Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats
This study aims to explore the protective effects of quercetin against cadmium-induced nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2 (4.89 mg/kg·bw) and d...
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| Veröffentlicht in: | Biometals 2021-02, Vol.34 (1), p.33-48 |
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| creator | Guan, Tong Xin, Youwei Zheng, Kai Wang, Ruijuan Zhang, Xia Jia, Siqi Li, Siqi Cao, Can Zhao, Xiujuan |
| description | This study aims to explore the protective effects of quercetin against cadmium-induced nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2 (4.89 mg/kg·bw) and different dosages quercetin plus CdCl2 groups. After 12 weeks, the kidneys were collected for metabolomics analysis and histopathology examination. In total, 11 metabolites were confirmed, the intensities of which significantly changed (up-regulated or down-regulated) compared with the control group (p |
| doi_str_mv | 10.1007/s10534-020-00260-2 |
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Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2 (4.89 mg/kg·bw) and different dosages quercetin plus CdCl2 groups. After 12 weeks, the kidneys were collected for metabolomics analysis and histopathology examination. In total, 11 metabolites were confirmed, the intensities of which significantly changed (up-regulated or down-regulated) compared with the control group (p < 0.00067). These metabolites include xanthosine, uric acid (UA), guanidinosuccinic acid (GSA), hypoxanthine (Hyp), 12-hydroxyeicosatetraenoic acid (tetranor 12-HETE), taurocholic acid (TCA), hydroxyphenylacetylglycine (HPAG), deoxyinosine (DI), ATP, formiminoglutamic acid (FIGLU) and arachidonic acid (AA). When high-dose quercetin and cadmium were given to rats concurrently, the intensities of above metabolites significantly restored (p < 0.0033 or p < 0.00067). The results showed quercetin attenuated Cd-induced nephrotoxicity by regulating the metabolism of lipids, amino acids, and purine, inhibiting oxidative stress, and protecting kidney functions.</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-020-00260-2</identifier><identifier>PMID: 33033991</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Amino acids ; Arachidonic acid ; Biochemistry ; Biomedical and Life Sciences ; Cadmium ; Cadmium chloride ; Cell Biology ; Dosage ; Histopathology ; Hypoxanthine ; Kidneys ; Life Sciences ; Lipid metabolism ; Lipids ; Medicine/Public Health ; Metabolites ; Metabolomics ; Microbiology ; Oxidative stress ; Pharmacology/Toxicology ; Plant Physiology ; Quercetin ; Taurocholic acid ; Toxicity ; Uric acid</subject><ispartof>Biometals, 2021-02, Vol.34 (1), p.33-48</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4fb5c7cb349b399ced1df227e683b6e84604a39fc88e6f537eaaede1851a56cd3</citedby><cites>FETCH-LOGICAL-c375t-4fb5c7cb349b399ced1df227e683b6e84604a39fc88e6f537eaaede1851a56cd3</cites><orcidid>0000-0001-6953-4148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10534-020-00260-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10534-020-00260-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33033991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guan, Tong</creatorcontrib><creatorcontrib>Xin, Youwei</creatorcontrib><creatorcontrib>Zheng, Kai</creatorcontrib><creatorcontrib>Wang, Ruijuan</creatorcontrib><creatorcontrib>Zhang, Xia</creatorcontrib><creatorcontrib>Jia, Siqi</creatorcontrib><creatorcontrib>Li, Siqi</creatorcontrib><creatorcontrib>Cao, Can</creatorcontrib><creatorcontrib>Zhao, Xiujuan</creatorcontrib><title>Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>This study aims to explore the protective effects of quercetin against cadmium-induced nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2 (4.89 mg/kg·bw) and different dosages quercetin plus CdCl2 groups. After 12 weeks, the kidneys were collected for metabolomics analysis and histopathology examination. In total, 11 metabolites were confirmed, the intensities of which significantly changed (up-regulated or down-regulated) compared with the control group (p < 0.00067). These metabolites include xanthosine, uric acid (UA), guanidinosuccinic acid (GSA), hypoxanthine (Hyp), 12-hydroxyeicosatetraenoic acid (tetranor 12-HETE), taurocholic acid (TCA), hydroxyphenylacetylglycine (HPAG), deoxyinosine (DI), ATP, formiminoglutamic acid (FIGLU) and arachidonic acid (AA). When high-dose quercetin and cadmium were given to rats concurrently, the intensities of above metabolites significantly restored (p < 0.0033 or p < 0.00067). The results showed quercetin attenuated Cd-induced nephrotoxicity by regulating the metabolism of lipids, amino acids, and purine, inhibiting oxidative stress, and protecting kidney functions.</description><subject>Amino acids</subject><subject>Arachidonic acid</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cadmium</subject><subject>Cadmium chloride</subject><subject>Cell Biology</subject><subject>Dosage</subject><subject>Histopathology</subject><subject>Hypoxanthine</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Medicine/Public Health</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Microbiology</subject><subject>Oxidative stress</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Physiology</subject><subject>Quercetin</subject><subject>Taurocholic acid</subject><subject>Toxicity</subject><subject>Uric acid</subject><issn>0966-0844</issn><issn>1572-8773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1PxCAQhonR6Lr6BzwYEs_VAVpoj8b4lWi86JlQOqw127ICTdx_L-76cfNEJvPMy5uHkBMG5wxAXUQGlSgL4FAAcAkF3yEzVile1EqJXTKDRsoC6rI8IIcxvgFAo0DukwMhQIimYTOyeMRkWr_0Q28jNaNZrmMfqXc0vSJF59Cmzfg-YbCY-pH6kQbMIE3-o7d9WtN-7CaLHW3X1Jpu6KeB4sfKxylg3tFgUjwie84sIx5_v3PycnP9fHVXPDzd3l9dPhRWqCoVpWsrq2wryqbNBXMo6xznCmUtWol1KaE0onG2rlG6Sig0BjtkdcVMJW0n5uRsm7sKPleOSb_5KeS2UfOybhqoFINM8S1lg48xoNOr0A8mrDUD_eVWb93q7FZv3Gqej06_o6d2wO735EdmBsQWiHk1LjD8_f1P7CceaoYG</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Guan, Tong</creator><creator>Xin, Youwei</creator><creator>Zheng, Kai</creator><creator>Wang, Ruijuan</creator><creator>Zhang, Xia</creator><creator>Jia, Siqi</creator><creator>Li, Siqi</creator><creator>Cao, Can</creator><creator>Zhao, Xiujuan</creator><general>Springer 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analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats</title><author>Guan, Tong ; Xin, Youwei ; Zheng, Kai ; Wang, Ruijuan ; Zhang, Xia ; Jia, Siqi ; Li, Siqi ; Cao, Can ; Zhao, Xiujuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4fb5c7cb349b399ced1df227e683b6e84604a39fc88e6f537eaaede1851a56cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino acids</topic><topic>Arachidonic acid</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cadmium</topic><topic>Cadmium chloride</topic><topic>Cell Biology</topic><topic>Dosage</topic><topic>Histopathology</topic><topic>Hypoxanthine</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Medicine/Public Health</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Microbiology</topic><topic>Oxidative stress</topic><topic>Pharmacology/Toxicology</topic><topic>Plant Physiology</topic><topic>Quercetin</topic><topic>Taurocholic acid</topic><topic>Toxicity</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Tong</creatorcontrib><creatorcontrib>Xin, Youwei</creatorcontrib><creatorcontrib>Zheng, Kai</creatorcontrib><creatorcontrib>Wang, Ruijuan</creatorcontrib><creatorcontrib>Zhang, Xia</creatorcontrib><creatorcontrib>Jia, Siqi</creatorcontrib><creatorcontrib>Li, Siqi</creatorcontrib><creatorcontrib>Cao, Can</creatorcontrib><creatorcontrib>Zhao, Xiujuan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research 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rats</atitle><jtitle>Biometals</jtitle><stitle>Biometals</stitle><addtitle>Biometals</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>34</volume><issue>1</issue><spage>33</spage><epage>48</epage><pages>33-48</pages><issn>0966-0844</issn><eissn>1572-8773</eissn><abstract>This study aims to explore the protective effects of quercetin against cadmium-induced nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2 (4.89 mg/kg·bw) and different dosages quercetin plus CdCl2 groups. After 12 weeks, the kidneys were collected for metabolomics analysis and histopathology examination. In total, 11 metabolites were confirmed, the intensities of which significantly changed (up-regulated or down-regulated) compared with the control group (p < 0.00067). These metabolites include xanthosine, uric acid (UA), guanidinosuccinic acid (GSA), hypoxanthine (Hyp), 12-hydroxyeicosatetraenoic acid (tetranor 12-HETE), taurocholic acid (TCA), hydroxyphenylacetylglycine (HPAG), deoxyinosine (DI), ATP, formiminoglutamic acid (FIGLU) and arachidonic acid (AA). When high-dose quercetin and cadmium were given to rats concurrently, the intensities of above metabolites significantly restored (p < 0.0033 or p < 0.00067). The results showed quercetin attenuated Cd-induced nephrotoxicity by regulating the metabolism of lipids, amino acids, and purine, inhibiting oxidative stress, and protecting kidney functions.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33033991</pmid><doi>10.1007/s10534-020-00260-2</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-6953-4148</orcidid></addata></record> |
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| subjects | Amino acids Arachidonic acid Biochemistry Biomedical and Life Sciences Cadmium Cadmium chloride Cell Biology Dosage Histopathology Hypoxanthine Kidneys Life Sciences Lipid metabolism Lipids Medicine/Public Health Metabolites Metabolomics Microbiology Oxidative stress Pharmacology/Toxicology Plant Physiology Quercetin Taurocholic acid Toxicity Uric acid |
| title | Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats |
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