A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma
A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT)...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2021-01, Vol.57 (8), p.146-149 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Tan, Ping Zhuang, Weihua Li, Shufen Zhang, Jiapeng Xu, Hang Yang, Lu Liao, Yanbiao Chen, Mao Wei, Qiang |
| description | A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT) in human clear cell renal cell carcinoma (ccRCC) primary cells and tissues.
A lipid droplets (LDs) specific fluorescent probe TTIE is prepared for LDs specific image-guided photodynamic therapy (PDT), which can light up the LDs in human clear cell renal cell carcinoma cells and tissues, and kill tumor cells
via
PDT process. |
| doi_str_mv | 10.1039/d0cc07336a |
| format | Article |
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A lipid droplets (LDs) specific fluorescent probe TTIE is prepared for LDs specific image-guided photodynamic therapy (PDT), which can light up the LDs in human clear cell renal cell carcinoma cells and tissues, and kill tumor cells
via
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A lipid droplets (LDs) specific fluorescent probe TTIE is prepared for LDs specific image-guided photodynamic therapy (PDT), which can light up the LDs in human clear cell renal cell carcinoma cells and tissues, and kill tumor cells
via
PDT process.</description><subject>Fluorescent indicators</subject><subject>Kidney cancer</subject><subject>Light irradiation</subject><subject>Lipids</subject><subject>Photodynamic therapy</subject><subject>Synthesis</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>White light</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpd0clr3DAUB2AREpqlveSeIOglFNxK1n4cpksCgV5a6M3I8tOMgm05kg2d_z6aThaoDpJAnx5P-iF0SclnSpj50hHniGJM2iN0RpnkleD6z_F-L0ylGBen6DznB1IGFfodOmWMEyNqdYb-rnAfptDhLsWphxnPNm1ghg77fokJsoNxxlOKLWAfE96GzbYC74MLMLodDoPdQLVZQleuTNs4x2432iE4PG8h2WmHo8cJRttjB32ZbHJhjIN9j0687TN8eF4v0O_v336tb6v7nz_u1qv7yjGl54pKSRUhylAQrafKMAZAtNTec1szranTvlbK29oT0nIrJRfGgGdEQkspu0A3h7rlDY8L5LkZQt63YkeIS25qriStDVGy0I__0Ye4pNL6XmleC0WEKerTQbkUc07gmymVX0i7hpJmn0fzlazX__JYFXz9XHJpB-he6UsABVwdQMru9fQtUPYEhFGPeQ</recordid><startdate>20210125</startdate><enddate>20210125</enddate><creator>Tan, Ping</creator><creator>Zhuang, Weihua</creator><creator>Li, Shufen</creator><creator>Zhang, Jiapeng</creator><creator>Xu, Hang</creator><creator>Yang, Lu</creator><creator>Liao, Yanbiao</creator><creator>Chen, Mao</creator><creator>Wei, Qiang</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3750-3042</orcidid><orcidid>https://orcid.org/0000-0003-0492-7527</orcidid></search><sort><creationdate>20210125</creationdate><title>A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma</title><author>Tan, Ping ; Zhuang, Weihua ; Li, Shufen ; Zhang, Jiapeng ; Xu, Hang ; Yang, Lu ; Liao, Yanbiao ; Chen, Mao ; Wei, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-1661700791e5bf17933ee0868ff4a23881c8f277fa2f00b4a664599ef306eb113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Fluorescent indicators</topic><topic>Kidney cancer</topic><topic>Light irradiation</topic><topic>Lipids</topic><topic>Photodynamic therapy</topic><topic>Synthesis</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>White light</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Ping</creatorcontrib><creatorcontrib>Zhuang, Weihua</creatorcontrib><creatorcontrib>Li, Shufen</creatorcontrib><creatorcontrib>Zhang, Jiapeng</creatorcontrib><creatorcontrib>Xu, Hang</creatorcontrib><creatorcontrib>Yang, Lu</creatorcontrib><creatorcontrib>Liao, Yanbiao</creatorcontrib><creatorcontrib>Chen, Mao</creatorcontrib><creatorcontrib>Wei, Qiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Ping</au><au>Zhuang, Weihua</au><au>Li, Shufen</au><au>Zhang, Jiapeng</au><au>Xu, Hang</au><au>Yang, Lu</au><au>Liao, Yanbiao</au><au>Chen, Mao</au><au>Wei, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2021-01-25</date><risdate>2021</risdate><volume>57</volume><issue>8</issue><spage>146</spage><epage>149</epage><pages>146-149</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT) in human clear cell renal cell carcinoma (ccRCC) primary cells and tissues.
A lipid droplets (LDs) specific fluorescent probe TTIE is prepared for LDs specific image-guided photodynamic therapy (PDT), which can light up the LDs in human clear cell renal cell carcinoma cells and tissues, and kill tumor cells
via
PDT process.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33409527</pmid><doi>10.1039/d0cc07336a</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3750-3042</orcidid><orcidid>https://orcid.org/0000-0003-0492-7527</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2021-01, Vol.57 (8), p.146-149 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_journals_2484257059 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Fluorescent indicators Kidney cancer Light irradiation Lipids Photodynamic therapy Synthesis Toxicity Tumors White light |
| title | A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma |
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