the immune response. It seems that different types of terpenoids have promising effects in viral replication inhibition and could be introduced for future studies. Additionally, some alkaloid structures such as homoharringtonine, lycorine, and emetine have strong anti‐coronavirus effects. Natural products can inhibit different coronavirus targets such as S protein (emodin, baicalin) and viral enzymes replication such as 3CLpro (Iguesterin), PLpro (Cryptotanshinone), helicase (Silvestrol), and RdRp (Sotetsuflavone). Based on previous studies, natural products can be introduced as preventive and therapeutic agents in the fight against coronavirus.</description><subject>3CLpro inhibitors</subject><subject>ACE2</subject><subject>Amaryllidaceae Alkaloids - therapeutic use</subject><subject>Antiviral Agents - classification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Baicalin</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Chemical compounds</subject><subject>Chemoprevention - methods</subject><subject>Coronaviridae</subject><subject>coronavirus</subject><subject>Coronavirus - classification</subject><subject>Coronavirus - drug effects</subject><subject>Coronavirus Infections - drug therapy</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - drug therapy</subject><subject>COVID-19 - epidemiology</subject><subject>Cryptotanshinone</subject><subject>DNA helicase</subject><subject>Emetine</subject><subject>Emodin</subject><subject>Ginger</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infections</subject><subject>Medicinal plants</subject><subject>Natural products</subject><subject>Pharmacology</subject><subject>Phenanthridines - therapeutic use</subject><subject>Phytotherapy - methods</subject><subject>Plant extracts</subject><subject>Plant Extracts - therapeutic use</subject><subject>PLpro inhibitors</subject><subject>Replication</subject><subject>SARS-CoV-2 - drug effects</subject><subject>Search engines</subject><subject>Terpenes</subject><subject>Therapies, Investigational - methods</subject><subject>Viral diseases</subject><subject>Virus Replication - drug effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1KAzEQx4MoWj_AJ5CAFy-rk2R3szlK_QSxIirelnR3IlvaTU2yLb35CD6jT2LaqjdPE4bf_GbyJ-SQwSkD4GfT4E7zQooN0mOgVMIyKTZJD1TGkpQVrztk1_sRACgO6TbZEVwVGTDZI_N7HTqnx3TqbN1VwVNjHe0PXm4vvj4-mYp9nGEbGttS3dY0ONRhEhvU4Zt2ddO-0WBXVGM7TyvrbKtnjYvvpjVYLSf9arS1MxxTH7q6Qb9Ptoweezz4qXvk-eryqX-T3A2ub_vnd0kVTxSJTBXPRaaEyjSXCClwY2rDjCjyNMVcoBQ1x6HhVQZFroaS5VCoVHJEo0Qh9sjx2hv_996hD-XIdq6NK0se3VkugUGkTtZU5az3Dk05dc1Eu0XJoFwmXMaEy2XCET36EXbDCdZ_4G-kEUjWwLwZ4-JfUfnw9LgSfgMt3Yai</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Boozari, Motahareh</creator><creator>Hosseinzadeh, Hossein</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-8172-2264</orcidid><orcidid>https://orcid.org/0000-0002-3483-851X</orcidid></search><sort><creationdate>202102</creationdate><title>Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies</title><author>Boozari, Motahareh ; Hosseinzadeh, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2983-74926359395a27e0402ffdf1f38644e63e73d2ebf2c50869b716089472eef9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3CLpro inhibitors</topic><topic>ACE2</topic><topic>Amaryllidaceae Alkaloids - therapeutic use</topic><topic>Antiviral Agents - classification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Baicalin</topic><topic>Biological Products - pharmacology</topic><topic>Biological Products - therapeutic use</topic><topic>Chemical compounds</topic><topic>Chemoprevention - methods</topic><topic>Coronaviridae</topic><topic>coronavirus</topic><topic>Coronavirus - classification</topic><topic>Coronavirus - drug effects</topic><topic>Coronavirus Infections - drug therapy</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - drug therapy</topic><topic>COVID-19 - epidemiology</topic><topic>Cryptotanshinone</topic><topic>DNA helicase</topic><topic>Emetine</topic><topic>Emodin</topic><topic>Ginger</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infections</topic><topic>Medicinal plants</topic><topic>Natural products</topic><topic>Pharmacology</topic><topic>Phenanthridines - therapeutic use</topic><topic>Phytotherapy - methods</topic><topic>Plant extracts</topic><topic>Plant Extracts - therapeutic use</topic><topic>PLpro inhibitors</topic><topic>Replication</topic><topic>SARS-CoV-2 - drug effects</topic><topic>Search engines</topic><topic>Terpenes</topic><topic>Therapies, Investigational - methods</topic><topic>Viral diseases</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boozari, Motahareh</creatorcontrib><creatorcontrib>Hosseinzadeh, Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boozari, Motahareh</au><au>Hosseinzadeh, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2021-02</date><risdate>2021</risdate><volume>35</volume><issue>2</issue><spage>864</spage><epage>876</epage><pages>864-876</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Recently, the novel life‐threatening coronavirus infection (COVID‐19) was reported at the end of 2019 in Wuhan, China, and spread throughout the world in little time. The effective antiviral activities of natural products have been proved in different studies. In this review, regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID‐19 treatment are suggested. An extensive search in Google Scholar, Science Direct, PubMed, ISI, and Scopus was done with search words include coronavirus, COVID‐19, SARS, MERS, natural product, herb, plant, and extract. The consumption of herbal medicine such as Allium sativum, Camellia sinensis, Zingiber officinale, Nigella sativa, Echinacea spp. Hypericum perforatum, and Glycyrrhiza glabra, Scutellaria baicalensis can improve the immune response. It seems that different types of terpenoids have promising effects in viral replication inhibition and could be introduced for future studies. Additionally, some alkaloid structures such as homoharringtonine, lycorine, and emetine have strong anti‐coronavirus effects. Natural products can inhibit different coronavirus targets such as S protein (emodin, baicalin) and viral enzymes replication such as 3CLpro (Iguesterin), PLpro (Cryptotanshinone), helicase (Silvestrol), and RdRp (Sotetsuflavone). Based on previous studies, natural products can be introduced as preventive and therapeutic agents in the fight against coronavirus.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>32985017</pmid><doi>10.1002/ptr.6873</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8172-2264</orcidid><orcidid>https://orcid.org/0000-0002-3483-851X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3CLpro inhibitors ACE2 Amaryllidaceae Alkaloids - therapeutic use Antiviral Agents - classification Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Baicalin Biological Products - pharmacology Biological Products - therapeutic use Chemical compounds Chemoprevention - methods Coronaviridae coronavirus Coronavirus - classification Coronavirus - drug effects Coronavirus Infections - drug therapy Coronavirus Infections - epidemiology Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - epidemiology Cryptotanshinone DNA helicase Emetine Emodin Ginger Herbal medicine Humans Immune response Infections Medicinal plants Natural products Pharmacology Phenanthridines - therapeutic use Phytotherapy - methods Plant extracts Plant Extracts - therapeutic use PLpro inhibitors Replication SARS-CoV-2 - drug effects Search engines Terpenes Therapies, Investigational - methods Viral diseases Virus Replication - drug effects |
| title | Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies |
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