Thiopyrimidine derivatives induce cytotoxicity, cell cycle arrest and oxidative stress in breast cancer 3D-spheroids

3D-cultured breast cancer cells had shown relative drug resistance as compared to 2D-cultured cells, and it has been suggested as a new in vitro cell-based drug-testing platform to look for novel antitumor molecule. Given the complexity of in vivo tumors and relative drug resistance, we evaluated a...

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