Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat‐induced spermatogenic damage via inhibiting the MAPK mediated oxidative stress and apoptosis in mice

Heat stress (HS) reaction is a stress response caused by adverse conditions. Currently, the incidence of reproductive malignancies particularly in males has been constantly increasing. This work investigated the effects of saponins derived from the stems and leaves of Panax ginseng (GSLS) on testicu...

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Veröffentlicht in:	Phytotherapy research 2021-01, Vol.35 (1), p.311-323
Hauptverfasser:	Liu, Wei, Leng, Jing, Hou, Jin‐gang, Jiang, Shuang, Wang, Zi, Liu, Zhi, Gong, Xiao‐jie, Chen, Chen, Wang, Ying‐ping, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Caspase Germ cells Giant cells Ginseng Glutathione Glutathione - metabolism Heat shock proteins Heat stress Heat tolerance Heat treatment Heat treatments Heme Heme Oxygenase-1 - metabolism Hot Temperature - adverse effects HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Hyperthermia Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Leaves Male Malondialdehyde Malondialdehyde - metabolism MAP kinase MAP Kinase Signaling System - drug effects MAPK Membrane Proteins - metabolism Mice Mice, Inbred ICR Oxidative stress Oxidative Stress - drug effects Oxygenase Panax - chemistry Panax ginseng Protein kinase Proteins Saponins Saponins - pharmacology Signal transduction Signaling Spermatogenesis - drug effects Stems Superoxide dismutase Superoxide Dismutase - metabolism Testes Testis - drug effects Testosterone Testosterone - blood the leaves of Panax ginseng Tubules
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