Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery
Hierarchical self‐assembly (HAS) is a powerful approach to create supramolecular nanostructures for biomedical applications. This potency, however, is generally challenged by the difficulty of controlling the HAS of biomacromolecules and the functionality of resulted HAS nanostructures. Herein, we r...
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| Veröffentlicht in: | Angewandte Chemie 2021-03, Vol.133 (10), p.5489-5495 |
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| creator | Liu, Ji Luo, Tianli Xue, Yifei Mao, Lanqun Stang, Peter J. Wang, Ming |
| description | Hierarchical self‐assembly (HAS) is a powerful approach to create supramolecular nanostructures for biomedical applications. This potency, however, is generally challenged by the difficulty of controlling the HAS of biomacromolecules and the functionality of resulted HAS nanostructures. Herein, we report a modular approach for controlling the HAS of discrete metal–organic cages (MOC) into supramolecular nanoparticles, and its potential for intracellular protein delivery and cell‐fate specification. The hierarchical coordination‐driven self‐assembly of adamantane‐functionalized M12L24 MOC (Ada‐MOC) and the host–guest interaction of Ada‐MOC with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) afford supramolecular nanoparticles in a controllable manner. HAS maintains high efficiency and orthogonality in the presence of protein, enabling the encapsulation of protein into the nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.
Self‐assembly of Ada‐MOC and host–guest interaction with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) affords supramolecular nanoparticles. Hierarchical self‐assembly of Ada‐MOC and PEI‐βCD maintains high efficiency and orthogonality in the presence of protein, enabling protein encapsulation into nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing. |
| doi_str_mv | 10.1002/ange.202013904 |
| format | Article |
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Self‐assembly of Ada‐MOC and host–guest interaction with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) affords supramolecular nanoparticles. Hierarchical self‐assembly of Ada‐MOC and PEI‐βCD maintains high efficiency and orthogonality in the presence of protein, enabling protein encapsulation into nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.202013904</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Assembly ; Biomedical materials ; Cages ; Chemistry ; CRISPR ; CRISPR/Cas9 genome editing ; Cyclodextrins ; Genomes ; hierarchical self-assembly ; Intracellular ; Nanoparticles ; Nanostructure ; Orthogonality ; Polyethyleneimine ; protein delivery ; Proteins ; Stability ; supramolecular nanoparticles ; β-Cyclodextrin</subject><ispartof>Angewandte Chemie, 2021-03, Vol.133 (10), p.5489-5495</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1624-ae691d644cda80257324da7b2bd6632dba66f7abe0cb2ce3983d7c4ae70c64413</citedby><cites>FETCH-LOGICAL-c1624-ae691d644cda80257324da7b2bd6632dba66f7abe0cb2ce3983d7c4ae70c64413</cites><orcidid>0000-0002-2783-9426</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fange.202013904$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fange.202013904$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Liu, Ji</creatorcontrib><creatorcontrib>Luo, Tianli</creatorcontrib><creatorcontrib>Xue, Yifei</creatorcontrib><creatorcontrib>Mao, Lanqun</creatorcontrib><creatorcontrib>Stang, Peter J.</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><title>Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery</title><title>Angewandte Chemie</title><description>Hierarchical self‐assembly (HAS) is a powerful approach to create supramolecular nanostructures for biomedical applications. This potency, however, is generally challenged by the difficulty of controlling the HAS of biomacromolecules and the functionality of resulted HAS nanostructures. Herein, we report a modular approach for controlling the HAS of discrete metal–organic cages (MOC) into supramolecular nanoparticles, and its potential for intracellular protein delivery and cell‐fate specification. The hierarchical coordination‐driven self‐assembly of adamantane‐functionalized M12L24 MOC (Ada‐MOC) and the host–guest interaction of Ada‐MOC with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) afford supramolecular nanoparticles in a controllable manner. HAS maintains high efficiency and orthogonality in the presence of protein, enabling the encapsulation of protein into the nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.
Self‐assembly of Ada‐MOC and host–guest interaction with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) affords supramolecular nanoparticles. Hierarchical self‐assembly of Ada‐MOC and PEI‐βCD maintains high efficiency and orthogonality in the presence of protein, enabling protein encapsulation into nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.</description><subject>Assembly</subject><subject>Biomedical materials</subject><subject>Cages</subject><subject>Chemistry</subject><subject>CRISPR</subject><subject>CRISPR/Cas9 genome editing</subject><subject>Cyclodextrins</subject><subject>Genomes</subject><subject>hierarchical self-assembly</subject><subject>Intracellular</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Orthogonality</subject><subject>Polyethyleneimine</subject><subject>protein delivery</subject><subject>Proteins</subject><subject>Stability</subject><subject>supramolecular nanoparticles</subject><subject>β-Cyclodextrin</subject><issn>0044-8249</issn><issn>1521-3757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLxDAQgIMouD6ungOeuyZpNm2Psj7BF6jnMk2nayTbrJOusjfBPyD4D_0ldl3Ro6c5zPfNwMfYnhRDKYQ6gHaCQyWUkGkh9BobyJGSSZqNsnU2EELrJFe62GRbMT4KIYzKigF7O3NIQPbBWfD8Fn3z-foOMeK08gseGn7koiXskF9iB_7z9eOaJtA6y8cwwchd2wV-O58RTINHO_dA_AraMAPqnPU90QTi521HYNH77_0NhQ5dy4_Qu2ekxQ7baMBH3P2Z2-z-5PhufJZcXJ-ejw8vEiuN0gmgKWRttLY15EKNslTpGrJKVbUxqaorMKbJoEJhK2UxLfK0zqwGzITtLZlus_3V3RmFpznGrnwMc2r7l2UfRuYjlZslNVxRlkKMhE05IzcFWpRSlMvQ5TJ0-Ru6F4qV8OI8Lv6hy8Or0-M_9wv1W4bA</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Liu, Ji</creator><creator>Luo, Tianli</creator><creator>Xue, Yifei</creator><creator>Mao, Lanqun</creator><creator>Stang, Peter J.</creator><creator>Wang, Ming</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-2783-9426</orcidid></search><sort><creationdate>20210301</creationdate><title>Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery</title><author>Liu, Ji ; Luo, Tianli ; Xue, Yifei ; Mao, Lanqun ; Stang, Peter J. ; Wang, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1624-ae691d644cda80257324da7b2bd6632dba66f7abe0cb2ce3983d7c4ae70c64413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Assembly</topic><topic>Biomedical materials</topic><topic>Cages</topic><topic>Chemistry</topic><topic>CRISPR</topic><topic>CRISPR/Cas9 genome editing</topic><topic>Cyclodextrins</topic><topic>Genomes</topic><topic>hierarchical self-assembly</topic><topic>Intracellular</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Orthogonality</topic><topic>Polyethyleneimine</topic><topic>protein delivery</topic><topic>Proteins</topic><topic>Stability</topic><topic>supramolecular nanoparticles</topic><topic>β-Cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ji</creatorcontrib><creatorcontrib>Luo, Tianli</creatorcontrib><creatorcontrib>Xue, Yifei</creatorcontrib><creatorcontrib>Mao, Lanqun</creatorcontrib><creatorcontrib>Stang, Peter J.</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Angewandte Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ji</au><au>Luo, Tianli</au><au>Xue, Yifei</au><au>Mao, Lanqun</au><au>Stang, Peter J.</au><au>Wang, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery</atitle><jtitle>Angewandte Chemie</jtitle><date>2021-03-01</date><risdate>2021</risdate><volume>133</volume><issue>10</issue><spage>5489</spage><epage>5495</epage><pages>5489-5495</pages><issn>0044-8249</issn><eissn>1521-3757</eissn><abstract>Hierarchical self‐assembly (HAS) is a powerful approach to create supramolecular nanostructures for biomedical applications. This potency, however, is generally challenged by the difficulty of controlling the HAS of biomacromolecules and the functionality of resulted HAS nanostructures. Herein, we report a modular approach for controlling the HAS of discrete metal–organic cages (MOC) into supramolecular nanoparticles, and its potential for intracellular protein delivery and cell‐fate specification. The hierarchical coordination‐driven self‐assembly of adamantane‐functionalized M12L24 MOC (Ada‐MOC) and the host–guest interaction of Ada‐MOC with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) afford supramolecular nanoparticles in a controllable manner. HAS maintains high efficiency and orthogonality in the presence of protein, enabling the encapsulation of protein into the nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.
Self‐assembly of Ada‐MOC and host–guest interaction with β‐cyclodextrin‐conjugated polyethylenimine (PEI‐βCD) affords supramolecular nanoparticles. Hierarchical self‐assembly of Ada‐MOC and PEI‐βCD maintains high efficiency and orthogonality in the presence of protein, enabling protein encapsulation into nanoparticles for intracellular protein delivery for therapeutic application and CRISPR/Cas9 genome editing.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ange.202013904</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2783-9426</orcidid></addata></record> |
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| subjects | Assembly Biomedical materials Cages Chemistry CRISPR CRISPR/Cas9 genome editing Cyclodextrins Genomes hierarchical self-assembly Intracellular Nanoparticles Nanostructure Orthogonality Polyethyleneimine protein delivery Proteins Stability supramolecular nanoparticles β-Cyclodextrin |
| title | Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery |
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