Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

G protein-coupled receptors (GPCRs) are key regulators of information transmission between cells and organs. Despite this, we have only a limited understanding of the behavior of GPCRs in the apo state and the conformational changes upon agonist binding that lead to G protein recruitment and activat...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-04, Vol.372 (6538)
Hauptverfasser:	Josephs, Tracy M, Belousoff, Matthew J, Liang, Yi-Lynn, Piper, Sarah J, Cao, Jianjun, Garama, Daniel J, Leach, Katie, Gregory, Karen J, Christopoulos, Arthur, Hay, Debbie L, Danev, Radostin, Wootten, Denise, Sexton, Patrick M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoproteins - chemistry Apoproteins - metabolism Binding Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - chemistry Calcitonin Gene-Related Peptide - metabolism Calcitonin Receptor-Like Protein - chemistry Cell Line Cell Membrane - metabolism Cryoelectron Microscopy Destabilization Deuterium Domains Dynamic structural analysis Dynamics Electron microscopy Exchanging GTP-Binding Protein alpha Subunits, Gs - chemistry GTP-Binding Protein alpha Subunits, Gs - metabolism Hormones Humans Hydrogen Deuterium Exchange-Mass Spectrometry Immunology Information flow Information Transfer Insects Ligands Mass spectrometry Metabolism Microscopy Migraine Models, Molecular Moths Neuropeptides Peptides Physiology Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Structure, Secondary Proteins Receptor Activity-Modifying Protein 1 - chemistry Receptor Activity-Modifying Protein 1 - metabolism Receptors Receptors, Calcitonin Gene-Related Peptide - chemistry Receptors, Calcitonin Gene-Related Peptide - metabolism Recruitment Regulation Regulators Scientific imaging Spectroscopy Three dimensional analysis Transmission electron microscopy Variance analysis
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