Combined Structure and Ligand-Based Design of Selective Acetylcholinesterase Inhibitors

Acetylcholinesterase is a prime target for therapeutic intervention in Alzheimer’s disease. Acetylcholinesterase inhibitors (AChEIs) are used to improve cognitive abilities, playing therefore an important role in disease management. Drug repurposing screening has been performed on a corporate chemic...

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Veröffentlicht in:	Journal of chemical information and modeling 2021-01, Vol.61 (1), p.467-480
Hauptverfasser:	Pérez-Sánchez, Horacio, den Haan, Helena, Pérez-Garrido, Alfonso, Peña-García, Jorge, Chakraborty, Sandipan, Erdogan Orhan, Ilkay, Senol Deniz, Fatma Sezer, Villalgordo, José Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease FDA approval Hydrogen bonding Inhibitors Optimization Pharmaceutical Modeling Pharmacology Scaffolds Screening Selectivity Similarity Substructures Three dimensional models
Online-Zugang:	Volltext
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