Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods

Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active site and either exosite I or exosite II. Herein, w...

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Veröffentlicht in:Angewandte Chemie International Edition 2021-03, Vol.60 (10), p.5348-5356
Hauptverfasser: Agten, Stijn M., Watson, Emma E., Ripoll‐Rozada, Jorge, Dowman, Luke J., Wu, Mike C. L., Alwis, Imala, Jackson, Shaun P., Pereira, Pedro José Barbosa, Payne, Richard J.
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Sprache:eng
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