Targeting IL‐10, ZO‐1 gene expression and IL‐6/STAT‐3 trans‐signaling by a combination of atorvastatin and mesalazine to enhance anti‐inflammatory effects and attenuates progression of oxazolone‐induced colitis

Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa. The pathogenesis of UC is multifactorial, and the exact underlying mechanisms remain poorly understood. This study aims to investigate the effect of mesalazine and atorvas...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2021-02, Vol.35 (1), p.143-155
Hauptverfasser:	El‐Mahdy, Nageh Ahmed, El‐Sayad, Magda El‐Sayed, El‐Kadem, Aya Hassan, Abu‐Risha, Sally El‐Sayed
Format:	Artikel
Sprache:	eng
Schlagworte:	Atorvastatin Attenuation Bleeding Body weight Body weight loss Caspase Colon Diarrhea Gene expression Glutathione Histopathology IL‐10 IL‐6 Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 6 Mucosa Oxazolone Pathogenesis Peroxidase Pharmacology Rectum Signaling STAT‐3 Tissues Transcription Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis Weight loss ZO‐1
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