Description of parallel and sequential configurations for concurrent therapeutic plasma exchange and continuous kidney replacement therapy in adults

Therapeutic plasma exchange (TPE) and continuous kidney replacement therapy (CKRT) are extracorporeal therapeutic procedures often implemented in management of patients. Critically ill patients may be afflicted with disease processes that require both TPE and CKRT. Performing TPE discontinuous with...

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Veröffentlicht in:Journal of clinical apheresis 2021-02, Vol.36 (1), p.211-218
Hauptverfasser: Kaushik, Manish, Liew, Zhong Hong, Sewa, Duu‐Wen, Phua, Ghee Chee, Cao, Ling, Krishnamoorthy, Thinesh Lee, Ng, Shin Yi, Lim, Amy Ee Lin, Ng, Li Choo, Koniman, Riece, Teo, Su Hooi, Tan, Han Khim
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container_end_page 218
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container_title Journal of clinical apheresis
container_volume 36
creator Kaushik, Manish
Liew, Zhong Hong
Sewa, Duu‐Wen
Phua, Ghee Chee
Cao, Ling
Krishnamoorthy, Thinesh Lee
Ng, Shin Yi
Lim, Amy Ee Lin
Ng, Li Choo
Koniman, Riece
Teo, Su Hooi
Tan, Han Khim
description Therapeutic plasma exchange (TPE) and continuous kidney replacement therapy (CKRT) are extracorporeal therapeutic procedures often implemented in management of patients. Critically ill patients may be afflicted with disease processes that require both TPE and CKRT. Performing TPE discontinuous with CKRT is technically easier, however, it disrupts CKRT and may compromise with CKRT efficiency or hemofilter life. Concurrent TPE with CKRT offers several advantages including simultaneous control of disease process and correction of electrolyte, fluid, and acid‐base disturbances that may accompany TPE. Additionally, TPE may be performed by either centrifugation method or membrane plasma separation method. The technical specifications of these methods may influence the methodology of concurrent connections. This report describes and reviews two different approaches to circuit arrangements when establishing concurrent TPE and CKRT.
doi_str_mv 10.1002/jca.21854
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subjects acute liver failure
Apheresis
concurrent
continuous kidney replacement therapy
Liver diseases
Plasma
plasma exchange
Renal replacement therapy
tandem
thrombotic thrombocytopenic purpura
title Description of parallel and sequential configurations for concurrent therapeutic plasma exchange and continuous kidney replacement therapy in adults
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