Implications for body weight extremes in solid organ transplantation
The pharmacokinetic profiles of medications are altered in overweight and underweight patients, but few studies have described these differences in patients with body mass index extremes. As solid organ transplant programs expand their candidate selection criteria to accommodate a growing population...
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| Veröffentlicht in: | Pharmacotherapy 2021-01, Vol.41 (1), p.44-58 |
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| container_title | Pharmacotherapy |
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| creator | Campara, Maya Lourenco, Laura M. Melaragno, Jennifer I. Kaiser, Tiffany E. |
| description | The pharmacokinetic profiles of medications are altered in overweight and underweight patients, but few studies have described these differences in patients with body mass index extremes. As solid organ transplant programs expand their candidate selection criteria to accommodate a growing population of patients with weight extremes, it has become imperative to understand and evaluate the impact weight extremes have on the pharmacokinetics of life‐sustaining immunosuppression in this population. This review will describe pharmacokinetic and dosing considerations for weight extremes in solid organ transplant recipients, including changes following bariatric surgeries, non‐pharmacologic and pharmacologic management strategies for weight loss and gain, and potential drug‐drug interactions with popular weight management products. |
| doi_str_mv | 10.1002/phar.2493 |
| format | Article |
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As solid organ transplant programs expand their candidate selection criteria to accommodate a growing population of patients with weight extremes, it has become imperative to understand and evaluate the impact weight extremes have on the pharmacokinetics of life‐sustaining immunosuppression in this population. This review will describe pharmacokinetic and dosing considerations for weight extremes in solid organ transplant recipients, including changes following bariatric surgeries, non‐pharmacologic and pharmacologic management strategies for weight loss and gain, and potential drug‐drug interactions with popular weight management products.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1002/phar.2493</identifier><identifier>PMID: 33301647</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>BMI ; Body mass index ; Body weight ; Body weight loss ; Gastrointestinal surgery ; Immunosuppression ; immunotherapy ; obesity ; Overweight ; Pharmacokinetics ; Surgery ; transplant ; Transplantation ; Transplants & implants ; Underweight ; Weight control</subject><ispartof>Pharmacotherapy, 2021-01, Vol.41 (1), p.44-58</ispartof><rights>2021 Pharmacotherapy Publications, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-563ed4dadb13fb866616abf0730725836aa42a41eb46e052884bf9ab4f883d503</citedby><cites>FETCH-LOGICAL-c3533-563ed4dadb13fb866616abf0730725836aa42a41eb46e052884bf9ab4f883d503</cites><orcidid>0000-0003-3402-4716 ; 0000-0001-5207-8633</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fphar.2493$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fphar.2493$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33301647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campara, Maya</creatorcontrib><creatorcontrib>Lourenco, Laura M.</creatorcontrib><creatorcontrib>Melaragno, Jennifer I.</creatorcontrib><creatorcontrib>Kaiser, Tiffany E.</creatorcontrib><title>Implications for body weight extremes in solid organ transplantation</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>The pharmacokinetic profiles of medications are altered in overweight and underweight patients, but few studies have described these differences in patients with body mass index extremes. 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This review will describe pharmacokinetic and dosing considerations for weight extremes in solid organ transplant recipients, including changes following bariatric surgeries, non‐pharmacologic and pharmacologic management strategies for weight loss and gain, and potential drug‐drug interactions with popular weight management products.</description><subject>BMI</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Gastrointestinal surgery</subject><subject>Immunosuppression</subject><subject>immunotherapy</subject><subject>obesity</subject><subject>Overweight</subject><subject>Pharmacokinetics</subject><subject>Surgery</subject><subject>transplant</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Underweight</subject><subject>Weight control</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EoqWw4AeQJVYs0o4fcdxlVR6tVAmEYB3ZjdOmSuJgpyr5e9wH7FjNLM49o7kI3RIYEgA6atbKDSkfszPUJzKJozEh_Bz1gSZJBACyh6683wSUCE4vUY8xBmFN-uhxXjVlsVRtYWuPc-uwtlmHd6ZYrVtsvltnKuNxUWNvyyLD1q1UjVunat-Uqm4PwWt0kavSm5vTHKDP56eP6SxavL7Mp5NFtGQxY1EsmMl4pjJNWK6lEIIIpXNIGCQ0lkwoxanixGguDMRUSq7zsdI8l5JlMbABuj96G2e_tsa36cZuXR1OpuF74BS4JIF6OFJLZ713Jk8bV1TKdSmBdN9Xuu9rn2CBvTsZt7oy2R_5W1AARkdgV5Sm-9-Uvs0m7wflDxYqdIE</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Campara, Maya</creator><creator>Lourenco, Laura M.</creator><creator>Melaragno, Jennifer I.</creator><creator>Kaiser, Tiffany E.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-3402-4716</orcidid><orcidid>https://orcid.org/0000-0001-5207-8633</orcidid></search><sort><creationdate>202101</creationdate><title>Implications for body weight extremes in solid organ transplantation</title><author>Campara, Maya ; Lourenco, Laura M. ; Melaragno, Jennifer I. ; Kaiser, Tiffany E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-563ed4dadb13fb866616abf0730725836aa42a41eb46e052884bf9ab4f883d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>BMI</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Gastrointestinal surgery</topic><topic>Immunosuppression</topic><topic>immunotherapy</topic><topic>obesity</topic><topic>Overweight</topic><topic>Pharmacokinetics</topic><topic>Surgery</topic><topic>transplant</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Underweight</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campara, Maya</creatorcontrib><creatorcontrib>Lourenco, Laura M.</creatorcontrib><creatorcontrib>Melaragno, Jennifer I.</creatorcontrib><creatorcontrib>Kaiser, Tiffany E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campara, Maya</au><au>Lourenco, Laura M.</au><au>Melaragno, Jennifer I.</au><au>Kaiser, Tiffany E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications for body weight extremes in solid organ transplantation</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>2021-01</date><risdate>2021</risdate><volume>41</volume><issue>1</issue><spage>44</spage><epage>58</epage><pages>44-58</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><abstract>The pharmacokinetic profiles of medications are altered in overweight and underweight patients, but few studies have described these differences in patients with body mass index extremes. 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| identifier | ISSN: 0277-0008 |
| ispartof | Pharmacotherapy, 2021-01, Vol.41 (1), p.44-58 |
| issn | 0277-0008 1875-9114 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | BMI Body mass index Body weight Body weight loss Gastrointestinal surgery Immunosuppression immunotherapy obesity Overweight Pharmacokinetics Surgery transplant Transplantation Transplants & implants Underweight Weight control |
| title | Implications for body weight extremes in solid organ transplantation |
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