Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity
f. , not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of f. were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl a...
Gespeichert in:
| Veröffentlicht in: | Holzforschung 2018-12, Vol.72 (12), p.1017-1024 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1024 |
|---|---|
| container_issue | 12 |
| container_start_page | 1017 |
| container_title | Holzforschung |
| container_volume | 72 |
| creator | Zhao, Chunchao Chen, Jia Shao, Jianhua Shen, Jie Xu, Xiaoqing Li, Kehuan Gu, Wenyan Zhao, Min Fan, Judi |
| description | f.
, not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of
f.
were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl acetate and
-butanol. Among the different fractions, the ethyl acetate fraction exhibited the highest
-glucosidase inhibitory activity, and its bioassay-guided fractionation led to the isolation and identification of six compounds including a new 8-
-4′-neolignan glycoside (
), categorized as a rare 7-deoxy skeleton, three previously undescribed phenolic glycosides (
), together with two known secondary metabolites (
,
), which were found for the first time in
. Noticeably, compound
had almost the same intestinal
-glucosidase inhibitory activity as the positive control acarbose. |
| doi_str_mv | 10.1515/hf-2018-0081 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2489037297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2489037297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-c4578b482e0ba2016cf861593f59d60a87a09bae0b40c53f4e44bb5173e8f3733</originalsourceid><addsrcrecordid>eNptUM1OxCAYJEYT19WbD0Di1SoUuqWJF2P8SzbxosZbQ9mPLdqFClTT9_BFfBGfSdY18eIJ5mNmPmYQOqTkhBa0OG11lhMqMkIE3UITylmZccafttGErOdMMLKL9kJ4TrAgjE7Qx21wnYzGWew0tuA6s7TSYmkXuG_BJqzwshuVC2YBAWvvVji2gBsvrWrTJMkeTTN4O6zwSirvFPSt7BLSJ_gFInQA3vwYJp3x-OszW3bDj6EMgI1tTWOi8yOWKpo3E8d9tKNlF-Dg95yih6vL-4ubbH53fXtxPs8Uo7OYKV6UouEiB9LIFHymtJjRomK6qBYzIkUpSdXI9MqJKpjmwHnTFLRkIDQrGZuio41v793rACHWzy4FSSvrnIuKsDKvysQ63rBSthA86Lr3ZiX9WFNSr3uvW12ve6_XvSf62Yb-LrsIfgFLP4zp8uf9n6zMaU5J-to39hmMjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489037297</pqid></control><display><type>article</type><title>Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity</title><source>De Gruyter journals</source><creator>Zhao, Chunchao ; Chen, Jia ; Shao, Jianhua ; Shen, Jie ; Xu, Xiaoqing ; Li, Kehuan ; Gu, Wenyan ; Zhao, Min ; Fan, Judi</creator><creatorcontrib>Zhao, Chunchao ; Chen, Jia ; Shao, Jianhua ; Shen, Jie ; Xu, Xiaoqing ; Li, Kehuan ; Gu, Wenyan ; Zhao, Min ; Fan, Judi</creatorcontrib><description>f.
, not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of
f.
were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl acetate and
-butanol. Among the different fractions, the ethyl acetate fraction exhibited the highest
-glucosidase inhibitory activity, and its bioassay-guided fractionation led to the isolation and identification of six compounds including a new 8-
-4′-neolignan glycoside (
), categorized as a rare 7-deoxy skeleton, three previously undescribed phenolic glycosides (
), together with two known secondary metabolites (
,
), which were found for the first time in
. Noticeably, compound
had almost the same intestinal
-glucosidase inhibitory activity as the positive control acarbose.</description><identifier>ISSN: 0018-3830</identifier><identifier>EISSN: 1437-434X</identifier><identifier>DOI: 10.1515/hf-2018-0081</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Acarbose ; Acetic acid ; Adoxaceae ; Bioassays ; Butanol ; Diabetes mellitus (non-insulin dependent) ; Ethanol ; Ethyl acetate ; extractives ; Fractionation ; Glucosidase ; glucosidase inhibitory activity ; Glycosides ; Intestine ; Metabolites ; neolignan glycoside ; Phenolic compounds ; phenolic glycoside ; Phenols ; Polarity ; Secondary metabolites ; Viburnum macrocephalum f. keteleeri ; α-Glucosidase</subject><ispartof>Holzforschung, 2018-12, Vol.72 (12), p.1017-1024</ispartof><rights>2018 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-c4578b482e0ba2016cf861593f59d60a87a09bae0b40c53f4e44bb5173e8f3733</citedby><cites>FETCH-LOGICAL-c316t-c4578b482e0ba2016cf861593f59d60a87a09bae0b40c53f4e44bb5173e8f3733</cites><orcidid>0000-0001-7941-8175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/hf-2018-0081/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/hf-2018-0081/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,66525,68309</link.rule.ids></links><search><creatorcontrib>Zhao, Chunchao</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Shao, Jianhua</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><creatorcontrib>Xu, Xiaoqing</creatorcontrib><creatorcontrib>Li, Kehuan</creatorcontrib><creatorcontrib>Gu, Wenyan</creatorcontrib><creatorcontrib>Zhao, Min</creatorcontrib><creatorcontrib>Fan, Judi</creatorcontrib><title>Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity</title><title>Holzforschung</title><description>f.
, not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of
f.
were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl acetate and
-butanol. Among the different fractions, the ethyl acetate fraction exhibited the highest
-glucosidase inhibitory activity, and its bioassay-guided fractionation led to the isolation and identification of six compounds including a new 8-
-4′-neolignan glycoside (
), categorized as a rare 7-deoxy skeleton, three previously undescribed phenolic glycosides (
), together with two known secondary metabolites (
,
), which were found for the first time in
. Noticeably, compound
had almost the same intestinal
-glucosidase inhibitory activity as the positive control acarbose.</description><subject>Acarbose</subject><subject>Acetic acid</subject><subject>Adoxaceae</subject><subject>Bioassays</subject><subject>Butanol</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Ethanol</subject><subject>Ethyl acetate</subject><subject>extractives</subject><subject>Fractionation</subject><subject>Glucosidase</subject><subject>glucosidase inhibitory activity</subject><subject>Glycosides</subject><subject>Intestine</subject><subject>Metabolites</subject><subject>neolignan glycoside</subject><subject>Phenolic compounds</subject><subject>phenolic glycoside</subject><subject>Phenols</subject><subject>Polarity</subject><subject>Secondary metabolites</subject><subject>Viburnum macrocephalum f. keteleeri</subject><subject>α-Glucosidase</subject><issn>0018-3830</issn><issn>1437-434X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNptUM1OxCAYJEYT19WbD0Di1SoUuqWJF2P8SzbxosZbQ9mPLdqFClTT9_BFfBGfSdY18eIJ5mNmPmYQOqTkhBa0OG11lhMqMkIE3UITylmZccafttGErOdMMLKL9kJ4TrAgjE7Qx21wnYzGWew0tuA6s7TSYmkXuG_BJqzwshuVC2YBAWvvVji2gBsvrWrTJMkeTTN4O6zwSirvFPSt7BLSJ_gFInQA3vwYJp3x-OszW3bDj6EMgI1tTWOi8yOWKpo3E8d9tKNlF-Dg95yih6vL-4ubbH53fXtxPs8Uo7OYKV6UouEiB9LIFHymtJjRomK6qBYzIkUpSdXI9MqJKpjmwHnTFLRkIDQrGZuio41v793rACHWzy4FSSvrnIuKsDKvysQ63rBSthA86Lr3ZiX9WFNSr3uvW12ve6_XvSf62Yb-LrsIfgFLP4zp8uf9n6zMaU5J-to39hmMjw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Zhao, Chunchao</creator><creator>Chen, Jia</creator><creator>Shao, Jianhua</creator><creator>Shen, Jie</creator><creator>Xu, Xiaoqing</creator><creator>Li, Kehuan</creator><creator>Gu, Wenyan</creator><creator>Zhao, Min</creator><creator>Fan, Judi</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-7941-8175</orcidid></search><sort><creationdate>20181201</creationdate><title>Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity</title><author>Zhao, Chunchao ; Chen, Jia ; Shao, Jianhua ; Shen, Jie ; Xu, Xiaoqing ; Li, Kehuan ; Gu, Wenyan ; Zhao, Min ; Fan, Judi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-c4578b482e0ba2016cf861593f59d60a87a09bae0b40c53f4e44bb5173e8f3733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acarbose</topic><topic>Acetic acid</topic><topic>Adoxaceae</topic><topic>Bioassays</topic><topic>Butanol</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Ethanol</topic><topic>Ethyl acetate</topic><topic>extractives</topic><topic>Fractionation</topic><topic>Glucosidase</topic><topic>glucosidase inhibitory activity</topic><topic>Glycosides</topic><topic>Intestine</topic><topic>Metabolites</topic><topic>neolignan glycoside</topic><topic>Phenolic compounds</topic><topic>phenolic glycoside</topic><topic>Phenols</topic><topic>Polarity</topic><topic>Secondary metabolites</topic><topic>Viburnum macrocephalum f. keteleeri</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Chunchao</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Shao, Jianhua</creatorcontrib><creatorcontrib>Shen, Jie</creatorcontrib><creatorcontrib>Xu, Xiaoqing</creatorcontrib><creatorcontrib>Li, Kehuan</creatorcontrib><creatorcontrib>Gu, Wenyan</creatorcontrib><creatorcontrib>Zhao, Min</creatorcontrib><creatorcontrib>Fan, Judi</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Holzforschung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Chunchao</au><au>Chen, Jia</au><au>Shao, Jianhua</au><au>Shen, Jie</au><au>Xu, Xiaoqing</au><au>Li, Kehuan</au><au>Gu, Wenyan</au><au>Zhao, Min</au><au>Fan, Judi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity</atitle><jtitle>Holzforschung</jtitle><date>2018-12-01</date><risdate>2018</risdate><volume>72</volume><issue>12</issue><spage>1017</spage><epage>1024</epage><pages>1017-1024</pages><issn>0018-3830</issn><eissn>1437-434X</eissn><abstract>f.
, not well explored in the pharmaceutical field, is a tall deciduous shrub and commonly used as folk medicines for the treatment of type 2 diabetes (T2D). In this study, the dried branches of
f.
were extracted with 95% ethanol and the extract was fractionated on the basis of polarity with ethyl acetate and
-butanol. Among the different fractions, the ethyl acetate fraction exhibited the highest
-glucosidase inhibitory activity, and its bioassay-guided fractionation led to the isolation and identification of six compounds including a new 8-
-4′-neolignan glycoside (
), categorized as a rare 7-deoxy skeleton, three previously undescribed phenolic glycosides (
), together with two known secondary metabolites (
,
), which were found for the first time in
. Noticeably, compound
had almost the same intestinal
-glucosidase inhibitory activity as the positive control acarbose.</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1515/hf-2018-0081</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7941-8175</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0018-3830 |
| ispartof | Holzforschung, 2018-12, Vol.72 (12), p.1017-1024 |
| issn | 0018-3830 1437-434X |
| language | eng |
| recordid | cdi_proquest_journals_2489037297 |
| source | De Gruyter journals |
| subjects | Acarbose Acetic acid Adoxaceae Bioassays Butanol Diabetes mellitus (non-insulin dependent) Ethanol Ethyl acetate extractives Fractionation Glucosidase glucosidase inhibitory activity Glycosides Intestine Metabolites neolignan glycoside Phenolic compounds phenolic glycoside Phenols Polarity Secondary metabolites Viburnum macrocephalum f. keteleeri α-Glucosidase |
| title | Isolation of neolignan and phenolic glycosides from the branches of Viburnum macrocephalum f. keteleeri and their α-glucosidase inhibitory activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T06%3A36%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Isolation%20of%20neolignan%20and%20phenolic%20glycosides%20from%20the%20branches%20of%20Viburnum%20macrocephalum%20f.%20keteleeri%20and%20their%20%CE%B1-glucosidase%20inhibitory%20activity&rft.jtitle=Holzforschung&rft.au=Zhao,%20Chunchao&rft.date=2018-12-01&rft.volume=72&rft.issue=12&rft.spage=1017&rft.epage=1024&rft.pages=1017-1024&rft.issn=0018-3830&rft.eissn=1437-434X&rft_id=info:doi/10.1515/hf-2018-0081&rft_dat=%3Cproquest_cross%3E2489037297%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489037297&rft_id=info:pmid/&rfr_iscdi=true |