Clinical Evaluation of IntelliPlex™ KRAS G12/13 Mutation Kit for Detection of KRAS Mutations in Codon 12 and 13: A Novel Multiplex Approach

Background Colorectal cancer (CRC) is among the most frequently occurring cancers worldwide and its incidence is forecasted to increase. Testing for KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations in colorectal tissue biopsy samples has become a crucial tool to guide therapeutic decision...

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Veröffentlicht in:	Molecular diagnosis & therapy 2019-10, Vol.23 (5), p.645-656
Hauptverfasser:	Chen, Chi-Long, Chen, Chi-Kuan, Ho, Chung-Liang, Chi, Wei-Ming, Yeh, Chien-Hsuan, Hu, Shian-Pin, Friebe, Peter, Palmer, Stuart, Huang, Chin-Shiou
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Biopsy Cancer Cancer Research Cancer therapies Codon Codons Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - therapy Confidence intervals Deoxyribonucleic acid DNA DNA Mutational Analysis - methods Epidermal growth factor FDA approval Genotypes Homology Human Genetics Humans K-Ras protein Laboratory Medicine Molecular Medicine Mutation Neoplasm Grading Neoplasm Staging Original Research Article Paraffin Paraffins Pharmacotherapy Proto-Oncogene Proteins p21(ras) - genetics Reagent Kits, Diagnostic Sarcoma Sensitivity Sensitivity and Specificity Sequence Analysis, DNA Stains & staining Tissues Tumors
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