Effects of Simulated Weightlessness on Metabolizing Enzymes and Pharmacokinetics of Folic Acid in SD Rats

Folic acid (FA) affect human physiology and drug metabolism. Up to now, the effect of microgravity on the pharmacokinetics of FA remains unclear. The pharmacokinetics of FA in Sprague–Dawley (SD) rats are laying a foundation for safe medicine administration of astronauts. Proteins expression of such...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/02/01, Vol.44(2), pp.162-168
Hauptverfasser:	Zhang, Yang, Zhao, Jun, Jing, Juan, Zhang, Ruitao, Zhou, Xuejiao, Gao, Jianyi, Wang, Jiaping, Li, Yongzhi, Liu, Xueying, Wang, Qingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-homocysteine S-methyltransferase Bioavailability Cystathionine b-synthase Drug metabolism Duodenum Enzymes Folic acid Gene expression Kidneys Life Sciences & Biomedicine Liquid chromatography Mass spectroscopy metabolic enzyme Metabolism Methionine Methylenetetrahydrofolate reductase Microgravity Oral administration Pharmacokinetics Pharmacology & Pharmacy Polymerase chain reaction Rodents Science & Technology simulated weightlessness tail-suspension model Weightlessness
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