Evaluation of carcinogenic activities and sperm abnormalities of Gram-negative bacterial metabolites isolated from cancer patients after subcutaneous injection in albino rats
Microbial pathogens drive tumorigenesis in 20% of cancer cases, so the present study is aimed to evaluate the carcinogenic activities, sperm abnormalities and other dangerous effects of the subcutaneous injection of extracts obtained from various clinical Gram-negative bacteria derived from cancer p...
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| Veröffentlicht in: | Antonie van Leeuwenhoek 2021-03, Vol.114 (3), p.287-302 |
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| creator | El-Gendy, Mervat Morsy Abbas Ahmed Abdel-Wahhab, Khaled G. Hassan, Nabila S. El-Bondkly, Esraa Ahmed Farghaly, Ayman A. Ali, Hanan F. Ali, Sanaa A. El-Bondkly, Ahmed M. A. |
| description | Microbial pathogens drive tumorigenesis in 20% of cancer cases, so the present study is aimed to evaluate the carcinogenic activities, sperm abnormalities and other dangerous effects of the subcutaneous injection of extracts obtained from various clinical Gram-negative bacteria derived from cancer patients using albino rats. We isolated, identified and extracted of their secondary metabolites of carbapenem resistant Gram-negative bacteria derived from cancer patients. Various methods have been used to determine hepatotoxicity, nephrotoxicity, tumorigenesis, inflammatory and sperm abnormalities in the albino rats injected with extracts. In comparison with the normal animals group, all extracts induced hepatotoxicity which was evidenced by the significant elevation in the activity of the serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and alkaline phosphatase; also, nephrotoxicity that was indicated through the marked increase in the serum urea and creatinine levels; tumorigenesis was achieved from the sharp elevation in serum levels of alpha fetoprotein, carcinoembryonic antigen and lactate dehydrogenase values as tumor markers; as well as severe inflammatory characteristics were monitored from the marked raise of tumor necrosis factor alpha and interleukin-1beta. Furthermore, the proportion of micronuclei in polychromatic erythrocytes and sperm abnormalities were statistically significant in all groups compared to control group. Various kinds of head abnormalities and coiled tail were noted. Histopathological examination of hepatic tissue came in line with the biochemical and cytological findings. It could conclude that the extracts of
Serratia
sp. Esraa 1,
Stenotrophomonas
sp. Esraa 2,
Acinetobacter
sp. Esraa 3,
Escherichia
sp. Esraa 4 and
Pseudomonas
sp. Esraa 5 were able to initiate cytotoxicity and tumorigenesis in rats. |
| doi_str_mv | 10.1007/s10482-021-01522-w |
| format | Article |
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Serratia
sp. Esraa 1,
Stenotrophomonas
sp. Esraa 2,
Acinetobacter
sp. Esraa 3,
Escherichia
sp. Esraa 4 and
Pseudomonas
sp. Esraa 5 were able to initiate cytotoxicity and tumorigenesis in rats.</description><identifier>ISSN: 0003-6072</identifier><identifier>EISSN: 1572-9699</identifier><identifier>DOI: 10.1007/s10482-021-01522-w</identifier><identifier>PMID: 33559865</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abnormalities ; Alanine ; Alanine transaminase ; Alkaline phosphatase ; Antigens ; Aspartate aminotransferase ; Bacteria ; Biomedical and Life Sciences ; Cancer ; Carcinoembryonic antigen ; Carcinogens ; Creatinine ; Cytotoxicity ; Erythrocytes ; Evaluation ; Gram-negative bacteria ; Hepatotoxicity ; Inflammation ; Injection ; Interleukins ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Life Sciences ; Medical Microbiology ; Metabolites ; Microbiology ; Micronuclei ; Microorganisms ; Original Paper ; Phospholipids ; Plant Sciences ; Secondary metabolites ; Serum levels ; Soil Science & Conservation ; Sperm ; Statistical analysis ; Toxicity ; Tumor markers ; Tumor necrosis factor-α ; Tumorigenesis ; Urea</subject><ispartof>Antonie van Leeuwenhoek, 2021-03, Vol.114 (3), p.287-302</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5f6d1b06473c9c7c95346aef88d27769cc3046275912d11f4c7d1e5875179d283</citedby><cites>FETCH-LOGICAL-c375t-5f6d1b06473c9c7c95346aef88d27769cc3046275912d11f4c7d1e5875179d283</cites><orcidid>0000-0002-0680-3205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10482-021-01522-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10482-021-01522-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33559865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Gendy, Mervat Morsy Abbas Ahmed</creatorcontrib><creatorcontrib>Abdel-Wahhab, Khaled G.</creatorcontrib><creatorcontrib>Hassan, Nabila S.</creatorcontrib><creatorcontrib>El-Bondkly, Esraa Ahmed</creatorcontrib><creatorcontrib>Farghaly, Ayman A.</creatorcontrib><creatorcontrib>Ali, Hanan F.</creatorcontrib><creatorcontrib>Ali, Sanaa A.</creatorcontrib><creatorcontrib>El-Bondkly, Ahmed M. A.</creatorcontrib><title>Evaluation of carcinogenic activities and sperm abnormalities of Gram-negative bacterial metabolites isolated from cancer patients after subcutaneous injection in albino rats</title><title>Antonie van Leeuwenhoek</title><addtitle>Antonie van Leeuwenhoek</addtitle><addtitle>Antonie Van Leeuwenhoek</addtitle><description>Microbial pathogens drive tumorigenesis in 20% of cancer cases, so the present study is aimed to evaluate the carcinogenic activities, sperm abnormalities and other dangerous effects of the subcutaneous injection of extracts obtained from various clinical Gram-negative bacteria derived from cancer patients using albino rats. We isolated, identified and extracted of their secondary metabolites of carbapenem resistant Gram-negative bacteria derived from cancer patients. Various methods have been used to determine hepatotoxicity, nephrotoxicity, tumorigenesis, inflammatory and sperm abnormalities in the albino rats injected with extracts. In comparison with the normal animals group, all extracts induced hepatotoxicity which was evidenced by the significant elevation in the activity of the serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and alkaline phosphatase; also, nephrotoxicity that was indicated through the marked increase in the serum urea and creatinine levels; tumorigenesis was achieved from the sharp elevation in serum levels of alpha fetoprotein, carcinoembryonic antigen and lactate dehydrogenase values as tumor markers; as well as severe inflammatory characteristics were monitored from the marked raise of tumor necrosis factor alpha and interleukin-1beta. Furthermore, the proportion of micronuclei in polychromatic erythrocytes and sperm abnormalities were statistically significant in all groups compared to control group. Various kinds of head abnormalities and coiled tail were noted. Histopathological examination of hepatic tissue came in line with the biochemical and cytological findings. It could conclude that the extracts of
Serratia
sp. Esraa 1,
Stenotrophomonas
sp. Esraa 2,
Acinetobacter
sp. Esraa 3,
Escherichia
sp. Esraa 4 and
Pseudomonas
sp. Esraa 5 were able to initiate cytotoxicity and tumorigenesis in rats.</description><subject>Abnormalities</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Antigens</subject><subject>Aspartate aminotransferase</subject><subject>Bacteria</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Carcinoembryonic antigen</subject><subject>Carcinogens</subject><subject>Creatinine</subject><subject>Cytotoxicity</subject><subject>Erythrocytes</subject><subject>Evaluation</subject><subject>Gram-negative bacteria</subject><subject>Hepatotoxicity</subject><subject>Inflammation</subject><subject>Injection</subject><subject>Interleukins</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Metabolites</subject><subject>Microbiology</subject><subject>Micronuclei</subject><subject>Microorganisms</subject><subject>Original Paper</subject><subject>Phospholipids</subject><subject>Plant Sciences</subject><subject>Secondary metabolites</subject><subject>Serum levels</subject><subject>Soil Science & Conservation</subject><subject>Sperm</subject><subject>Statistical analysis</subject><subject>Toxicity</subject><subject>Tumor markers</subject><subject>Tumor necrosis factor-α</subject><subject>Tumorigenesis</subject><subject>Urea</subject><issn>0003-6072</issn><issn>1572-9699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU1vFSEUhonRtLe1f8CFIXFN5WOAYWma2jZp4kbXhGHO3HAzA1dgbuOf8jeKnao7VwR4nvec5EXoHaPXjFL9sTDa9ZxQzghlknPy9ArtmNScGGXMa7SjlAqiqObn6KKUQ7sa1eszdC6ElKZXcod-3p7cvLoaUsRpwt5lH2LaQwweO1_DKdQABbs44nKEvGA3xJQXN2_vTbnLbiER9i3jBHhoEuTgZrxAdUNqXMNCSbOrMOIpp6UNiR4yPjYDYm3hU1NwWQe_VhchrU2IB_DPS4WI3Ty0nXB2tbxFbyY3F7h6OS_Rt8-3X2_uyeOXu4ebT4_ECy0rkZMa2UBVp4U3XnsjRaccTH0_cq2V8V7QTnEtDeMjY1Pn9chA9loybUbei0v0Ycs95vR9hVLtIa05tpGWd4Z3mlNjGsU3yudUSobJHnNYXP5hGbW_K7JbRbZVZJ8rsk9Nev8SvQ4LjH-VP500QGxAaV9xD_nf7P_E_gLCj6Dh</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>El-Gendy, Mervat Morsy Abbas Ahmed</creator><creator>Abdel-Wahhab, Khaled G.</creator><creator>Hassan, Nabila S.</creator><creator>El-Bondkly, Esraa Ahmed</creator><creator>Farghaly, Ayman A.</creator><creator>Ali, Hanan F.</creator><creator>Ali, Sanaa A.</creator><creator>El-Bondkly, Ahmed M. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of carcinogenic activities and sperm abnormalities of Gram-negative bacterial metabolites isolated from cancer patients after subcutaneous injection in albino rats</atitle><jtitle>Antonie van Leeuwenhoek</jtitle><stitle>Antonie van Leeuwenhoek</stitle><addtitle>Antonie Van Leeuwenhoek</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>114</volume><issue>3</issue><spage>287</spage><epage>302</epage><pages>287-302</pages><issn>0003-6072</issn><eissn>1572-9699</eissn><abstract>Microbial pathogens drive tumorigenesis in 20% of cancer cases, so the present study is aimed to evaluate the carcinogenic activities, sperm abnormalities and other dangerous effects of the subcutaneous injection of extracts obtained from various clinical Gram-negative bacteria derived from cancer patients using albino rats. We isolated, identified and extracted of their secondary metabolites of carbapenem resistant Gram-negative bacteria derived from cancer patients. Various methods have been used to determine hepatotoxicity, nephrotoxicity, tumorigenesis, inflammatory and sperm abnormalities in the albino rats injected with extracts. In comparison with the normal animals group, all extracts induced hepatotoxicity which was evidenced by the significant elevation in the activity of the serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and alkaline phosphatase; also, nephrotoxicity that was indicated through the marked increase in the serum urea and creatinine levels; tumorigenesis was achieved from the sharp elevation in serum levels of alpha fetoprotein, carcinoembryonic antigen and lactate dehydrogenase values as tumor markers; as well as severe inflammatory characteristics were monitored from the marked raise of tumor necrosis factor alpha and interleukin-1beta. Furthermore, the proportion of micronuclei in polychromatic erythrocytes and sperm abnormalities were statistically significant in all groups compared to control group. Various kinds of head abnormalities and coiled tail were noted. Histopathological examination of hepatic tissue came in line with the biochemical and cytological findings. It could conclude that the extracts of
Serratia
sp. Esraa 1,
Stenotrophomonas
sp. Esraa 2,
Acinetobacter
sp. Esraa 3,
Escherichia
sp. Esraa 4 and
Pseudomonas
sp. Esraa 5 were able to initiate cytotoxicity and tumorigenesis in rats.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33559865</pmid><doi>10.1007/s10482-021-01522-w</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-0680-3205</orcidid></addata></record> |
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| ispartof | Antonie van Leeuwenhoek, 2021-03, Vol.114 (3), p.287-302 |
| issn | 0003-6072 1572-9699 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Abnormalities Alanine Alanine transaminase Alkaline phosphatase Antigens Aspartate aminotransferase Bacteria Biomedical and Life Sciences Cancer Carcinoembryonic antigen Carcinogens Creatinine Cytotoxicity Erythrocytes Evaluation Gram-negative bacteria Hepatotoxicity Inflammation Injection Interleukins L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Life Sciences Medical Microbiology Metabolites Microbiology Micronuclei Microorganisms Original Paper Phospholipids Plant Sciences Secondary metabolites Serum levels Soil Science & Conservation Sperm Statistical analysis Toxicity Tumor markers Tumor necrosis factor-α Tumorigenesis Urea |
| title | Evaluation of carcinogenic activities and sperm abnormalities of Gram-negative bacterial metabolites isolated from cancer patients after subcutaneous injection in albino rats |
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