Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperatur...

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Veröffentlicht in:	RSC advances 2021-01, Vol.11 (1), p.23-29
Hauptverfasser:	Begum, Zubeda, Sannabe, Haruka, Seki, Chigusa, Okuyama, Yuko, Kwon, Eunsang, Uwai, Koji, Tokiwa, Michio, Tokiwa, Suguru, Takeshita, Mitsuhiro, Nakano, Hiroto
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Sprache:	eng
Schlagworte:	Adducts Alcohols Asymmetry Chemistry Enantiomers Esters
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container_title	RSC advances
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creator	Begum, Zubeda Sannabe, Haruka Seki, Chigusa Okuyama, Yuko Kwon, Eunsang Uwai, Koji Tokiwa, Michio Tokiwa, Suguru Takeshita, Mitsuhiro Nakano, Hiroto
description	Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature. Simple primary β-amino alcohols X act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters A with nitroalkenes B affording highly pure chiral Michael adducts C .
doi_str_mv	10.1039/d0ra09041g
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subjects	Adducts Alcohols Asymmetry Chemistry Enantiomers Esters
title	Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes
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