Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine

Tumour-associated macrophages have been implicated in pancreatic ductal adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by macrophages might have a role in this process. Here, we demonstrated that large EVs released by anti-inflammatory human macrophages decreased PDAC c...

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Veröffentlicht in:	Cancer letters 2021-03, Vol.501, p.210-223
Hauptverfasser:	Xavier, Cristina P.R., Castro, Inês, Caires, Hugo R., Ferreira, Dylan, Cavadas, Bruno, Pereira, Luisa, Santos, Lúcio L., Oliveira, Maria J., Vasconcelos, M. Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Anti-inflammatory macrophages Antibodies Biomarkers Brownian motion Cancer therapies Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - mortality Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy CHI3L1 Chitinase Chitinase-3-Like Protein 1 - genetics Chitinase-3-Like Protein 1 - metabolism Cytokines Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug resistance Drug Resistance, Neoplasm - drug effects Extracellular signal-regulated kinase Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Fibronectin Fibronectins - genetics Fibronectins - metabolism FN1 Gemcitabine Gemcitabine resistance Gene expression Gene Expression Regulation, Neoplastic - drug effects Genomes Humans Inflammation Macrophages Macrophages - metabolism Medical prognosis Metastases Microscopy Nanoparticles Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Patients PDAC Pentoxifylline - pharmacology Proteins Proteomics Pyridones - pharmacology Stroma Survival Analysis Tumors Up-Regulation - drug effects
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