A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response 1 . Here we describe the development of a candidate vaccine (YF-S0) for severe acute resp...

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Veröffentlicht in:	Nature (London) 2021-02, Vol.590 (7845), p.320-325
Hauptverfasser:	Sanchez-Felipe, Lorena, Vercruysse, Thomas, Sharma, Sapna, Ma, Ji, Lemmens, Viktor, Van Looveren, Dominique, Arkalagud Javarappa, Mahadesh Prasad, Boudewijns, Robbert, Malengier-Devlies, Bert, Liesenborghs, Laurens, Kaptein, Suzanne J. F., De Keyzer, Carolien, Bervoets, Lindsey, Debaveye, Sarah, Rasulova, Madina, Seldeslachts, Laura, Li, Li-Hsin, Jansen, Sander, Yakass, Michael Bright, Verstrepen, Babs E., Böszörményi, Kinga P., Kiemenyi-Kayere, Gwendoline, van Driel, Nikki, Quaye, Osbourne, Zhang, Xin, ter Horst, Sebastiaan, Mishra, Niraj, Deboutte, Ward, Matthijnssens, Jelle, Coelmont, Lotte, Vandermeulen, Corinne, Heylen, Elisabeth, Vergote, Valentijn, Schols, Dominique, Wang, Zhongde, Bogers, Willy, Kuiken, Thijs, Verschoor, Ernst, Cawthorne, Christopher, Van Laere, Koen, Opdenakker, Ghislain, Vande Velde, Greetje, Weynand, Birgit, Teuwen, Dirk E., Matthys, Patrick, Neyts, Johan, Jan Thibaut, Hendrik, Dallmeier, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/21 13/31 13/44 13/51 14 14/19 14/63 38/23 38/39 59 631/250/590/1867 631/326/596/4130 692/699/255/2514 Animal models Animals Antibodies Antigens Confidence intervals Coronaviridae Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - adverse effects COVID-19 Vaccines - genetics COVID-19 Vaccines - immunology Cricetinae Disease Models, Animal Emergency response Female Fever Genetic Vectors - genetics Glycosylation Hamsters Health aspects Humanities and Social Sciences Humoral immunity Immune response Immune response (cell-mediated) Immune system Immunity Immunogenicity Infections Lung diseases Lungs Macaca fascicularis - genetics Macaca fascicularis - immunology Macaca fascicularis - virology Male Mesocricetus - genetics Mesocricetus - immunology Mesocricetus - virology Mice multidisciplinary Pandemics Respiratory diseases Safety SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vector-borne diseases Viral antibodies Viral diseases Viral infections Viruses Yellow Fever Vaccine - genetics
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