Clinical implications of conventional cytogenetics, fuorescence in situ hybridization (FISH) and molecular testing in chronic myeloid leukaemia patients in the tyrosine kinase inhibitor era - A review

Despite the excellent treatment results obtained after the introduction of LKI drugs, especially Imatinib mesylate (IM), resistance to LKIs develops in approximately 35% - 40% of CML patients on LKI therapy. Since point mutations in BCR-ABL1 are a common cause of IM resistance, mutation analysis is...

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Veröffentlicht in:	Malaysian journal of pathology 2020-12, Vol.42 (3), p.307-321
Hauptverfasser:	Ankathil, Ravindran, Ismail, Siti Mariam, Yunus, Nazihah Mohd, Sulong, Sarina, Husin, Azlan, Abdullah, Abu Dzarr, Hassan, Rosline
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes Kinases Mutation Polymerase chain reaction
Online-Zugang:	Volltext
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