Effect of vitamin D supplementation on pancreatic β-cell destruction and type 1 diabetes

[4] In vivo, vitamin D injection (20,000 IU/kg) improved hyperglycaemia and hypoinsulinemia in diabetic rats, as well as decreasing inflammation by inhibiting nuclear factor-kappa B (NF-κB) activity. The prevalence of T1D is increasing worldwide and currently, exogenous insulin injection is a major treatment for T1D patients with certain side effects, such as chronic macrovascular and microvascular complications. [...]developing a novel therapy to maintain endogenous insulin production would be beneficial in controlling glucose level and preventing complications of diabetes. [...]the effects of vitamin D on prevention or treatment of T1D remains controversial. [...]more long-time and large-scale studies are required to evaluate the role of vitamin D supplementation in T1D.