[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma

131I-labeled m-iodobenzylguanidine ([131I]MIBG) has been used to treat neuroblastoma patients, but [131I]MIBG may be immediately excreted from the cancer cells by the adenosine triphosphate binding cassette transporters, similar to anticancer drugs. The purpose of this study was to clarify the efflu...

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Veröffentlicht in:	Nuclear medicine and biology 2020-11, Vol.90-91, p.49-54
Hauptverfasser:	Kobayashi, Masato, Mizutani, Asuka, Nishi, Kodai, Muranaka, Yuka, Nishii, Ryuichi, Shikano, Naoto, Nakanishi, Takeo, Tamai, Ikumi, Kleinerman, Eugenie S., Kawai, Keiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Iodobenzylguanidine - metabolism [123/131I]MIBG Accumulation Adenosine triphosphate AMP Animals Anions Antineoplastic drugs Antitumor agents ATP Bile Biological Transport Blood Breast cancer Cell Line, Tumor Drug resistance Efflux Efflux transporter Exports Glycoproteins HEK293 Cells Humans Inhibitors Kidneys Material requirements planning MDR1 protein Mice MRP Multidrug resistance Multidrug Resistance-Associated Proteins - antagonists & inhibitors Multidrug Resistance-Associated Proteins - metabolism Muscles Neuroblastoma Neuroblastoma - diagnostic imaging Neuroblastoma - metabolism Neuroblastoma - pathology Neuroendocrine tumors Oct-2 protein Organic anion transporting polypeptide Organic cation transporter P-Glycoprotein Polypeptides Probenecid Propionates Proteins Quinolines - pharmacology Single photon emission computed tomography Tissue Distribution Tumors Vesicles
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