The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats
This study evaluated the potential of Punica granatum peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-02, Vol.28 (6), p.7134-7150 |
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| creator | El Bohi, Khlood M. Abdel-Motal, Sabry M. Khalil, Samah R. Abd-Elaal, Mayar Mahmoud Metwally, Mohamed M. M. ELhady, Walaa M. |
| description | This study evaluated the potential of
Punica granatum
peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks; orally), VM-treated group (443.6 mg/kg BW, every alternate day for 2 weeks; intraperitoneally), pre-treated group, and concomitant-treated group. The biochemical response and the histopathology of the hepatic and renal tissue of the treated animals were assessed. The results showed that VM treatment induced substantial hepatotoxicity and nephrotoxicity, evidenced by a significant elevation in tissue injury and lipid oxidative (malondialdehyde) and inflammatory response (C-reactive protein) biomarkers, with lowered antioxidants and protein levels. Additionally, VM treatment induced various morphological, cytotoxic, vascular, and inflammatory perturbations as well as upregulation in the immune-expression of Caspase-3 and downregulation of BCL-2. Moreover, PPEE co-treatment was found to reduce the VM-induced toxicity by protecting the tissue against reactive oxygen species (ROS)–mediated oxidative damage, and inflammation as well as hinder the apoptotic cell death by modulating the expression of apoptosis-related proteins. Thus, we conclude that the PPEE administration showed more restoring efficacy when administered prior to VM medication. |
| doi_str_mv | 10.1007/s11356-020-10999-3 |
| format | Article |
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Punica granatum
peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks; orally), VM-treated group (443.6 mg/kg BW, every alternate day for 2 weeks; intraperitoneally), pre-treated group, and concomitant-treated group. The biochemical response and the histopathology of the hepatic and renal tissue of the treated animals were assessed. The results showed that VM treatment induced substantial hepatotoxicity and nephrotoxicity, evidenced by a significant elevation in tissue injury and lipid oxidative (malondialdehyde) and inflammatory response (C-reactive protein) biomarkers, with lowered antioxidants and protein levels. Additionally, VM treatment induced various morphological, cytotoxic, vascular, and inflammatory perturbations as well as upregulation in the immune-expression of Caspase-3 and downregulation of BCL-2. Moreover, PPEE co-treatment was found to reduce the VM-induced toxicity by protecting the tissue against reactive oxygen species (ROS)–mediated oxidative damage, and inflammation as well as hinder the apoptotic cell death by modulating the expression of apoptosis-related proteins. Thus, we conclude that the PPEE administration showed more restoring efficacy when administered prior to VM medication.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-10999-3</identifier><identifier>PMID: 33029776</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Antibiotics ; Antioxidants ; Apoptosis ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bacterial infections ; Bcl-2 protein ; Biomarkers ; C-reactive protein ; Caspase-3 ; Cell death ; Chromatography ; Cytotoxicity ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Ethanol ; Free radicals ; Fruits ; Hepatotoxicity ; Histopathology ; Inflammation ; Inflammatory response ; Injuries ; Kidney ; Kidneys ; Lipids ; Liver ; Malondialdehyde ; Mass spectrometry ; Oxidative Stress ; Plant Extracts ; Pomegranate ; Proteins ; Punica granatum ; Rats ; Reactive oxygen species ; Research Article ; Scientific imaging ; Tissues ; Toxicity ; Vancomycin ; Veterinary medicine ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2021-02, Vol.28 (6), p.7134-7150</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-7990b1f24f1a5c8db5cec38fc29f47697229eed80440c2cfae56f66960eb87e3</citedby><cites>FETCH-LOGICAL-c412t-7990b1f24f1a5c8db5cec38fc29f47697229eed80440c2cfae56f66960eb87e3</cites><orcidid>0000-0002-5442-6870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-10999-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-10999-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33029776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Bohi, Khlood M.</creatorcontrib><creatorcontrib>Abdel-Motal, Sabry M.</creatorcontrib><creatorcontrib>Khalil, Samah R.</creatorcontrib><creatorcontrib>Abd-Elaal, Mayar Mahmoud</creatorcontrib><creatorcontrib>Metwally, Mohamed M. M.</creatorcontrib><creatorcontrib>ELhady, Walaa M.</creatorcontrib><title>The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>This study evaluated the potential of
Punica granatum
peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks; orally), VM-treated group (443.6 mg/kg BW, every alternate day for 2 weeks; intraperitoneally), pre-treated group, and concomitant-treated group. The biochemical response and the histopathology of the hepatic and renal tissue of the treated animals were assessed. The results showed that VM treatment induced substantial hepatotoxicity and nephrotoxicity, evidenced by a significant elevation in tissue injury and lipid oxidative (malondialdehyde) and inflammatory response (C-reactive protein) biomarkers, with lowered antioxidants and protein levels. Additionally, VM treatment induced various morphological, cytotoxic, vascular, and inflammatory perturbations as well as upregulation in the immune-expression of Caspase-3 and downregulation of BCL-2. Moreover, PPEE co-treatment was found to reduce the VM-induced toxicity by protecting the tissue against reactive oxygen species (ROS)–mediated oxidative damage, and inflammation as well as hinder the apoptotic cell death by modulating the expression of apoptosis-related proteins. Thus, we conclude that the PPEE administration showed more restoring efficacy when administered prior to VM medication.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bacterial infections</subject><subject>Bcl-2 protein</subject><subject>Biomarkers</subject><subject>C-reactive protein</subject><subject>Caspase-3</subject><subject>Cell death</subject><subject>Chromatography</subject><subject>Cytotoxicity</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Ethanol</subject><subject>Free radicals</subject><subject>Fruits</subject><subject>Hepatotoxicity</subject><subject>Histopathology</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Injuries</subject><subject>Kidney</subject><subject>Kidneys</subject><subject>Lipids</subject><subject>Liver</subject><subject>Malondialdehyde</subject><subject>Mass spectrometry</subject><subject>Oxidative Stress</subject><subject>Plant Extracts</subject><subject>Pomegranate</subject><subject>Proteins</subject><subject>Punica granatum</subject><subject>Rats</subject><subject>Reactive oxygen species</subject><subject>Research Article</subject><subject>Scientific imaging</subject><subject>Tissues</subject><subject>Toxicity</subject><subject>Vancomycin</subject><subject>Veterinary medicine</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u3CAURlHVqJkmfYEuKqRu2gUpfzZmWUVpGylSupg9YvBlwnSMp4Cj-EXyvCFxmu6yQohzz0Xfh9BHRs8YpepbZkw0LaGcEka11kS8QSvWMkmU1PotWlEtJWFCymP0PucdraTm6h06FoJyrVS7QvfrG8DgfXABopvx6PFhHGCbbLQF8JffUwzO4uU-DV_xAWCPodzYOO6Dw3BXknUFh4htKRAnW0Lc4lKttza6cZhdiKSksN1Cgh7vwy0kbGOP_4Q-woxLyHmCXAW7Kc2PnmRLPkVH3u4zfHg-T9D6x8X6_Be5uv55ef79ijjJeCFKa7phnkvPbOO6ftM4cKLzjmsvVasV5xqg76iU1HHnLTStb1vdUth0CsQJ-rxoD2n8W39RzG6cUqwbDZcdk4xp1lSKL5RLY84JvDmkMNg0G0bNYxNmacLUfM1TE0bUoU_P6mkzQP8y8i_6CogFyPUp1nT-735F-wAf8pdC</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>El Bohi, Khlood M.</creator><creator>Abdel-Motal, Sabry M.</creator><creator>Khalil, Samah R.</creator><creator>Abd-Elaal, Mayar Mahmoud</creator><creator>Metwally, Mohamed M. M.</creator><creator>ELhady, Walaa M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-5442-6870</orcidid></search><sort><creationdate>20210201</creationdate><title>The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats</title><author>El Bohi, Khlood M. ; Abdel-Motal, Sabry M. ; Khalil, Samah R. ; Abd-Elaal, Mayar Mahmoud ; Metwally, Mohamed M. 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M.</au><au>ELhady, Walaa M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>28</volume><issue>6</issue><spage>7134</spage><epage>7150</epage><pages>7134-7150</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>This study evaluated the potential of
Punica granatum
peel ethanol extract (PPEE) in attenuating the liver and kidney tissue injury induced by vancomycin (VM) treatment in rats. Fifty rats were distributed equally into five groups: control group, PPEE-administered group (100 mg/kg BW/day for 2 weeks; orally), VM-treated group (443.6 mg/kg BW, every alternate day for 2 weeks; intraperitoneally), pre-treated group, and concomitant-treated group. The biochemical response and the histopathology of the hepatic and renal tissue of the treated animals were assessed. The results showed that VM treatment induced substantial hepatotoxicity and nephrotoxicity, evidenced by a significant elevation in tissue injury and lipid oxidative (malondialdehyde) and inflammatory response (C-reactive protein) biomarkers, with lowered antioxidants and protein levels. Additionally, VM treatment induced various morphological, cytotoxic, vascular, and inflammatory perturbations as well as upregulation in the immune-expression of Caspase-3 and downregulation of BCL-2. Moreover, PPEE co-treatment was found to reduce the VM-induced toxicity by protecting the tissue against reactive oxygen species (ROS)–mediated oxidative damage, and inflammation as well as hinder the apoptotic cell death by modulating the expression of apoptosis-related proteins. Thus, we conclude that the PPEE administration showed more restoring efficacy when administered prior to VM medication.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33029776</pmid><doi>10.1007/s11356-020-10999-3</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-5442-6870</orcidid></addata></record> |
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| ispartof | Environmental science and pollution research international, 2021-02, Vol.28 (6), p.7134-7150 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antibiotics Antioxidants Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bacterial infections Bcl-2 protein Biomarkers C-reactive protein Caspase-3 Cell death Chromatography Cytotoxicity Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Ethanol Free radicals Fruits Hepatotoxicity Histopathology Inflammation Inflammatory response Injuries Kidney Kidneys Lipids Liver Malondialdehyde Mass spectrometry Oxidative Stress Plant Extracts Pomegranate Proteins Punica granatum Rats Reactive oxygen species Research Article Scientific imaging Tissues Toxicity Vancomycin Veterinary medicine Waste Water Technology Water Management Water Pollution Control |
| title | The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats |
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