Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl2 pathway

Donepezil (DNPZ) has shown neuroprotective effect in many disorders. The current study tested the putative retinoprotection provided by donepezil in mouse diabetic retinopathy. Swiss albino mice were allocated to, 1] saline control, 2] diabetic, 3&4] diabetic+DNPZ (1 or 4 mg/kg). After induction...

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Veröffentlicht in:	Life sciences (1973) 2020-12, Vol.262, p.118467-14, Article 118467
Hauptverfasser:	Zaitone, Sawsan A., Alshaman, Reem, Alattar, Abdullah, Elsherbiny, Nehal M., Abogresha, Noha M., El-Kherbetawy, Mohammed K., Elaskary, Abdelhakeem A., Hashish, Abdullah A., Rashed, Laila A., Ahmed, Eman
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acetylcholine Apoptosis B-cell lymphoma Beta cells Caspase-3 Cytokines Diabetes Diabetes mellitus Diabetic retinopathy Donepezil Excitotoxicity Glutamate Glutamic acid receptors Histopathology Immunohistochemistry Inflammation Kinases Lymphoma Mitigation Mouse N-Methyl-D-aspartic acid receptors Neuroprotection Oxidation Phosphorylation PI3K/mTOR/BCl2 Proteins Retina Retinopathy Thickness TOR protein
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