Influence of dabigatran on pro-inflammatory cytokines, growth factors and chemokines – Slowing the vicious circle of coagulation and inflammation

Blood coagulation is one of the most important host-defending mechanisms in vivo by maintaining the blood pressure after injury. However, besides maintaining homeostasis, blood coagulation and the contributing factors are directly linked to pathological conditions, such as thromboembolism and inflam...

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Veröffentlicht in:	Life sciences (1973) 2020-12, Vol.262, p.118474-12, Article 118474
Hauptverfasser:	Paar, Vera, Jirak, Peter, Gruber, Susanne, Prodinger, Christine, Cadamuro, Janne, Wernly, Bernhard, Motloch, Lukas J., Haschke-Becher, Elisabeth, Hoppe, Uta C., Lichtenauer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-inflammatory agents Anticoagulants Antithrombins - administration & dosage Antithrombins - pharmacology Blood coagulation Blood Coagulation - drug effects Blood pressure Cardiovascular diseases Cells, Cultured Chemokines Chemokines - metabolism Coagulation Cytokines Cytokines - metabolism Dabigatran Dabigatran - administration & dosage Dabigatran - pharmacology Dose-Response Relationship, Drug Ethylenediaminetetraacetic acids Growth factors Homeostasis Humans In vitro methods and tests Inflammation Inflammation - drug therapy Inflammation - pathology Inflammatory cytokines Intercellular Signaling Peptides and Proteins - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism PBMC Pretreatment Proteins Ribonuclease, Pancreatic - metabolism Secretome Serum Thrombin Thromboembolism Tubes
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