Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

2-Oxoglutarate (2OG) is involved in biological processes including oxidations catalyzed by 2OG oxygenases for which it is a cosubstrate. Eukaryotic 2OG oxygenases have roles in collagen biosynthesis, lipid metabolism, DNA/RNA modification, transcriptional regulation, and the hypoxic response. Aspart...

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Veröffentlicht in:	Chemical science (Cambridge) 2020-12, Vol.12 (4), p.1327-1342
Hauptverfasser:	Brewitz, Lennart, Nakashima, Yu, Schofield, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biosynthesis Chemistry Crystallography Deoxyribonucleic acid Derivatives DNA Endoplasmic reticulum Growth factors Hydroxylation Hypoxia Lipid metabolism Lipids Mass spectrometry Natural products Nutrition Residues Substitutes Substrates
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