A novel target anti-interleukin-13 receptor subunit alpha-2 monoclonal antibody inhibits tumor growth and metastasis in lung cancer

•We generated a novel target anti-IL13Rα2 monoclonal antibody 15D8 through hybridoma technique.•mAb15D8 binds to a specific epitope of IL13Rα2 antigen from 57 to 71 amino acids.•mAb15D8 inhibited tumor growth and metastasis in lung cancer.•It exerts no toxic effects on major organs of mice.•This ant...

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Veröffentlicht in:	International immunopharmacology 2021-01, Vol.90, p.107155, Article 107155
Hauptverfasser:	Raza, Ghulam, Yunus, Fakhar-un-Nisa, Mangukiya, Hitesh Bhagavanbhai, Merugu, Siva Bharath, Mashausi, Dhahiri Saidi, Zeling, Wang, Negi, Hema, Zhou, Bingjie, Roy, Debmalya, Wu, Zhenghua, Li, Dawei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-IL13Rα2 monoclonal antibody Antigens Binding sites Cancer therapies Cell migration Cell proliferation Chemical compounds Cytokines Epitope Epitopes Fibronectin Interleukin 1 Interleukin 13 Lung cancer Lung metastasis mAb15D8 Medical prognosis Metastases Metastasis Monoclonal antibodies Mutagenesis Pharmacokinetics Pharmacology Receptors Survival Toxicology Tumors Xenografts Xenotransplantation
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