Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats
Breast cancer is one of the leading causes of cancer deaths in women worldwide. Many women rely on plants as alternatives to prevent/treat cancer. Anthonotha macrophylla (Ceasalpiniaceae) is one of this ethnomedicinal plant used to cure cancer in Cameroon. This study was therefore undertaken to brin...
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| Veröffentlicht in: | Biológia 2021-02, Vol.76 (2), p.729-739 |
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| creator | Gueyo, Telesphore Nanbo Zingue, Stéphane Mvondo, Marie Alfrede Mmutlane, Edwin Ndinteh, Derek Tantoh Pieme, Constant Anatole Njamen, Dieudonné |
| description | Breast cancer is one of the leading causes of cancer deaths in women worldwide. Many women rely on plants as alternatives to prevent/treat cancer.
Anthonotha macrophylla
(Ceasalpiniaceae) is one of this ethnomedicinal plant used to cure cancer in Cameroon. This study was therefore undertaken to bring scientific evidence to this claim
.
The in vitro cytotoxicity of
A. macrophylla
aqueous extract was evaluated using resazurin reduction assay in five tumors and two non-tumor cell lines. Moreover, the chemopreventive potential of
A. macrophylla
aqueous extract was evaluated on 7,12 dimethylbenz[a]anthracene (DMBA) induced breast cancer in rats. The research focused on the incidence, burden, volume and histological analysis of breast tumors. In vitro,
A. macrophylla
extract exhibited cytotoxic effect in all tested cell lines with a CC
50
~ 279 and 132 μg/mL in human (MCF-7 and MDA-MB-231) and rodent breast cancer cells, respectively after 24 h. In vivo, the untreated DMBA-rats presented 100% of tumor incidence, while no tumor was detected in normal rats. Interestingly, a seven-month oral administration of
A. macrophylla
extract at the doses of 75 and 150 mg/kg BW resulted in a significant decrease of tumor incidence (
p
|
| doi_str_mv | 10.2478/s11756-020-00607-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2480787368</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2480787368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-28214cec6c7e0fc34de1ce18701364b9cbb693828b82ba4ae3e2b6c73fbe6a793</originalsourceid><addsrcrecordid>eNp9kc-KFDEQxoMoOK6-gKeAV7PmT0-SPq6Dq8KCHvQkEirparuXmaRN0sOOD-RzmnUUb54qVH7fV1V8hDwX_FJ2xr4qQpitZlxyxrnmhpkHZCOU0qzfavWQbHhrM8WtfUyelHLLeWe2XGzIz92pppru5kAhDjRADJhpmPCQloxHjHU-Il1SvX_BvtA00johvYp1SjHVCegBQk7LdNrvgX68pK8R1iOF7yumtVC8qxlCpSlS81JINswHrI31GH98ga_QbNo_RmRzHNaAA_UZodS_m8yRZqjlKXk0tun47E-9IJ-v33zavWM3H96-313dsKBEX5m0UnQBgw4G-RhUN6AIKKzhQunO98F73SsrrbfSQweoUPoGq9GjBtOrC_Li7Lvk1C4o1d2mNcc20snOcmON0rZR8ky1w0vJOLolzwfIJye4u8_DnfNwLQ_3Ow9nmkidRaXB8Rvmf9b_Uf0C-S2SAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2480787368</pqid></control><display><type>article</type><title>Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats</title><source>Springer Nature - Complete Springer Journals</source><creator>Gueyo, Telesphore Nanbo ; Zingue, Stéphane ; Mvondo, Marie Alfrede ; Mmutlane, Edwin ; Ndinteh, Derek Tantoh ; Pieme, Constant Anatole ; Njamen, Dieudonné</creator><creatorcontrib>Gueyo, Telesphore Nanbo ; Zingue, Stéphane ; Mvondo, Marie Alfrede ; Mmutlane, Edwin ; Ndinteh, Derek Tantoh ; Pieme, Constant Anatole ; Njamen, Dieudonné</creatorcontrib><description>Breast cancer is one of the leading causes of cancer deaths in women worldwide. Many women rely on plants as alternatives to prevent/treat cancer.
Anthonotha macrophylla
(Ceasalpiniaceae) is one of this ethnomedicinal plant used to cure cancer in Cameroon. This study was therefore undertaken to bring scientific evidence to this claim
.
The in vitro cytotoxicity of
A. macrophylla
aqueous extract was evaluated using resazurin reduction assay in five tumors and two non-tumor cell lines. Moreover, the chemopreventive potential of
A. macrophylla
aqueous extract was evaluated on 7,12 dimethylbenz[a]anthracene (DMBA) induced breast cancer in rats. The research focused on the incidence, burden, volume and histological analysis of breast tumors. In vitro,
A. macrophylla
extract exhibited cytotoxic effect in all tested cell lines with a CC
50
~ 279 and 132 μg/mL in human (MCF-7 and MDA-MB-231) and rodent breast cancer cells, respectively after 24 h. In vivo, the untreated DMBA-rats presented 100% of tumor incidence, while no tumor was detected in normal rats. Interestingly, a seven-month oral administration of
A. macrophylla
extract at the doses of 75 and 150 mg/kg BW resulted in a significant decrease of tumor incidence (
p
< 0.01 and
p
< 0.05), burden (70.01% and 53.28%) and volume (
p
< 0.001 and p < 0.01) compared to DMBA rats. The presence of polyphenols in the aqueous extract of
Anthonotha macrophylla
, as well as its antiradical properties, may account for its antitumor effects. These results therefore support the traditional use of
Anthonotha macrophylla
against breast cancer.</description><identifier>ISSN: 0006-3088</identifier><identifier>EISSN: 1336-9563</identifier><identifier>DOI: 10.2478/s11756-020-00607-7</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>9,10-Dimethyl-1,2-benzanthracene ; Anthracene ; Anticancer properties ; Antitumor activity ; Biocompatibility ; Biomedical and Life Sciences ; Biotechnology ; Breast cancer ; Cell Biology ; Cytotoxicity ; Life Sciences ; Microbiology ; Oral administration ; Original Article ; Plant Sciences ; Polyphenols ; Toxicity ; Tumor cell lines ; Tumors ; Zoology</subject><ispartof>Biológia, 2021-02, Vol.76 (2), p.729-739</ispartof><rights>Institute of Molecular Biology, Slovak Academy of Sciences 2020</rights><rights>Institute of Molecular Biology, Slovak Academy of Sciences 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-28214cec6c7e0fc34de1ce18701364b9cbb693828b82ba4ae3e2b6c73fbe6a793</citedby><cites>FETCH-LOGICAL-c319t-28214cec6c7e0fc34de1ce18701364b9cbb693828b82ba4ae3e2b6c73fbe6a793</cites><orcidid>0000-0002-4854-8783</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2478/s11756-020-00607-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2478/s11756-020-00607-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Gueyo, Telesphore Nanbo</creatorcontrib><creatorcontrib>Zingue, Stéphane</creatorcontrib><creatorcontrib>Mvondo, Marie Alfrede</creatorcontrib><creatorcontrib>Mmutlane, Edwin</creatorcontrib><creatorcontrib>Ndinteh, Derek Tantoh</creatorcontrib><creatorcontrib>Pieme, Constant Anatole</creatorcontrib><creatorcontrib>Njamen, Dieudonné</creatorcontrib><title>Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats</title><title>Biológia</title><addtitle>Biologia</addtitle><description>Breast cancer is one of the leading causes of cancer deaths in women worldwide. Many women rely on plants as alternatives to prevent/treat cancer.
Anthonotha macrophylla
(Ceasalpiniaceae) is one of this ethnomedicinal plant used to cure cancer in Cameroon. This study was therefore undertaken to bring scientific evidence to this claim
.
The in vitro cytotoxicity of
A. macrophylla
aqueous extract was evaluated using resazurin reduction assay in five tumors and two non-tumor cell lines. Moreover, the chemopreventive potential of
A. macrophylla
aqueous extract was evaluated on 7,12 dimethylbenz[a]anthracene (DMBA) induced breast cancer in rats. The research focused on the incidence, burden, volume and histological analysis of breast tumors. In vitro,
A. macrophylla
extract exhibited cytotoxic effect in all tested cell lines with a CC
50
~ 279 and 132 μg/mL in human (MCF-7 and MDA-MB-231) and rodent breast cancer cells, respectively after 24 h. In vivo, the untreated DMBA-rats presented 100% of tumor incidence, while no tumor was detected in normal rats. Interestingly, a seven-month oral administration of
A. macrophylla
extract at the doses of 75 and 150 mg/kg BW resulted in a significant decrease of tumor incidence (
p
< 0.01 and
p
< 0.05), burden (70.01% and 53.28%) and volume (
p
< 0.001 and p < 0.01) compared to DMBA rats. The presence of polyphenols in the aqueous extract of
Anthonotha macrophylla
, as well as its antiradical properties, may account for its antitumor effects. These results therefore support the traditional use of
Anthonotha macrophylla
against breast cancer.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Anthracene</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Breast cancer</subject><subject>Cell Biology</subject><subject>Cytotoxicity</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Oral administration</subject><subject>Original Article</subject><subject>Plant Sciences</subject><subject>Polyphenols</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Zoology</subject><issn>0006-3088</issn><issn>1336-9563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc-KFDEQxoMoOK6-gKeAV7PmT0-SPq6Dq8KCHvQkEirparuXmaRN0sOOD-RzmnUUb54qVH7fV1V8hDwX_FJ2xr4qQpitZlxyxrnmhpkHZCOU0qzfavWQbHhrM8WtfUyelHLLeWe2XGzIz92pppru5kAhDjRADJhpmPCQloxHjHU-Il1SvX_BvtA00johvYp1SjHVCegBQk7LdNrvgX68pK8R1iOF7yumtVC8qxlCpSlS81JINswHrI31GH98ga_QbNo_RmRzHNaAA_UZodS_m8yRZqjlKXk0tun47E-9IJ-v33zavWM3H96-313dsKBEX5m0UnQBgw4G-RhUN6AIKKzhQunO98F73SsrrbfSQweoUPoGq9GjBtOrC_Li7Lvk1C4o1d2mNcc20snOcmON0rZR8ky1w0vJOLolzwfIJye4u8_DnfNwLQ_3Ow9nmkidRaXB8Rvmf9b_Uf0C-S2SAQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Gueyo, Telesphore Nanbo</creator><creator>Zingue, Stéphane</creator><creator>Mvondo, Marie Alfrede</creator><creator>Mmutlane, Edwin</creator><creator>Ndinteh, Derek Tantoh</creator><creator>Pieme, Constant Anatole</creator><creator>Njamen, Dieudonné</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-4854-8783</orcidid></search><sort><creationdate>20210201</creationdate><title>Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats</title><author>Gueyo, Telesphore Nanbo ; Zingue, Stéphane ; Mvondo, Marie Alfrede ; Mmutlane, Edwin ; Ndinteh, Derek Tantoh ; Pieme, Constant Anatole ; Njamen, Dieudonné</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-28214cec6c7e0fc34de1ce18701364b9cbb693828b82ba4ae3e2b6c73fbe6a793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>Anthracene</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Biocompatibility</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Breast cancer</topic><topic>Cell Biology</topic><topic>Cytotoxicity</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Oral administration</topic><topic>Original Article</topic><topic>Plant Sciences</topic><topic>Polyphenols</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gueyo, Telesphore Nanbo</creatorcontrib><creatorcontrib>Zingue, Stéphane</creatorcontrib><creatorcontrib>Mvondo, Marie Alfrede</creatorcontrib><creatorcontrib>Mmutlane, Edwin</creatorcontrib><creatorcontrib>Ndinteh, Derek Tantoh</creatorcontrib><creatorcontrib>Pieme, Constant Anatole</creatorcontrib><creatorcontrib>Njamen, Dieudonné</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biológia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gueyo, Telesphore Nanbo</au><au>Zingue, Stéphane</au><au>Mvondo, Marie Alfrede</au><au>Mmutlane, Edwin</au><au>Ndinteh, Derek Tantoh</au><au>Pieme, Constant Anatole</au><au>Njamen, Dieudonné</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats</atitle><jtitle>Biológia</jtitle><stitle>Biologia</stitle><date>2021-02-01</date><risdate>2021</risdate><volume>76</volume><issue>2</issue><spage>729</spage><epage>739</epage><pages>729-739</pages><issn>0006-3088</issn><eissn>1336-9563</eissn><abstract>Breast cancer is one of the leading causes of cancer deaths in women worldwide. Many women rely on plants as alternatives to prevent/treat cancer.
Anthonotha macrophylla
(Ceasalpiniaceae) is one of this ethnomedicinal plant used to cure cancer in Cameroon. This study was therefore undertaken to bring scientific evidence to this claim
.
The in vitro cytotoxicity of
A. macrophylla
aqueous extract was evaluated using resazurin reduction assay in five tumors and two non-tumor cell lines. Moreover, the chemopreventive potential of
A. macrophylla
aqueous extract was evaluated on 7,12 dimethylbenz[a]anthracene (DMBA) induced breast cancer in rats. The research focused on the incidence, burden, volume and histological analysis of breast tumors. In vitro,
A. macrophylla
extract exhibited cytotoxic effect in all tested cell lines with a CC
50
~ 279 and 132 μg/mL in human (MCF-7 and MDA-MB-231) and rodent breast cancer cells, respectively after 24 h. In vivo, the untreated DMBA-rats presented 100% of tumor incidence, while no tumor was detected in normal rats. Interestingly, a seven-month oral administration of
A. macrophylla
extract at the doses of 75 and 150 mg/kg BW resulted in a significant decrease of tumor incidence (
p
< 0.01 and
p
< 0.05), burden (70.01% and 53.28%) and volume (
p
< 0.001 and p < 0.01) compared to DMBA rats. The presence of polyphenols in the aqueous extract of
Anthonotha macrophylla
, as well as its antiradical properties, may account for its antitumor effects. These results therefore support the traditional use of
Anthonotha macrophylla
against breast cancer.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.2478/s11756-020-00607-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4854-8783</orcidid></addata></record> |
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| subjects | 9,10-Dimethyl-1,2-benzanthracene Anthracene Anticancer properties Antitumor activity Biocompatibility Biomedical and Life Sciences Biotechnology Breast cancer Cell Biology Cytotoxicity Life Sciences Microbiology Oral administration Original Article Plant Sciences Polyphenols Toxicity Tumor cell lines Tumors Zoology |
| title | Cytotoxic and cancer chemopreventive potentials of the Anthonotha macrophylla P. Beauv aqueous extract on 7,12-dimethylbenz[a]anthracene-induced breast cancer in rats |
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