Modulation of rifampicin-induced hepatotoxicity using poly(lactic-co-glycolic acid) nanoparticles: a study on rat and cell culture models
Hepatotoxicity is the most serious adverse effect of rifampicin (RIF). We aimed to investigate the potential hepatoprotective effect of mannose-functionalized poly(lactic-co-glycolic acid)(PLGA)/RIF nanoparticles (NPs) in rats as a possible promising approach to minimize RIF-induced hepatotoxicity....
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-06, Vol.15 (14), p.1375-1390 |
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| container_title | Nanomedicine (London, England) |
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| creator | Hetta, Helal F Ahmed, Esraa A Hemdan, Ahmed G El-Deek, Heba EM Abd-Elregal, Saida Abd Ellah, Noura H |
| description | Hepatotoxicity is the most serious adverse effect of rifampicin (RIF). We aimed to investigate the potential hepatoprotective effect of mannose-functionalized poly(lactic-co-glycolic acid)(PLGA)/RIF nanoparticles (NPs) in rats as a possible promising approach to minimize RIF-induced hepatotoxicity.
Mannose-functionalized PLGA/RIF NPs were fabricated and characterized
, then the hepatoprotective effect of optimized NPs was studied on rat and cell culture models.
Following intraperitoneal administration of RIF NPs into rats, highly significant differences in levels of serum transaminases and oxidative stress markers, associated with significant differences in expression of
and
genes between NP- and free RIF-treated groups, revealing the hepatoprotective potential of NPs.
RIF NPs may represent a promising therapeutic approach for tuberculosis via reducing dose frequency and consequently, RIF-induced hepatotoxicity. |
| doi_str_mv | 10.2217/nnm-2020-0001 |
| format | Article |
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Mannose-functionalized PLGA/RIF NPs were fabricated and characterized
, then the hepatoprotective effect of optimized NPs was studied on rat and cell culture models.
Following intraperitoneal administration of RIF NPs into rats, highly significant differences in levels of serum transaminases and oxidative stress markers, associated with significant differences in expression of
and
genes between NP- and free RIF-treated groups, revealing the hepatoprotective potential of NPs.
RIF NPs may represent a promising therapeutic approach for tuberculosis via reducing dose frequency and consequently, RIF-induced hepatotoxicity.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2020-0001</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>Apoptosis ; Efficiency ; hepatotoxicity ; Liver ; mannose ; Morphology ; Nanoparticles ; Oxidative stress ; Particle size ; Phenols ; PLGA ; Polymers ; rifampicin ; Spectrum analysis ; Transmission electron microscopy ; Tuberculosis</subject><ispartof>Nanomedicine (London, England), 2020-06, Vol.15 (14), p.1375-1390</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jun 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-8e247f7024c69af4cf7c055ca5d84f129103143f055d4f3048fde9995b448a413</citedby><cites>FETCH-LOGICAL-c348t-8e247f7024c69af4cf7c055ca5d84f129103143f055d4f3048fde9995b448a413</cites><orcidid>0000-0001-8541-7304</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Hetta, Helal F</creatorcontrib><creatorcontrib>Ahmed, Esraa A</creatorcontrib><creatorcontrib>Hemdan, Ahmed G</creatorcontrib><creatorcontrib>El-Deek, Heba EM</creatorcontrib><creatorcontrib>Abd-Elregal, Saida</creatorcontrib><creatorcontrib>Abd Ellah, Noura H</creatorcontrib><title>Modulation of rifampicin-induced hepatotoxicity using poly(lactic-co-glycolic acid) nanoparticles: a study on rat and cell culture models</title><title>Nanomedicine (London, England)</title><description>Hepatotoxicity is the most serious adverse effect of rifampicin (RIF). We aimed to investigate the potential hepatoprotective effect of mannose-functionalized poly(lactic-co-glycolic acid)(PLGA)/RIF nanoparticles (NPs) in rats as a possible promising approach to minimize RIF-induced hepatotoxicity.
Mannose-functionalized PLGA/RIF NPs were fabricated and characterized
, then the hepatoprotective effect of optimized NPs was studied on rat and cell culture models.
Following intraperitoneal administration of RIF NPs into rats, highly significant differences in levels of serum transaminases and oxidative stress markers, associated with significant differences in expression of
and
genes between NP- and free RIF-treated groups, revealing the hepatoprotective potential of NPs.
RIF NPs may represent a promising therapeutic approach for tuberculosis via reducing dose frequency and consequently, RIF-induced hepatotoxicity.</description><subject>Apoptosis</subject><subject>Efficiency</subject><subject>hepatotoxicity</subject><subject>Liver</subject><subject>mannose</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Oxidative stress</subject><subject>Particle size</subject><subject>Phenols</subject><subject>PLGA</subject><subject>Polymers</subject><subject>rifampicin</subject><subject>Spectrum analysis</subject><subject>Transmission electron microscopy</subject><subject>Tuberculosis</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kD1v3DAMho2iAXr5GLsLyNIMSiVZPsvZikM-CqToksyCQkkXHWTJ0QdQ_4T-69i9rJ1IvnxJgk_TfKXkmjHafw9hxIwwggkh9FOzoT0XeDts28__8hZ3QgxfmtOcD4R0glGyaf7-irp6VVwMKFqUnFXj5MAF7IKuYDR6NZMqscQ_i1pmVLMLezRFP3_zCooDDBHv_QzRO0AKnL5CQYU4qbQ0vck3SKFcqp7RciKpglTQCIz3CKovNRk0Rm18Pm9OrPLZXHzEs-b57vZp94Aff9__3P14xNByUbAwjPe2J4zDdlCWg-2BdB2oTgtuKRsoaSlv7aJpblvChdVmGIbuhXOhOG3Pmsvj3inFt2pykYdYU1hOSsZFzzmj3XZx4aMLUsw5GSun5EaVZkmJXGnLhbZcacuV9uIfjn5b158yOBPAyGM1Gr0iNf-ZfQfVFIhK</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Hetta, Helal F</creator><creator>Ahmed, Esraa A</creator><creator>Hemdan, Ahmed G</creator><creator>El-Deek, Heba EM</creator><creator>Abd-Elregal, Saida</creator><creator>Abd Ellah, Noura H</creator><general>Future Medicine Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-8541-7304</orcidid></search><sort><creationdate>20200601</creationdate><title>Modulation of rifampicin-induced hepatotoxicity using poly(lactic-co-glycolic acid) nanoparticles: a study on rat and cell culture models</title><author>Hetta, Helal F ; 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We aimed to investigate the potential hepatoprotective effect of mannose-functionalized poly(lactic-co-glycolic acid)(PLGA)/RIF nanoparticles (NPs) in rats as a possible promising approach to minimize RIF-induced hepatotoxicity.
Mannose-functionalized PLGA/RIF NPs were fabricated and characterized
, then the hepatoprotective effect of optimized NPs was studied on rat and cell culture models.
Following intraperitoneal administration of RIF NPs into rats, highly significant differences in levels of serum transaminases and oxidative stress markers, associated with significant differences in expression of
and
genes between NP- and free RIF-treated groups, revealing the hepatoprotective potential of NPs.
RIF NPs may represent a promising therapeutic approach for tuberculosis via reducing dose frequency and consequently, RIF-induced hepatotoxicity.</abstract><cop>London</cop><pub>Future Medicine Ltd</pub><doi>10.2217/nnm-2020-0001</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-8541-7304</orcidid></addata></record> |
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| source | PubMed Central |
| subjects | Apoptosis Efficiency hepatotoxicity Liver mannose Morphology Nanoparticles Oxidative stress Particle size Phenols PLGA Polymers rifampicin Spectrum analysis Transmission electron microscopy Tuberculosis |
| title | Modulation of rifampicin-induced hepatotoxicity using poly(lactic-co-glycolic acid) nanoparticles: a study on rat and cell culture models |
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