Mitochondrial Reactive Oxygen Species and Mitophagy: A Complex and Nuanced Relationship

Mitochondria represent a major source of intracellular reactive oxygen species (ROS) generation. This is often a consequence of oxidative phosphorylation, which can produce ROS as a result of leakage from the electron transport chain. In addition, quality control mechanisms exist to protect cells fr...

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Veröffentlicht in:	Antioxidants & redox signaling 2021-03, Vol.34 (7), p.517-530
Hauptverfasser:	Schofield, James H, Schafer, Zachary T
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell viability Cytotoxicity Electron transport Electron transport chain Mitochondria Mitophagy Oxidative phosphorylation Oxidative stress Phosphorylation Quality control Reactive oxygen species
Online-Zugang:	Volltext
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