Systematic review of laboratory parameters predicting severity and fatality of COVID-19 hospitalised patients
Background: We reviewed studies that reported changes in laboratory parameters in COVID-19 hospitalised patients to identify those parameters that predict disease severity with a high degree of sensitivity to aid early clinical decision which is essential for timely triaging of patients. Methods: An...
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| Veröffentlicht in: | New Zealand journal of medical laboratory science 2020-11, Vol.74 (3), p.165-180 |
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| creator | Ikeagwulonu, Richard Chinaza Obeta, Mark Uchejeso Ugwu, Immaculata Ngozi |
| description | Background: We reviewed studies that reported changes in laboratory parameters in COVID-19 hospitalised patients to identify those parameters that predict disease severity with a high degree of sensitivity to aid early clinical decision which is essential for timely triaging of patients.
Methods: An electronic search of four databases comprising PubMed/Medline, Google Scholar, AJOL and JSTOR was performed to identify studies reporting changes in laboratory parameters in COVID-19 patients using key words "laboratory" OR "haematological" OR "cardiac" and "coronavirus 2019" OR ''COVID-19" OR "2019-nCoV" OR "SARS-CoV-2".
Results: A total of twenty-eight articles were reviewed out of 593 identified after duplicates removal. These 28 articles comprise 2,688 laboratory confirmed cases of COVID-19 patients comprising 1,418 male and 1,270 female patients with 32 different laboratory parameters identified. Comparing the mild to severe/critical cases our result showed a significant increase in lactate dehydrogenase (100%), D-dimer (100%), neutrophil to lymphocyte ratio (100%) as well as lymphocytopenia (96.0%), thrombocytopenia (83.3%), leukocytosis (71.4%) and neutrophilia (86.4%). Severe cases of COVID-19 had increased serum levels of myoglobin, cardiac troponin I, creatine kinase, creatine kinase-MB, N-terminal brain natriuretic peptide, urea, creatinine, cystatin C, platelet to lymphocyte ratio, international normalised ratio (NLR), platelet count, fibrin degradation products; and decreased levels of Hb, fibrinogen, uric acid, blood gases (PaO2 and PaCO2), and oxygenation index.
Conclusions: The observations in this study provide evidence of multiple organ involvement in COVID-19 disease. D-dimer, lactate dehydrogenase, lymphocytes, neutrophils, platelets, fibrinogen, NLR, oxygen index, and blood gases should be considered important in risk stratification to predict severe and fatal COVID-19 outcome in hospitalised patients. |
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Methods: An electronic search of four databases comprising PubMed/Medline, Google Scholar, AJOL and JSTOR was performed to identify studies reporting changes in laboratory parameters in COVID-19 patients using key words "laboratory" OR "haematological" OR "cardiac" and "coronavirus 2019" OR ''COVID-19" OR "2019-nCoV" OR "SARS-CoV-2".
Results: A total of twenty-eight articles were reviewed out of 593 identified after duplicates removal. These 28 articles comprise 2,688 laboratory confirmed cases of COVID-19 patients comprising 1,418 male and 1,270 female patients with 32 different laboratory parameters identified. Comparing the mild to severe/critical cases our result showed a significant increase in lactate dehydrogenase (100%), D-dimer (100%), neutrophil to lymphocyte ratio (100%) as well as lymphocytopenia (96.0%), thrombocytopenia (83.3%), leukocytosis (71.4%) and neutrophilia (86.4%). Severe cases of COVID-19 had increased serum levels of myoglobin, cardiac troponin I, creatine kinase, creatine kinase-MB, N-terminal brain natriuretic peptide, urea, creatinine, cystatin C, platelet to lymphocyte ratio, international normalised ratio (NLR), platelet count, fibrin degradation products; and decreased levels of Hb, fibrinogen, uric acid, blood gases (PaO2 and PaCO2), and oxygenation index.
Conclusions: The observations in this study provide evidence of multiple organ involvement in COVID-19 disease. D-dimer, lactate dehydrogenase, lymphocytes, neutrophils, platelets, fibrinogen, NLR, oxygen index, and blood gases should be considered important in risk stratification to predict severe and fatal COVID-19 outcome in hospitalised patients.</description><identifier>ISSN: 1171-0195</identifier><language>eng</language><publisher>Auckland: New Zealand Institute of Medical Laboratory Science</publisher><subject>Biochemical markers ; Blood ; Blood platelets ; Coronaviruses ; COVID-19 ; Creatine ; Creatine kinase ; Dehydrogenases ; Development and progression ; Diagnosis, Laboratory ; Disease transmission ; Epidemics ; Fibrin ; Health aspects ; Hematology ; Hospital patients ; Lymphocytes ; Medical laboratories ; Medical prognosis ; Medical research ; Mortality ; Myoglobin ; Natriuretic peptides ; Neutrophils ; Online searching ; Prevention ; Services for ; Severe acute respiratory syndrome coronavirus 2 ; Social aspects ; Troponin ; Uric acid</subject><ispartof>New Zealand journal of medical laboratory science, 2020-11, Vol.74 (3), p.165-180</ispartof><rights>COPYRIGHT 2020 New Zealand Institute of Medical Laboratory Science</rights><rights>Copyright New Zealand Institute of Medical Laboratory Science Nov 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Ikeagwulonu, Richard Chinaza</creatorcontrib><creatorcontrib>Obeta, Mark Uchejeso</creatorcontrib><creatorcontrib>Ugwu, Immaculata Ngozi</creatorcontrib><title>Systematic review of laboratory parameters predicting severity and fatality of COVID-19 hospitalised patients</title><title>New Zealand journal of medical laboratory science</title><description>Background: We reviewed studies that reported changes in laboratory parameters in COVID-19 hospitalised patients to identify those parameters that predict disease severity with a high degree of sensitivity to aid early clinical decision which is essential for timely triaging of patients.
Methods: An electronic search of four databases comprising PubMed/Medline, Google Scholar, AJOL and JSTOR was performed to identify studies reporting changes in laboratory parameters in COVID-19 patients using key words "laboratory" OR "haematological" OR "cardiac" and "coronavirus 2019" OR ''COVID-19" OR "2019-nCoV" OR "SARS-CoV-2".
Results: A total of twenty-eight articles were reviewed out of 593 identified after duplicates removal. These 28 articles comprise 2,688 laboratory confirmed cases of COVID-19 patients comprising 1,418 male and 1,270 female patients with 32 different laboratory parameters identified. Comparing the mild to severe/critical cases our result showed a significant increase in lactate dehydrogenase (100%), D-dimer (100%), neutrophil to lymphocyte ratio (100%) as well as lymphocytopenia (96.0%), thrombocytopenia (83.3%), leukocytosis (71.4%) and neutrophilia (86.4%). Severe cases of COVID-19 had increased serum levels of myoglobin, cardiac troponin I, creatine kinase, creatine kinase-MB, N-terminal brain natriuretic peptide, urea, creatinine, cystatin C, platelet to lymphocyte ratio, international normalised ratio (NLR), platelet count, fibrin degradation products; and decreased levels of Hb, fibrinogen, uric acid, blood gases (PaO2 and PaCO2), and oxygenation index.
Conclusions: The observations in this study provide evidence of multiple organ involvement in COVID-19 disease. D-dimer, lactate dehydrogenase, lymphocytes, neutrophils, platelets, fibrinogen, NLR, oxygen index, and blood gases should be considered important in risk stratification to predict severe and fatal COVID-19 outcome in hospitalised patients.</description><subject>Biochemical markers</subject><subject>Blood</subject><subject>Blood platelets</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Dehydrogenases</subject><subject>Development and progression</subject><subject>Diagnosis, Laboratory</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Fibrin</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hospital patients</subject><subject>Lymphocytes</subject><subject>Medical laboratories</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Mortality</subject><subject>Myoglobin</subject><subject>Natriuretic peptides</subject><subject>Neutrophils</subject><subject>Online searching</subject><subject>Prevention</subject><subject>Services for</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Social aspects</subject><subject>Troponin</subject><subject>Uric acid</subject><issn>1171-0195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkElLBDEQhfug4Lj8h4DnlmQ6S-co4woDHlzwFqrTlZkM3Z0xicr8e-MCIkgdiqr3vVdQe9WMMcVqyrQ4qA5T2lDKZSP0rBrvdynjCNlbEvHN4zsJjgzQhQg5xB3ZQoQRM8ZEthF7b7OfViThG0afdwSmnjjIMHwOxbm4e7q9qJkm65C2_nOfsC8h2eOU03G172BIePLTj6rHq8uHxU29vLu-XZwv6xVTUtZNDw3rOHKrtdK8mytsW3BcI0reSkap5tT2GpwtPHLeOc2UoA6pdND1zVF1-p27jeHlFVM2m_Aap3LSzHkrqBJK019qBQMaP7mQI9jRJ2vOJW-omGveFursH6pUj6O3YULny_6P4fnbEEefjQ3DgOVpYUobyMkkhGjXXzlfeogr0wdvoEuGUdM0TP6Kguq5UEpI2vIiNB8zmpAA</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Ikeagwulonu, Richard Chinaza</creator><creator>Obeta, Mark Uchejeso</creator><creator>Ugwu, Immaculata Ngozi</creator><general>New Zealand Institute of Medical Laboratory Science</general><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20201101</creationdate><title>Systematic review of laboratory parameters predicting severity and fatality of COVID-19 hospitalised patients</title><author>Ikeagwulonu, Richard Chinaza ; Obeta, Mark Uchejeso ; Ugwu, Immaculata Ngozi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1766-3da31b4e4c99794b27e88af49ee6486100940cd9afc176e44bf91750fe06fabd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemical markers</topic><topic>Blood</topic><topic>Blood platelets</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Dehydrogenases</topic><topic>Development and progression</topic><topic>Diagnosis, Laboratory</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Fibrin</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hospital patients</topic><topic>Lymphocytes</topic><topic>Medical laboratories</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Mortality</topic><topic>Myoglobin</topic><topic>Natriuretic peptides</topic><topic>Neutrophils</topic><topic>Online searching</topic><topic>Prevention</topic><topic>Services for</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Social aspects</topic><topic>Troponin</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeagwulonu, Richard Chinaza</creatorcontrib><creatorcontrib>Obeta, Mark Uchejeso</creatorcontrib><creatorcontrib>Ugwu, Immaculata Ngozi</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Australia & New Zealand Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>New Zealand journal of medical laboratory science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeagwulonu, Richard Chinaza</au><au>Obeta, Mark Uchejeso</au><au>Ugwu, Immaculata Ngozi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic review of laboratory parameters predicting severity and fatality of COVID-19 hospitalised patients</atitle><jtitle>New Zealand journal of medical laboratory science</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>74</volume><issue>3</issue><spage>165</spage><epage>180</epage><pages>165-180</pages><issn>1171-0195</issn><abstract>Background: We reviewed studies that reported changes in laboratory parameters in COVID-19 hospitalised patients to identify those parameters that predict disease severity with a high degree of sensitivity to aid early clinical decision which is essential for timely triaging of patients.
Methods: An electronic search of four databases comprising PubMed/Medline, Google Scholar, AJOL and JSTOR was performed to identify studies reporting changes in laboratory parameters in COVID-19 patients using key words "laboratory" OR "haematological" OR "cardiac" and "coronavirus 2019" OR ''COVID-19" OR "2019-nCoV" OR "SARS-CoV-2".
Results: A total of twenty-eight articles were reviewed out of 593 identified after duplicates removal. These 28 articles comprise 2,688 laboratory confirmed cases of COVID-19 patients comprising 1,418 male and 1,270 female patients with 32 different laboratory parameters identified. Comparing the mild to severe/critical cases our result showed a significant increase in lactate dehydrogenase (100%), D-dimer (100%), neutrophil to lymphocyte ratio (100%) as well as lymphocytopenia (96.0%), thrombocytopenia (83.3%), leukocytosis (71.4%) and neutrophilia (86.4%). Severe cases of COVID-19 had increased serum levels of myoglobin, cardiac troponin I, creatine kinase, creatine kinase-MB, N-terminal brain natriuretic peptide, urea, creatinine, cystatin C, platelet to lymphocyte ratio, international normalised ratio (NLR), platelet count, fibrin degradation products; and decreased levels of Hb, fibrinogen, uric acid, blood gases (PaO2 and PaCO2), and oxygenation index.
Conclusions: The observations in this study provide evidence of multiple organ involvement in COVID-19 disease. D-dimer, lactate dehydrogenase, lymphocytes, neutrophils, platelets, fibrinogen, NLR, oxygen index, and blood gases should be considered important in risk stratification to predict severe and fatal COVID-19 outcome in hospitalised patients.</abstract><cop>Auckland</cop><pub>New Zealand Institute of Medical Laboratory Science</pub><tpages>16</tpages></addata></record> |
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| subjects | Biochemical markers Blood Blood platelets Coronaviruses COVID-19 Creatine Creatine kinase Dehydrogenases Development and progression Diagnosis, Laboratory Disease transmission Epidemics Fibrin Health aspects Hematology Hospital patients Lymphocytes Medical laboratories Medical prognosis Medical research Mortality Myoglobin Natriuretic peptides Neutrophils Online searching Prevention Services for Severe acute respiratory syndrome coronavirus 2 Social aspects Troponin Uric acid |
| title | Systematic review of laboratory parameters predicting severity and fatality of COVID-19 hospitalised patients |
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