Investigation of the Substrate‐Binding Site of a Prostaglandin E Synthase in Bombyx mori

Prostaglandin E synthase (PGES) catalyzes the conversion of prostaglandin H 2 to prostaglandin E 2 in the presence of glutathione (GSH) in mammals. Amid the limited knowledge on prostaglandin and its related enzymes in insects, we recently identified PGES from the silkworm Bombyx mori (bmPGES) and d...

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Veröffentlicht in:	The Protein Journal 2021-02, Vol.40 (1), p.63-67
Hauptverfasser:	Yamamoto, Kohji, Hirowatari, Aiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Binding sites Biochemistry Bioorganic Chemistry Bombyx mori Catalytic activity Chemistry Chemistry and Materials Science Crystal structure Crystallography Crystals Enzymes Glutathione Histology Insects Morphology Mutagenesis Organic Chemistry Pest control Pesticides Pests Prostaglandin E Prostaglandin E2 Prostaglandin H2 Residues Silkworms Site-directed mutagenesis Structure Structure-function relationships Substrates Synthetic prostaglandins E X-ray crystallography
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