Natural podophyllotoxin analog 4DPG attenuates EMT and colorectal cancer progression via activation of checkpoint kinase 2

Epithelial–mesenchymal transition (EMT) is critical for the metastatic dissemination of cancer cells and contributes to drug resistance. In this study, we observed that epithelial colorectal cancer (CRC) cells transiently exposed to 5-fluorouracil (5-FU) (a chemotherapeutic drug for CRC) as well as...

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Veröffentlicht in:	Cell death discovery 2021-01, Vol.7 (1), p.25-25, Article 25
Hauptverfasser:	Katoch, Archana, Nayak, Debasis, Faheem, Mir Mohd, Kumar, Aviral, Sahu, Promod Kumar, Gupta, Ajai Prakash, Kumar, Lekha Dinesh, Goswami, Anindya
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil 631/67/1059/2326 692/699/67/322 Antiviral drugs Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis CHK2 protein Colorectal cancer Colorectal carcinoma Drug resistance E-cadherin Gelatinase A Immunoprecipitation Invasiveness Kinases Life Sciences Life Sciences & Biomedicine Localization Mesenchyme Metastases Metastasis p53 Protein Phosphorylation Podophyllotoxin Polyps Science & Technology siRNA Stem Cells Tissue inhibitor of metalloproteinase 1 Vimentin
Online-Zugang:	Volltext
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