Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal
Understanding individual variation in fitness‐related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological...
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| Veröffentlicht in: | Journal of evolutionary biology 2021-02, Vol.34 (2), p.296-308 |
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| creator | Lieshout, Sil H. J. Sparks, Alexandra M. Bretman, Amanda Newman, Chris Buesching, Christina D. Burke, Terry Macdonald, David W. Dugdale, Hannah L. |
| description | Understanding individual variation in fitness‐related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological consequences of environmental conditions. The relative contribution of genetic and environmental factors to individual variation in telomere length is, however, unclear, yet important for understanding its evolutionary dynamics. In particular, the evidence for transgenerational effects, in terms of parental age at conception, on telomere length is mixed. Here, we investigate the heritability of telomere length, using the ‘animal model’, and parental age at conception effects on offspring telomere length in a wild population of European badgers (Meles meles). Although we found no heritability of telomere length and low evolvability ( |
| doi_str_mv | 10.1111/jeb.13728 |
| format | Article |
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Understanding the evolutionary potential of traits requires estimation of the forces of natural selection and the heritability of a trait. Here, we determined the heritability of telomere length in a wild population of European badgers (Meles meles), as well as any transgenerational effects in the form of parental age at conception effects. We found no evidence for either heritability of telomere length nor for (sex‐specific) parental age at conception effects. However, we found evidence that variation in telomere length in badgers is driven by environmental variation.</description><identifier>ISSN: 1010-061X</identifier><identifier>EISSN: 1420-9101</identifier><identifier>DOI: 10.1111/jeb.13728</identifier><identifier>PMID: 33113164</identifier><language>eng</language><publisher>Switzerland: Blackwell Publishing Ltd</publisher><subject>Age ; Animal models ; Biomarkers ; Chromosomes ; Environmental conditions ; Environmental factors ; Genetic crosses ; Heritability ; Mammals ; Meles meles ; Offspring ; parental age at conception ; Phenotypic variations ; Senescence ; telomere length ; Telomeres ; wild mammal ; Yeast</subject><ispartof>Journal of evolutionary biology, 2021-02, Vol.34 (2), p.296-308</ispartof><rights>2020 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2020 European Society For Evolutionary Biology</rights><rights>2020 European Society For Evolutionary Biology. 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J.</creatorcontrib><creatorcontrib>Sparks, Alexandra M.</creatorcontrib><creatorcontrib>Bretman, Amanda</creatorcontrib><creatorcontrib>Newman, Chris</creatorcontrib><creatorcontrib>Buesching, Christina D.</creatorcontrib><creatorcontrib>Burke, Terry</creatorcontrib><creatorcontrib>Macdonald, David W.</creatorcontrib><creatorcontrib>Dugdale, Hannah L.</creatorcontrib><title>Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal</title><title>Journal of evolutionary biology</title><addtitle>J Evol Biol</addtitle><description>Understanding individual variation in fitness‐related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological consequences of environmental conditions. The relative contribution of genetic and environmental factors to individual variation in telomere length is, however, unclear, yet important for understanding its evolutionary dynamics. In particular, the evidence for transgenerational effects, in terms of parental age at conception, on telomere length is mixed. Here, we investigate the heritability of telomere length, using the ‘animal model’, and parental age at conception effects on offspring telomere length in a wild population of European badgers (Meles meles). Although we found no heritability of telomere length and low evolvability (<0.001), our power to detect heritability was low and a repeatability of 2% across individual lifetimes provides a low upper limit to ordinary narrow‐sense heritability. However, year (32%) and cohort (3%) explained greater proportions of the phenotypic variance in telomere length, excluding qPCR plate and row variances. There was no support for cross‐sectional or within‐individual parental age at conception effects on offspring telomere length. Our results indicate a lack of transgenerational effects through parental age at conception and a low potential for evolutionary change in telomere length in this population. Instead, we provide evidence that individual variation in telomere length is largely driven by environmental variation in this wild mammal.
Understanding the evolutionary potential of traits requires estimation of the forces of natural selection and the heritability of a trait. Here, we determined the heritability of telomere length in a wild population of European badgers (Meles meles), as well as any transgenerational effects in the form of parental age at conception effects. We found no evidence for either heritability of telomere length nor for (sex‐specific) parental age at conception effects. However, we found evidence that variation in telomere length in badgers is driven by environmental variation.</description><subject>Age</subject><subject>Animal models</subject><subject>Biomarkers</subject><subject>Chromosomes</subject><subject>Environmental conditions</subject><subject>Environmental factors</subject><subject>Genetic crosses</subject><subject>Heritability</subject><subject>Mammals</subject><subject>Meles meles</subject><subject>Offspring</subject><subject>parental age at conception</subject><subject>Phenotypic variations</subject><subject>Senescence</subject><subject>telomere length</subject><subject>Telomeres</subject><subject>wild mammal</subject><subject>Yeast</subject><issn>1010-061X</issn><issn>1420-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMotlYP_gEJeBLcNrPJdrNHLfWLghcFb0uandQtu0nNpkr_vbGt3sxlJsOTd8hDyDmwIcQzWuJ8CDxP5QHpg0hZUgCDw9gzYAkbw1uPnHTdkjEYiyw7Jj3OAXi89ImbdqFuVaidpc5QtJ-1d7ZFG1RzTRdoMdSaKlvRlfLbKVULpCpQ7azG1fYhGoM6dDS2ARvXokfaoF2Ed1pbquhX3VS0VW2rmlNyZFTT4dm-Dsjr3fRl8pDMnu8fJzezRHMpZZJxqQ1kqFmlUzmvsgq0FAYqIVBJCQwznWlZoElFrkRhjEoLiSlwVQk-zvmAXO5yV959rLEL5dKtvY0ry1QUjOUszUWkrnaU9q7rPJpy5aMNvymBlT9qy6i23KqN7MU-cT1vsfojf11GYLQD4ndx839S-TS93UV-A80ug1w</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Lieshout, Sil H. 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J.</creatorcontrib><creatorcontrib>Sparks, Alexandra M.</creatorcontrib><creatorcontrib>Bretman, Amanda</creatorcontrib><creatorcontrib>Newman, Chris</creatorcontrib><creatorcontrib>Buesching, Christina D.</creatorcontrib><creatorcontrib>Burke, Terry</creatorcontrib><creatorcontrib>Macdonald, David W.</creatorcontrib><creatorcontrib>Dugdale, Hannah L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of evolutionary biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lieshout, Sil H. J.</au><au>Sparks, Alexandra M.</au><au>Bretman, Amanda</au><au>Newman, Chris</au><au>Buesching, Christina D.</au><au>Burke, Terry</au><au>Macdonald, David W.</au><au>Dugdale, Hannah L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal</atitle><jtitle>Journal of evolutionary biology</jtitle><addtitle>J Evol Biol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>34</volume><issue>2</issue><spage>296</spage><epage>308</epage><pages>296-308</pages><issn>1010-061X</issn><eissn>1420-9101</eissn><abstract>Understanding individual variation in fitness‐related traits requires separating the environmental and genetic determinants. Telomeres are protective caps at the ends of chromosomes that are thought to be a biomarker of senescence as their length predicts mortality risk and reflect the physiological consequences of environmental conditions. The relative contribution of genetic and environmental factors to individual variation in telomere length is, however, unclear, yet important for understanding its evolutionary dynamics. In particular, the evidence for transgenerational effects, in terms of parental age at conception, on telomere length is mixed. Here, we investigate the heritability of telomere length, using the ‘animal model’, and parental age at conception effects on offspring telomere length in a wild population of European badgers (Meles meles). Although we found no heritability of telomere length and low evolvability (<0.001), our power to detect heritability was low and a repeatability of 2% across individual lifetimes provides a low upper limit to ordinary narrow‐sense heritability. However, year (32%) and cohort (3%) explained greater proportions of the phenotypic variance in telomere length, excluding qPCR plate and row variances. There was no support for cross‐sectional or within‐individual parental age at conception effects on offspring telomere length. Our results indicate a lack of transgenerational effects through parental age at conception and a low potential for evolutionary change in telomere length in this population. Instead, we provide evidence that individual variation in telomere length is largely driven by environmental variation in this wild mammal.
Understanding the evolutionary potential of traits requires estimation of the forces of natural selection and the heritability of a trait. Here, we determined the heritability of telomere length in a wild population of European badgers (Meles meles), as well as any transgenerational effects in the form of parental age at conception effects. We found no evidence for either heritability of telomere length nor for (sex‐specific) parental age at conception effects. However, we found evidence that variation in telomere length in badgers is driven by environmental variation.</abstract><cop>Switzerland</cop><pub>Blackwell Publishing Ltd</pub><pmid>33113164</pmid><doi>10.1111/jeb.13728</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4421-3337</orcidid><orcidid>https://orcid.org/0000-0003-4136-265X</orcidid><orcidid>https://orcid.org/0000-0002-9284-6526</orcidid><orcidid>https://orcid.org/0000-0003-0607-9373</orcidid><orcidid>https://orcid.org/0000-0001-8769-0099</orcidid><orcidid>https://orcid.org/0000-0003-3848-1244</orcidid><orcidid>https://orcid.org/0000-0002-7697-4632</orcidid><orcidid>https://orcid.org/0000-0002-4207-5196</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Age Animal models Biomarkers Chromosomes Environmental conditions Environmental factors Genetic crosses Heritability Mammals Meles meles Offspring parental age at conception Phenotypic variations Senescence telomere length Telomeres wild mammal Yeast |
| title | Estimation of environmental, genetic and parental age at conception effects on telomere length in a wild mammal |
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