Evaluation of the DNA Alkylation Properties of a Chlorambucil‐Conjugated Cyclic Pyrrole‐Imidazole Polyamide

Hairpin pyrrole‐imidazole polyamides (hPIPs) and their chlorambucil (Chb) conjugates (hPIP‐Chbs) can alkylate DNA in a sequence‐specific manner, and have been studied as anticancer drugs. Here, we conjugated Chb to a cyclic PIP (cPIP), which is known to have a higher binding affinity than the corres...

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Veröffentlicht in:	Chemistry : a European journal 2021-02, Vol.27 (8), p.2782-2788
Hauptverfasser:	Hirose, Yuki, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Alkylates Alkylation Antitumor agents Binding sites Cancer Capillary electrophoresis Chemistry Chlorambucil Chlorambucil - chemistry Conjugates Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry DNA alkylator DNA recognition drug delivery Drugs Electrophoresis High-performance liquid chromatography Imidazole Imidazoles - chemistry Liquid chromatography Nucleotide sequence Nylons - chemistry Polyamide resins Polyamides Prostate cancer Pyrroles - chemistry Toxicity
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