Brassica oleracea var. capitata L. Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity
Brassica oleracea var. capitata L. (white cabbage) is a valuable vegetable with diverse nutraceutical benefit. Present study aimed to investigate the preventive effects of B. oleracea extract (BOE) standardized by vitamin U on indomethacin (IND)-induced acute gastric injury in Sprague-Dawley rats. P...
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| Veröffentlicht in: | Processes 2021-02, Vol.9 (2), p.372 |
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| creator | Ryou, Seong Hwan Cho, Il Je Choi, Beom-Rak Kim, Moon Bong Kwon, Young Sam Ku, Sae Kwang |
| description | Brassica oleracea var. capitata L. (white cabbage) is a valuable vegetable with diverse nutraceutical benefit. Present study aimed to investigate the preventive effects of B. oleracea extract (BOE) standardized by vitamin U on indomethacin (IND)-induced acute gastric injury in Sprague-Dawley rats. Pre-administration of three different doses of BOE (12.5–50 mg/kg) for 14 days significantly decreased visible ulcerative lesions in the gastric tissue. In addition, BOE alleviated IND-mediated increase in histological score with inhibiting invaded percentage of lesion and restoring mucosa thickness in peri-ulcerative region. BOE increased the gastric tissue bound to Alcian blue and inhibited the decrease in hexose, sialic acid, and collagen levels by IND, suggesting that BOE protects the gastric tissue through preserving mucus and mucosal integrity. Moreover, BOE pre-administration blocked the reduction of prostaglandin E2 and down-regulated histamine and mRNA expression related to secret gastric acid. Furthermore, BOE mitigated inflammatory responses in the gastric tissue by decreasing activity of myeloperoxidase and expression of nuclear factor-κB-dependent inflammatory genes. BOE also suppressed malondialdehyde with preventing the reduction of glutathione, superoxide dismutase, and catalase in the gastric tissue. Therefore, results from present study suggest that BOE will have a potential for preventing gastric injury. |
| doi_str_mv | 10.3390/pr9020372 |
| format | Article |
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Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB Electronic Journals Library</source><creator>Ryou, Seong Hwan ; Cho, Il Je ; Choi, Beom-Rak ; Kim, Moon Bong ; Kwon, Young Sam ; Ku, Sae Kwang</creator><creatorcontrib>Ryou, Seong Hwan ; Cho, Il Je ; Choi, Beom-Rak ; Kim, Moon Bong ; Kwon, Young Sam ; Ku, Sae Kwang</creatorcontrib><description>Brassica oleracea var. capitata L. (white cabbage) is a valuable vegetable with diverse nutraceutical benefit. Present study aimed to investigate the preventive effects of B. oleracea extract (BOE) standardized by vitamin U on indomethacin (IND)-induced acute gastric injury in Sprague-Dawley rats. Pre-administration of three different doses of BOE (12.5–50 mg/kg) for 14 days significantly decreased visible ulcerative lesions in the gastric tissue. In addition, BOE alleviated IND-mediated increase in histological score with inhibiting invaded percentage of lesion and restoring mucosa thickness in peri-ulcerative region. BOE increased the gastric tissue bound to Alcian blue and inhibited the decrease in hexose, sialic acid, and collagen levels by IND, suggesting that BOE protects the gastric tissue through preserving mucus and mucosal integrity. Moreover, BOE pre-administration blocked the reduction of prostaglandin E2 and down-regulated histamine and mRNA expression related to secret gastric acid. Furthermore, BOE mitigated inflammatory responses in the gastric tissue by decreasing activity of myeloperoxidase and expression of nuclear factor-κB-dependent inflammatory genes. BOE also suppressed malondialdehyde with preventing the reduction of glutathione, superoxide dismutase, and catalase in the gastric tissue. Therefore, results from present study suggest that BOE will have a potential for preventing gastric injury.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr9020372</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antioxidants ; Brassica ; Brassica oleracea capitata ; Catalase ; Collagen ; Functional foods & nutraceuticals ; Gastric juice ; Gene expression ; Glutathione ; Hexose ; Histamine ; Indomethacin ; Inflammation ; Injury prevention ; Malondialdehyde ; Mucosa ; Mucus ; Oxidative stress ; Peroxidase ; Prostaglandin E2 ; Superoxide dismutase ; Tumor necrosis factor-TNF ; Ulcers</subject><ispartof>Processes, 2021-02, Vol.9 (2), p.372</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity</title><title>Processes</title><description>Brassica oleracea var. capitata L. (white cabbage) is a valuable vegetable with diverse nutraceutical benefit. Present study aimed to investigate the preventive effects of B. oleracea extract (BOE) standardized by vitamin U on indomethacin (IND)-induced acute gastric injury in Sprague-Dawley rats. Pre-administration of three different doses of BOE (12.5–50 mg/kg) for 14 days significantly decreased visible ulcerative lesions in the gastric tissue. In addition, BOE alleviated IND-mediated increase in histological score with inhibiting invaded percentage of lesion and restoring mucosa thickness in peri-ulcerative region. 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Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity</title><author>Ryou, Seong Hwan ; Cho, Il Je ; Choi, Beom-Rak ; Kim, Moon Bong ; Kwon, Young Sam ; Ku, Sae Kwang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-518a16f78905ba53fb6aa84da245fa355d1ed81ed6dd0837cb55115560ddf34d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Brassica</topic><topic>Brassica oleracea capitata</topic><topic>Catalase</topic><topic>Collagen</topic><topic>Functional foods & nutraceuticals</topic><topic>Gastric juice</topic><topic>Gene expression</topic><topic>Glutathione</topic><topic>Hexose</topic><topic>Histamine</topic><topic>Indomethacin</topic><topic>Inflammation</topic><topic>Injury prevention</topic><topic>Malondialdehyde</topic><topic>Mucosa</topic><topic>Mucus</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Prostaglandin E2</topic><topic>Superoxide dismutase</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryou, Seong Hwan</creatorcontrib><creatorcontrib>Cho, Il Je</creatorcontrib><creatorcontrib>Choi, Beom-Rak</creatorcontrib><creatorcontrib>Kim, Moon Bong</creatorcontrib><creatorcontrib>Kwon, Young Sam</creatorcontrib><creatorcontrib>Ku, Sae Kwang</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Database (Proquest)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Materials Research Database</collection><collection>https://resources.nclive.org/materials</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Processes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryou, Seong Hwan</au><au>Cho, Il Je</au><au>Choi, Beom-Rak</au><au>Kim, Moon Bong</au><au>Kwon, Young Sam</au><au>Ku, Sae Kwang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brassica oleracea var. capitata L. Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity</atitle><jtitle>Processes</jtitle><date>2021-02-01</date><risdate>2021</risdate><volume>9</volume><issue>2</issue><spage>372</spage><pages>372-</pages><issn>2227-9717</issn><eissn>2227-9717</eissn><abstract>Brassica oleracea var. capitata L. (white cabbage) is a valuable vegetable with diverse nutraceutical benefit. Present study aimed to investigate the preventive effects of B. oleracea extract (BOE) standardized by vitamin U on indomethacin (IND)-induced acute gastric injury in Sprague-Dawley rats. Pre-administration of three different doses of BOE (12.5–50 mg/kg) for 14 days significantly decreased visible ulcerative lesions in the gastric tissue. In addition, BOE alleviated IND-mediated increase in histological score with inhibiting invaded percentage of lesion and restoring mucosa thickness in peri-ulcerative region. BOE increased the gastric tissue bound to Alcian blue and inhibited the decrease in hexose, sialic acid, and collagen levels by IND, suggesting that BOE protects the gastric tissue through preserving mucus and mucosal integrity. Moreover, BOE pre-administration blocked the reduction of prostaglandin E2 and down-regulated histamine and mRNA expression related to secret gastric acid. Furthermore, BOE mitigated inflammatory responses in the gastric tissue by decreasing activity of myeloperoxidase and expression of nuclear factor-κB-dependent inflammatory genes. BOE also suppressed malondialdehyde with preventing the reduction of glutathione, superoxide dismutase, and catalase in the gastric tissue. 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| subjects | Antioxidants Brassica Brassica oleracea capitata Catalase Collagen Functional foods & nutraceuticals Gastric juice Gene expression Glutathione Hexose Histamine Indomethacin Inflammation Injury prevention Malondialdehyde Mucosa Mucus Oxidative stress Peroxidase Prostaglandin E2 Superoxide dismutase Tumor necrosis factor-TNF Ulcers |
| title | Brassica oleracea var. capitata L. Alleviates Indomethacin-Induced Acute Gastric Injury by Enhancing Anti-Inflammatory and Antioxidant Activity |
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